Repozytorium publikacji - Politechnika Gdańska

Glucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating microbial cell membranes, has been improved using the pro-drug approach. On the other hand, a number of heterocyclic and polycyclic compounds demonstrating antimicrobial activity have been presented as putative inhibitors of the enzyme, based on the results of molecular docking to GlcN-6-P synthase matrix. The most active compounds of this group could be considered promising leads for development of novel antimicrobial drugs or antidiabetics, provided their selective toxicity is confirmed.

Autorzy

• Joanna Stefaniak link otwiera się w nowej karcie ,
• Michał Nowak link otwiera się w nowej karcie ,
• dr hab. inż. Marek Wojciechowski link otwiera się w nowej karcie ,
• prof. dr hab. inż. Sławomir Milewski link otwiera się w nowej karcie ,
• dr inż. Andrzej Skwarecki link otwiera się w nowej karcie