Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, as isosteres of purine, are of interest for pharmaceutical research as potential substrates for the synthesis of cGMP-PDE5 inhibitors. We present a novel, alternative method for the synthesis of imidazotriazinones, that differs from the previously reported ones with respect to the method of construction of the triazinone ring in the molecule. The key step in our approach is condensation of an appropriate a-keto-ester with amidrazones, leading to the triazinone heterocycle. Several different substituted imidazolo-triazinones have been synthesized in this manner.
Authors
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.tet.2012.11.037
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2013