In this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the development of novel, non-toxic, and endowed with an analgesic activity anticancer drugs. More preclinical and clinical studies are needed to explore these opportunities.
Authors
- mgr Justyna Budka,
- mgr inż. Szymon Kowalski,
- mgr Monika Chylińska,
- prof. dr hab. inż. Krystyna Dzierzbicka link open in new tab ,
- Iwona Inkielewicz-Stępniak
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.2174/0929867327666200304122406
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2021
