2021 - Repozytorium publikacji - Politechnika Gdańska

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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
- Jarosław Mazuryk
- Izabela Puchalska
- Kamil Koziński
- Magdalena J. Ślusarz
- Jarosław Ruczyński
- Piotr Rekowski
- Piotr Rogujski
- Rafał Płatek
- Marta Barbara Wiśniewska
- Arkadiusz Piotrowski
- Łukasz Janus
- Piotr M. Skowron
- Michał Pikuła
- Paweł Sachadyn
- Sylwia Rodziewicz-Motowidło
- Artur Czupryn
- Piotr Mucha
2021 Pełny tekst INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose deprivation, oxidative stress, lactic acidosis, and excitotoxicity. Neurotoxicity of these peptides was excluded below a concentration of 50 μm, and PTD4-induced pro-survival was more pronounced. Circular dichroism spectroscopy and molecular dynamics (MD) calculations proved potential contribution of the peptide conformational properties to neuroprotection: in MD, Tat(49–57)-NH2 adopted a random coil and polyproline type II helical structure, whereas PTD4 adopted a helical structure. In an aqueous environment, the peptides mostly adopted a random coil conformation (PTD4) or a polyproline type II helical (Tat(49–57)-NH2) structure. In 30% TFE, PTD4 showed a tendency to adopt a helical structure. Overall, the pro-viable activity of PTD4 was not correlated with the arginine content but rather with the peptide’s ability to adopt a helical structure in the membrane-mimicking environment, which enhances its cell membrane permeability. PTD4 may act as a leader sequence in novel drugs for the treatment of acute ischemic stroke.
PTR-MS and electronic nose application for volatile fraction analysis of cigar tobacco
- Paweł Jacek Hać
- Julia Dobosz
- Łukasz Kołodziejski
- Bartłomiej Cieślik
- Piotr Konieczka
2021
Cigar consumers attach great importance to the quality of these products. At the same time, cigars are often expensive, so destructive analytical methods of quality control are not being desired. However, it has been found that there are many volatile organic compounds in their headspace. Because of that, proton transfer reaction–mass spectrometry and electronic nose were used to analyse it. The obtained results were used to distinguish between cigars of different quality.
Public Perception of Digital Contact Tracing App and Implications for Technology Acceptance and Use Models
- Adegboyega Ojo
- Nina Rizun
2021
Governments are increasingly adopting digital contact tracing applications (DCT) as a key component of their response to the COVID-19 pandemic. However, governments are struggling to achieve widespread adoption of DCT necessary for obtaining the expected individual and public benefits associated with its use. Consequently, studies on DCT have focused on the barriers to DCT adoption in different contexts and possible ways of overcoming some of the public concerns regarding the technology. Given the global nature of this innovation, this study explores extant literature and the public perception of DCT expressed in public tweets from different regions of the world. Our findings reveal emergent factors associated with the diffusion and adoption of the technology and enable us to better account for the ambivalent nature of DCT and its public-health innovation context in technology adoption models such as UTAUT.
Pulsed UV-irradiated Graphene Sensors for Ethanol Detection at Room Temperature
- Katarzyna Drozdowska
- Adil Rehman
- Pavlo Sai
- Bartłomiej Stonio
- Aleksandra Krajewska
- Grzegorz Cywiński
- Maciej Haras
- S. Rumyantsev
- Janusz Smulko
- Andrzej Kwiatkowski
2021 Pełny tekst
A graphene-based gas sensor fabricated in a FET (GFET) configuration and its sensitivity towards ethanol and methane is reported. Detection of ethanol at the level of 100 ppm was observed under pulsed UV irradiation and after cleaning by UV light in the N2 ambient. Reduction of the frequency of UV irradiation pulses resulted in increased changes in sensor resistance in the presence of ethanol. Improved sensing behavior was ascribed to more effective diffusion and adsorption processes at the graphene surface during low-frequency UV light pulses. Additionally, modulation of charge carrier density allowed more pronounced sensor responses at higher gate voltages (~30 V). GFET was insensitive to methane (200 ppm) at room temperature, regardless of irradiation frequency used, suggesting the potential application of selective gas sensing capability of graphene-based devices.
