Repozytorium publikacji - Politechnika Gdańska

Aim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated with inflammatory response and hyaluronate degradation showed increased DNA methylation before the transition, while those involved in embryonic morphogenesis, neuron differentiation and synapse functions did so after. A number of the methylome alterations were retained until adulthood and correlated with gene expression, while the functional associations imply that scarless healing depends on epigenetic regulation.

Autorzy

• dr inż. Justyna Podolak-Popinigis link otwiera się w nowej karcie ,
• Anna Ronowicz,
• Monika Dmochowska link otwiera się w nowej karcie ,
• Agnieszka Jakubiak link otwiera się w nowej karcie ,
• prof. dr hab. inż. Paweł Sachadyn link otwiera się w nowej karcie