The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3,I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one,C22H16O3,II, are reported. These compounds are of interest with respect to biological activity. Both structures display intermolecular C—H---O and O—H---O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by pi–pi interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C---H interaction in the Hirshfeld surface.
Authors
- Kamil Suchojad,
- prof. dr hab. inż. Anna Dołęga link open in new tab ,
- Angelika Adamus-Grabicka,
- Elżbieta Budzisz link open in new tab ,
- Magdalena Małecka
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1107/s2056989019015639
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2019