Pulse-Width Modulation of Power Electronic DC–AC Converter
- Atif Iqbal
- Arkadiusz Lewicki
- Marcin Morawiec
2021
The Second Edition of High Performance Control of AC Drives with Matlab®/Simulink delivers an updated and thorough overview of topics central to the understanding of AC motor drive systems. The book includes new material on medium voltage drives, covering state-of-the-art technologies and challenges in the industrial drive system, as well as their components, and control, current source inverter-based drives, PWM techniques for multilevel inverters, and low switching frequency modulation for voltage source inverters.
Pulse-Width Modulation Template for Five-Level Switch-Clamped H-Bridge-Based Cascaded Multilevel Inverter
- Charles Ikechukwu Odeh
- Dmytro Kondratenko
- Arkadiusz Lewicki
- Marcin Morawiec
- Andrzej Jąderko
- Janusz Baran
2021 Pełny tekst ENERGIES
This article presents a carrier-based pulse-width modulation (PWM) template for a 5-level, H bridge-based cascaded multilevel inverter (MLI). The developed control concept generates adequate modulation template for this inverter topology wherein a sinusoidal modulating waveform is modified to fit in a single triangular carrier signal range. With this modulation approach, classical multiplicity and synchronization of the triangular carrier signals criterion for the extension of sinusoidal pulse-width modulation, SPWM, to several cascaded 5-level, H-bridge-based MLI topology are removed. The proposed template can be used on the inverter configuration of any level with no further control modification. Nearly even distribution of switching pulses and equalized individual cascaded cell output power were achieved with the proposed modulation scheme. Three 5-level, H-bridge-based MLI units were cascaded for 1-phase, 13-level inverter operation; simulation and experimental results are adequately presented.
Pyrolysis of Pruning Residues from Various Types of Orchards and Pretreatment for Energetic Use of Biochar
- Paweł Kazimierski
- Paulina Hercel
- Tomasz Suchocki
- Jakub Smoliński
- Agnieszka Pladzyk
- Dariusz Kardaś
- Justyna Łuczak
- Katarzyna Januszewicz
2021 Pełny tekst Materials
The routine pruning and cutting of fruit trees provides a considerable amount of biowaste each year. This lignocellulosic biomass, mainly in the form of branches, trunks, rootstocks, and leaves, is a potential high-quality fuel, yet often is treated as waste. The results of a feasibility study on biochar production by pyrolysis of residues from orchard pruning were presented. Three types of biomass waste were selected as raw materials and were obtained from the most common fruit trees in Poland: apple (AP), pear (PR), and plum (PL) tree prunings. Two heating rates and three final pyrolysis temperatures were applied. For the slow (SP) and fast pyrolysis (FP) processes, the heating rates were 15 °C/min and 100 °C/min, respectively. The samples were heated from 25 °C up to 400, 500, and 600 °C. Chemical analyses of the raw materials were conducted, and the pyrolysis product yields were determined. A significant rise of higher heating value (HHV) was observed for the solid pyrolysis products, from approximately 23.45 MJ/kg for raw materials up to approximately 29.52 MJ/kg for pyrolysis products at 400 °C, and 30.53 MJ/kg for pyrolysis products at 600 °C. Higher carbon content was observed for materials obtained by fast pyrolysis conducted at higher temperatures
QUALITY GAPS IN HIGHER EDUCATION FROM THE PERSPECTIVE OF STUDENTS
- Piotr Grudowski
- Katarzyna, Szczepańska
2021 Pełny tekst Foundations of Management
The presented research work relates to the category of quality in higher education. This article aims to present the determinants of the quality of education in the context of international standards. The background of the considerations is the Bologna Declaration and the European Higher Education Area. The results of the research carried out with the use of the nominal group method and the data analysis carried out based on the SERVQUAL model for education revealed groups of quality determi-nants that are not included in the standards of internal quality assurance. It has been found that the prin-ciple of autonomy of universities in the European Higher Education Area is a sufficient basis to include the determinants of the quality of education identified by internal stakeholders of a given university in the internal quality of education assurance system.
