Repozytorium publikacji - Politechnika Gdańska

Introduction Data regarding patients with a previous medical record of immunosuppression treatment who have undergone transcatheter aortic valve implantation (TAVI) are limited and extremely inconclusive. Available studies are mostly short term observations; thus there is a lack of evidence on efficacy and safety of TAVI in this specific group of patients. Aim To compare the in-hospital and long-term outcomes between patients with or without a medical history of immunosuppressive treatment undergoing TAVI for aortic valve stenosis (AS). Material and methods We conducted a retrospective registry-based analysis including patients undergoing TAVI for AS at 5 centres between January 2009 and August 2017. The primary endpoint was long-term all-cause mortality. Secondary endpoints comprised major vascular complications, life-threatening or disabling bleeding, stroke and new pacemaker implantation. Results Of 1451 consecutive patients who underwent TAVI, two propensity-matched groups including 25 patients with a history of immunosuppression and 75 patients without it were analysed. No differences between groups in all-cause mortality were found in a median follow-up time of 2.7 years following TAVI (p = 0.465; HR = 0.73; 95% CI: 0.30–1.77). The rate of major vascular complications (4.0% vs. 5.3%) was similar in the two groups (p = 1.000). There were no statistically significant differences in the composite endpoint combining life-threatening or disabling bleeding, major vascular complications, stroke and new pacemaker implantation (40.0% vs. 20.0%, p = 0.218). Conclusions Patients who had undergone TAVI for AS had similar long-term mortality regardless of whether they had a previous medical record of immunosuppression. Procedural complication rates were comparable between the groups.

Autorzy

• Michał Walczewski,
• Aleksandra Gąsecka,
• Adam Witkowski,
• Maciej Dabrowski,
• Zenon Huczek,
• Radosław Wilimski,
• Andrzej Ochała,
• Radosław Parma,
• Bartosz Rymuza,
• Marek Grygier,
• Marek Jemielity,
• Anna Olasińska-Wiśniewska,
• Dariusz Jagielak,
• Radosław Targoński,
• mgr inż. Krzysztof Pastuszak link otwiera się w nowej karcie ,
• dr Peter Gresner,
• Marcin Grabowski,
• Janusz Kochman