Repozytorium publikacji - Politechnika Gdańska

Aims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the differentially methylated regions were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several differentially methylated regions overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest a potential epigenetic determinants of regenerative phenomenon

Autorzy

• dr inż. Bartosz Górnikiewicz link otwiera się w nowej karcie ,
• Anna Ronowicz,
• Piotr Madanecki,
• prof. dr hab. inż. Paweł Sachadyn link otwiera się w nowej karcie