Amino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate or L-glutamine to the keto forms of sugar phosphates or sugar nucleotides. The synthetic introduction of amin o functionalities in a regio- and stereoselective manner onto sugar scaffolds represents a substantial challenge. Most of the modern methods of for the preparation of 1-, 2- and 3-amino sugars are those starting from “an active ester” of carbohydrate derivatives, glycals, alcohols, carbonyl compounds and amino acids . A substantial progress in the development of region- and stereoselective methods of amino sugar synthesis has been made in the recent years, due to the application of meta l-based catalysts and tethered approaches. A comprehensive review on the current state of knowledge on biosynthes is and chemical synthesis of amino sugars is presented.
Authors
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.carres.2016.08.005
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2016
