A new simple method for the synthesis of 2-ethynylphenyl(diaryl)phosphine oxides via ring opening of benzophosphol-3-yl triflates has been developed. This process occurs via nucleophilic attack of a Grignard reagent at the phosphorus center, which results in ring opening and cleavage of a leaving group. The reaction proceeds under mild conditions and, within 15−60 min, leads to a library of previously unavailable 2-ethynylphenylphosphine oxides in yields up to 98%.
Authors
- dr hab. inż. Łukasz Ponikiewski link open in new tab ,
- dr Sylwia Sowa
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1021/acs.joc.1c01629
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2021
