Repozytorium publikacji - Politechnika Gdańska

The crystal structure of a nitrilotriacetate (nta) oxidovanadi-um(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]+, of [4-Me(Py)H][VO(nta)(H2O)] stoichiometry was determined. The com-plex comprises a discrete mononuclear [VO(nta)(H2O)]–coordinationentity that can be rarely found among other known compounds con-taining nitrilotriacetate oxidovanadium(IV) moieties. The complex wascharacterized by spectroscopic (IR and EPR) methods, magnetic mea-surements, and thermogravimetry (TG-FTIR). The stability of the titlecompound in aqueous solutions was investigated by using the potentio-metric titration method. Furthermore, spectrophotometric (UV/Vis)studies have revealed that the compound is capable to scavenge the superoxide free radicals (O2•–) as well as stable organic radicals i.e.2,2⬘-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical(ABTS+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•). Finally,biological properties of the complex studied were investigated in rela-tion to its cytoprotective activity against the oxidative damage gener-ated exogenously by using hydrogen peroxide in the HT22 hippocam-pal neuronal cell line (the MTT assay). Additionally, the biologicalaction of the compound towards two human osteosarcoma HOS andMG-63 cell lines (the MTT and BrdU tests) as well as the untrans-formed human osteoblast hFOB 1.19 cell line was tested.

Autorzy

• Aleksandra Tesmar link otwiera się w nowej karcie ,
• Dariusz Wyrzykowski,
• dr hab. Katarzyna Kazimierczuk link otwiera się w nowej karcie ,
• Julia Kłak,
• Kowalski Szymon,
• Iwona Inkielewicz-Stępniak,
• Joanna Drzeżdżon,
• Dagmara Jacewicz,
• Lech Chmurzyński