Conjugates composed of C2-18 fatty acid (FA) residues as a molecular carrier and 5-fluorocytosine (5-FC) as an active agent, released upon the action of intracellular esterases on the ester bond between FA and “trimethyl lock” intramolecular linker, demonstrate good in vitro activity against human pathogenic yeasts of Candida spp. The minimal inhibitory concentrations (MIC) values for the most active conjugates containing caprylic (C8), capric (C10), lauric (C12), or myristic (C14) acid residues were in the 2–64 μg mL.
Authors
- Michał Nowak link open in new tab ,
- dr inż. Andrzej Skwarecki link open in new tab ,
- dr inż. Joanna Pilch link open in new tab ,
- Justyna Górska link open in new tab ,
- dr hab. inż. Piotr Szweda link open in new tab ,
- prof. dr hab. inż. Maria Milewska link open in new tab ,
- prof. dr hab. inż. Sławomir Milewski link open in new tab
Additional information
- DOI
- Digital Object Identifier link open in new tab 10.1016/j.ejmech.2023.115293
- Category
- Publikacja w czasopiśmie
- Type
- artykuły w czasopismach
- Language
- angielski
- Publication year
- 2023