Quality of Satellite Communication in Selected Mobile Android Smartphones
- Przemysław Falkowski-Gilski
2021 Pełny tekst Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
Today, thanks to mobile devices, satellite communication is available to anyone and everywhere. Gaining information on one’s position using GNSS (Global Navigation Satellite Systems), particularly in unknown urban environments, had become an everyday activity. With the widespread of mobile devices, particularly smartphones, each person can obtain information considering his or her location anytime and everywhere. This paper is focused on a study, considering the quality of satellite communication in case of selected mobile terminals. It describes a measurement campaign carried out in varying urban environments, including a set of Android-powered smartphones coming from different manufacturers. Based on this, respective conclusions and remarks are given, which can aid consumers as well as device manufacturers and application developers.
Quantitative fluorescent determination of DNA – Ochratoxin a interactions supported by nitrogen-vacancy rich nanodiamonds
- Wioleta Białobrzeska
- Maciej Głowacki
- Monika Janik
- Mateusz Ficek
- Krzysztof Pyrchla
- Sawczak Mirosław
- Robert Bogdanowicz
- Natalia Malinowska
- Sabina Żołędowska
- Dawid Nidzworski
2021 Pełny tekst JOURNAL OF MOLECULAR LIQUIDS
Ochratoxin A (OTA) is a hazardous contaminant of a large variety of plant and animal originated food. Herein, we report an interaction of OTA with calf thymus DNA (ct DNA) on the nanodiamond surface. We employed multispectroscopic techniques to elucidate the binding mechanism of OTA with ct DNA. The fluorescence and UV–Vis spectroscopy results show that OTA binds to ds ct DNA and forms complexes. We obtained the binding constants of OTA and ct DNA using fluorescence quenching and UV–Vis spectroscopy. The binding constant (Kb) for the interaction of OTA with ct DNA was determined using spectroscopic methods and was determined as 3.27 × 105 M−1 (UV–Vis) and 8.12 × 105 M−1 (fluorescence) for nanodiamond in green tea beverage OTA. Performed analyses directly indicate that OTA can interact with calf thymus DNA in a groove-binding mode as proved by the hyperchromic effect of the absorption spectra. This study of OTA–ct DNA interaction may provide novel insights into the toxicological effect of the mycotoxins.
Quantitative Risk Assessment in Construction Disputes Based on Machine Learning Tools
- Hubert Anysz
- Magdalena Apollo
- Beata Grzyl
2021 Pełny tekst Symmetry-Basel
A high monetary value of the construction projects is one of the reasons of frequent disputes between a general contractor (GC) and a client. A construction site is a unique, one-time, and single-product factory with many parties involved and dependent on each other. The organizational dependencies and their complexity make any fault or mistake propagate and influence the final result (delays, cost overruns). The constant will of the parties involved results in completing a construction object. The cost increase, over the expected level, may cause settlements between parties difficult and lead to disputes that often finish in a court. Such decision of taking a client to a court may influence the future relations with a client, the trademark of the GC, as well as, its finance. To ascertain the correctness of the decision of this kind, the machine learning tools as decision trees (DT) and artificial neural networks (ANN) are applied to predict the result of a dispute. The dataset of about 10 projects completed by an undisclosed contractor is analyzed. Based on that, a much bigger database is simulated for automated classifications onto the following two classes: a dispute won or lost. The accuracy of over 93% is achieved, and the reasoning based on results from DT and ANN is presented and analyzed. The novelty of the article is the usage of in-company data as the independent variables what makes the model tailored for a specific GC. Secondly, the calculation of the risk of wrong decisions based on machine learning tools predictions is introduced and discussed
