Repozytorium publikacji - Politechnika Gdańska

Perfluorooctanoic acid (PFOA) has been widely documented to affect various aspects of health, including development, metabolism and neuronal function in a variety of organisms. Despite numerous reports detailing these effects, a comprehensive mechanistic model remains elusive, especially with regard to the long-term effects of PFOA, as it bioaccumulates in food chains with a long half-life. In this study, we evaluated the impact of PFOA on several critical physiological states of Drosophila melanogaster. Our findings indicate that PFOA exposure significantly decreases reproductive capacity and induces alterations in starvation resistance and feeding behavior in flies. Interestingly, PFOA exposure also caused changes in locomotor activity and sleep patterns compared with flies receiving a standard diet. Notably, compared with controls, the F2 generation showed increased locomotion and shorter sleep duration during the dark phase, even without direct exposure to PFOA, indicating possible transgenerational effects.

Autorzy

• Sifang Liao,
• Chengxi Sun,
• Francisco Alejandro Lagunas-Rangel,
• Wen Liu,
• Shiyao Yi,
• Dalia Browne-Johnson,
• Filippa Eklund,
• Ying Zhang,
• dr hab. inż. Błażej Kudłak link otwiera się w nowej karcie ,
• Michael Williams,
• Helgi B. Schiöth