Repozytorium publikacji - Politechnika Gdańska

Objective: Cognitive deficits are one of the most debilitating comorbidities in epilepsy and other neurodegenerative, neuropsychiatric, and neurodevelopmental brain disorders. Current diagnostic and therapeutic options are limited and lack objective measures of the underlying neural activities. In this study, electrophysiological biomarkers that reflect cognitive functions in clinically validated batteries were determined to aid diagnosis and treatment in specific brain regions. Methods: We employed a CANTAB battery of neuropsychological tasks probing memory and executive functions in 86 epilepsy patients undergoing clinical EEG monitoring. EEG electrode signals during performance of particular battery tasks were decomposed to identify specific frequency bands and cortical areas that differentiated patients with impaired, normal, and good standardized performance according to their age and gender. Results: The anterior prefrontal cortical EEG power in the theta frequency band was consistently lower in patients with impaired memory and executive function performance (z-score < -1). This effect was evident in all four behavioral measures of executive, visual, spatial, and working memory functions and was confined to the cortical area of all four frontal pole electrodes (Nz, Fpz, Fp1, Fp2). Significance: Theta EEG power in the anterior prefrontal cortex provides simple, accessible, and objective electrophysiological measure of memory and executive functions in epilepsy. Our results suggest a feasible clinical biomarker for diagnosis, monitoring, and treatment of cognitive deficits with emerging targeted neuromodulation approaches.

Autorzy

• Nastaran Hamedisheihani link otwiera się w nowej karcie ,
• dr Jesus Garcia Salinas link otwiera się w nowej karcie ,
• PhD Brent Berry,
• PhD Gregory Worrell,
• dr Michał Kucewicz link otwiera się w nowej karcie