Repozytorium publikacji - Politechnika Gdańska

Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones, as isosteres of purine, are of interest for pharmaceutical research as potential substrates for the synthesis of cGMP-PDE5 inhibitors. We present a novel, alternative method for the synthesis of imidazotriazinones, that differs from the previously reported ones with respect to the method of construction of the triazinone ring in the molecule. The key step in our approach is condensation of an appropriate a-keto-ester with amidrazones, leading to the triazinone heterocycle. Several different substituted imidazolo-triazinones have been synthesized in this manner.

Autorzy

• dr hab. inż. Teresa Olszewska link otwiera się w nowej karcie ,
• Ewa Gajewska link otwiera się w nowej karcie ,
• prof. dr hab. inż. Maria Jolanta Milewska link otwiera się w nowej karcie