Repozytorium publikacji - Politechnika Gdańska

To understand the therapeutic application of polyphenols extracted from Kaffir (PolKaf) and Key (PolKey) limesdifferent analytical methods were applied. Based on quantitative analysis by two dimensional gas chromato-graphy (GC×GC) and time of flight mass spectrometry (TOFMS) it can be observed that the biggest differencesin the contents of selected terpenes of Kaffir and Key limes occur in chemical compounds such as limonene, citraland terpinen-4-ol. Limonene concentration is almost 5 times higher in the volatile fraction of Key lime than inKaffir lime. In the case of citral, the difference in concentration of this compound in Kaffir is 20 µg/g lower thanin Key lime. Higher concentration of terpinen-4-ol was noted in Kaffir lime samples and the content was almost23 times higher. Terpinen-4-ol is the major chemical compound of volatile fraction of Kaffir lime. Among thedetermined terpenes, potential markers of aroma were selected: terpinen-4-ol and citral for characterization ofKaffir and Key limes. Antioxidant assays revealed the highest bioactivity of Kaffir lime. Fluorescence studiesbetween the interaction of polyphenols with human serum albumin (HSA) showed relatively high bindingabilities in comparison with some antiplatelet drugs. The docking results showed that the hydrophobic residuesare responsible for the interaction with the phyto-constituents. Citral is the best scored ADMET descriptor. Theantioxidant strong affinity to HSA and synergism in bioactivity are the main indices in health application ofcitrus fruits.

Autorzy

• dr Rajamohamed Beema Shafreen,
• Martyna Lubinska-Szczygeł link otwiera się w nowej karcie ,
• Anna Różańska link otwiera się w nowej karcie ,
• dr inż. Tomasz Dymerski link otwiera się w nowej karcie ,
• prof. dr hab. inż. Jacek Namieśnik link otwiera się w nowej karcie ,
• Elena Katrich,
• Shela Gorinstein