Repozytorium publikacji - Politechnika Gdańska

Background: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation(HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years). Results: We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema. Conclusions: Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.

Autorzy

• Agnieszka Gruszecka,
• Monika Waskow,
• Marta A. Malkiewicz,
• J Neary,
• Jyotpal Singh,
• Taylor Teckchandani,
• Gregory Kratzig,
• Magdalena Wszedybyl-Winklewska,
• Andrzej F. Frydrychowski,
• prof. dr hab. inż. Jacek Rumiński link otwiera się w nowej karcie ,
• mgr inż. Natalia Głowacka link otwiera się w nowej karcie ,
• Piotr Lass,
• Pawel Winklewski,
• dr hab. Marcin Gruszecki link otwiera się w nowej karcie