Repozytorium publikacji - Politechnika Gdańska

New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50.

Autorzy

• Michał Prejs link otwiera się w nowej karcie ,
• dr hab. inż. Grzegorz Cholewiński link otwiera się w nowej karcie ,
• Piotr Trzonkowski,
• prof. dr hab. inż. Agata Kot-Wasik link otwiera się w nowej karcie ,
• prof. dr hab. inż. Krystyna Dzierzbicka link otwiera się w nowej karcie