Repozytorium publikacji - Politechnika Gdańska

Ruthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations were done. Their antimicrobial activity (MIC, MBC/MFC) was examinedinvitroagainstStaphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecalis,Pseudomonasaeruginosa,Proteus vulgarisandCandida albicans. Their cytotoxic effects, using the MTT assay, againstthree cancer cell lines: HL-60, NALM-6, WM-115 and normal human foreskinfibroblasts (HFF-1) werealso investigated. The influence of the new arene–ruthenium(II) complexes on the DNA structure wasalso tested. From our results, compound2dshowed higher cytotoxicity against melanoma cell line WM-115 than cisplatin. Strong biostatic and biocidal activity of the tested complexes against Gram-positivebacteria, includingS. aureus,S. epidermidisandE. faecaliswas demonstrated. The new arene–ruthenium(II) compounds could not only inhibit proliferation of cancer cells, but also protect patientsagainst malignant wound infections.

Autorzy

• Ewelina Namiecińska,
• Beata Sadowska,
• Marzena Więckowska-Szakiel,
• prof. dr hab. inż. Anna Dołęga link otwiera się w nowej karcie ,
• Beata Pasternak,
• Magdalena Grazul,
• Elzbieta Budzisz