Repozytorium publikacji - Politechnika Gdańska

Two dimeric compounds of the general formulae (Et3NH)2[Rh2(μ2-L)4Cl2] (1) (where L = thiophene-2-carboxylate) and [((η6-p-cymene)Ru)2(μ-Cl)3]PF6 (2) have been synthesized using a new method. The unique anionic complex 1 (space group P bca) has octahedral coordination in which the equatorial positions are occupied by the oxygen atoms of four thiophene-2-carboxylates in a paddle wheel fashion. In complex 2 (space group ), each Ru(II) ion exhibits a pseudo-octahedral, three-legged piano-stool geometry. The electronic structure and absorption spectral features of 1 were also investigated by means of absorption spectroscopy (UV–Vis) and TD-DFT calculations. The biological studies of 1 and 2, such as cytotoxicity, lipophilicity and interactions with DNA and BSA, point on structure-cytotoxic activity relationship of obtained dimers. The results obtained via MTT, SRB assays, UV–Vis and CD spectroscopy, suggest that the rhodium dimer interacts with DNA via groove binding, whereas 2 binds to DNA via electrostatic interactions only. The effect of the dimeric complexes on the cytotoxicity of three human cancer lines, myelomonocytic leukaemia (MV-4-11), colon adenocarcinoma (LoVo) and breast adenocarcinoma (MCF-7), as well as on normal mice fibroblast cells (BALB/3T3), has been screened. Cisplatin was used as a reference drug. As a general observation, the properties reported in this paper suggest that the rhodium complex has considerable potential as an anticancer agent against myelomonocytic leukaemia (IC50 = 4.02 µM).

Autorzy

• dr Joanna Masternak,
• Agnieszka Gilewska,
• dr hab. Katarzyna Kazimierczuk link otwiera się w nowej karcie ,
• Oleksiy Khavryuchenko,
• Joanna Wietrzyk,
• Trynda Justyna,
• dr hab. Barbara Barszcz