Repozytorium publikacji - Politechnika Gdańska

Biodegradable porous scaffolds with oriented interconnected pores and high mechanical are load-bearing biomaterials for bone tissue engineering. Herein, we report a simple, non-toxic, and cost-effective method to fabricate high-strength porous biodegradable scaffolds, composed of a polymer matrix of polycaprolactone (PCL) and water-soluble poly (ethylene oxide) (PEO) as a sacrificial material by integrating annealing treatment, pressure-induced flow (PIF) processing and particulate leaching techniques. The microstructure, crystal orientation, and crystallization behavior were studied by scanning electron microscope (SEM), 2D X-ray techniques, and differential scanning calorimetry (DSC). Through the analysis of SEM and 2D X-ray results, the proposed hybrid strategy aided formation of porous PCL scaffolds with highly oriented pore structures as well as suitable pore size and pore connectivity. Owing to the improvement of crystal orientation and crystallinity after PIF processing, the obtained scaffolds exhibited higher tensile strength (14.1 MPa), compressive strength (6.6 MPa), bending strength (5.9 MPa), and elongation at break (above 150%) compared with the non-oriented porous scaffolds. In addition, NIH-3T3 fibroblast cell culture unveiled in vitro biocompatibility of the scaffolds. Overall, the obtained oriented porous PCL scaffolds exhibited good biocompatibility, elongated cell morphology, and highly strengthened oriented structure for load-bearing bone tissue applications.

Autorzy

• Tairong Kuang,
• Shaowei Chen,
• Zhipeng Gu,
• Zhisen Shen,
• dr inż. Aleksander Hejna link otwiera się w nowej karcie ,
• dr inż. Mohammad Saeb link otwiera się w nowej karcie ,
• Feng Chen,
• Mingqiang Zhong,
• Tong Liu