Repozytorium publikacji - Politechnika Gdańska

In this paper, we present the synthesis of four new complexes: the dimeric precursor [Ir(dmppz)2(μ-Cl)]2 (1) (Hdmppz – 3,5-dimethyl-1-phenyl-1H-pyrazole) and heteroleptic bis-cyclometalated complexes: [Ir (dmppz)2 (Py2CO)]PF6 · 1 2 CH2 Cl2 (2), [Ir(dmppz)2 (H2biim)]PF6·H 2 O (3), and [Ir(dmppz)2 (PyBIm)]PF 6 (4), with auxiliary N,N-donor ligands: 2-di(pyridyl)ketone (Py2CO), 2,2’-biimidazole (H 2biim) and 2-(2’-pyridyl)ben- zimidazole (PyBIm). In the obtained complexes, SC-X-ray analysis revealed that Ir( III) has an octahedral coordination sphere with chromophores of the type {IrN2 C2Cl2 } (1) or {IrN 4C 2} (2–4). The complexes obtained, which have been fully characterised by physicochemical methods (CHN, TG, FTIR, UV-Vis, PL and 1 H, 13 C, 15 N NMR), were used to continue our studies on the factors influencing the cytotoxic pro- perties of potential chemotherapeutic agents (in vitro). To this end, the following studies are presented: (i) comparative analysis of the effects on the biological properties of N,N-donor ligands and C,N-donor ligands in the studied complexes, (ii) studies of the interactions of the compounds with the selected molecular target: DNA and BSA (UV-Vis, CD and PL methods), (iii) and the reactivity towards redox mole- cules: GSH, NADH (UV-Vis and/or ESI-MS methods), (iv) cytotoxic activity (IC50) of potential chemothera- peutics against MCF-7, K-562 and CCRF-CEM cell lines.

Autorzy

• dr hab. Joanna Masternak,
• Karol Okła,
• Adam Kubas,
• Jiří Voller,
• Karolína Kozlanská,
• mgr Małgorzata Zienkiewicz-Machnik,
• Agnieszka Gilewska,
• Jerzy Sitkowski,
• Anna Kamecka,
• dr hab. Katarzyna Kazimierczuk link otwiera się w nowej karcie ,
• dr hab. Barbara Barszcz