Nystatin A1, a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight into the course and mechanism of the transformation and its effect on the conformation of the subject molecule.
Authors
- dr inż. Katarzyna Szwarc-Karabyka link open in new tab ,
- Marcin Płosiński link open in new tab ,
- Karolina Czerniejewska link open in new tab ,
- dr hab. inż. Tomasz Laskowski link open in new tab ,
- Arkadiusz Leniak link open in new tab ,
- prof. dr hab. inż. Jacek Czub link open in new tab ,
- dr inż. Paweł Kubica link open in new tab ,
- dr inż. Paweł Sowiński link open in new tab ,
- dr hab. inż. Jan Pawlak link open in new tab ,
- prof. dr hab. inż. Edward Borowski link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1002/mrc.4478
- Category
- Publikacja w czasopiśmie
- Type
- artykuł w czasopiśmie wyróżnionym w JCR
- Language
- angielski
- Publication year
- 2016