Quantum and carbon dots conjugated molecularly imprinted polymers as advanced nanomaterials for selective recognition of analytes in environmental, food and biomedical applications
- Monika Sobiech
- Piotr Luliński
- Piotr Paweł Wieczorek
- Mariusz Marć
2021 TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Samples with complex matrix analyzed during explanation of pathogenesis of various diseases and food or environmental monitoring request advanced analytical and instrumental devices. Among the materials used for described purposes, quantum (QDs) or carbon dots (CDs) layered by molecularly imprinted polymer (MIP) shells have gained widespread attention. Unique optical and physicochemical properties of QDs/CDs together with high MIPs selectivity make the QD/CD-MIP conjugates capable of adsorbing specific target molecules e such a binding event is then transduced as the optical signal of the response by the QDs/CDs. This review includes brief introduction on principles of imprinting process, QD/CD properties and QD/CD-MIP preparation techniques. Then, recent advancement of QD/CD-MIP in bioanalysis including environmental, biological and food samples investigations are summarized and emphasized. Finally, current limits of QD/CD-MIPs are defined and prospects are outlined to intensify the capability of QD/CD-MIP in future bioanalytical procedures
Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
- Joanna Pilch
- Patrycja Kowalik
- Piotr Bujak
- Anna M. Nowicka
- Ewa Augustin
2021 Pełny tekst Nanomaterials
Nanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry and light microscopy) in lung H460 and colon HCT116 cancer cells. We show the time- dependent cellular uptake of QD–UA hybrids, which were more efficiently retained inside the cells compared to UAs alone, especially in H460 cells, which could be due to multiple endocytosis pathways. In contrast, in HCT116 cells, the hybrids were taken up only by one endocytosis mechanism. Both UAs and their hybrids induced apoptosis in H460 and HCT116 cells (to a greater extent in H460). Cells which did not die underwent senescence more efficiently following QDs–UAs treatment, compared to UAs alone. Cellular senescence was not observed in HCT116 cells following treatment with both UAs and their hybrids. Importantly, QDgreen/red themselves did not provoke toxic responses in cancer or normal cells. In conclusion, QDs are good candidates for targeted UA delivery carriers to cancer cells while protecting normal cells from toxic drug activities.
Quantum randomness protected against detection loophole attacks
- Piotr Mironowicz
- Gustavo Cañas
- Jaime Cariñe
- Esteban S. Gómez
- Johanna F. Barra
- Adán Cabello
- Guilherme B. Xavier
- Gustavo Lima
- Marcin Pawłowski
2021 Quantum Information Processing
Device and semi-device-independent private quantum randomness generators are crucial for applications requiring private randomness. However, they are vulnerable to detection inefficiency attacks and this limits severely their usage for practical purposes. Here, we present a method for protecting semi-device-independent private quantum randomness generators in prepare-and-measure scenarios against detection inefficiency attacks. The key idea is the introduction of a blocking device that adds failures in the communication between the preparation and measurement devices. We prove that, for any detection efficiency, there is a blocking rate that provides protection against these attacks. We experimentally demonstrate the generation of private randomness using weak coherent states and standard avalanche photo-detectors.
QUASI-DISTRIBUTED NETWORK OF LOW-COHERENCE FIBER-OPTIC FABRY-PÉROT SENSORS WITH CAVITY LENGTH-BASED ADDRESSING
- Katarzyna Karpienko
- Marcin Marzejon
- Adam Mazikowski
- Jerzy Pluciński
2021 Pełny tekst Metrology and Measurement Systems
Distributed measurement often relies on sensor networks. In this paper, we present the construction of low coherent fiber-optic Fabry-Pérot sensors connected into a quasi-distributed network. We discuss the mechanism of spectrum modulation in this type of sensor and the constraints of assembly of such sensors in the network. Particular attention was paid to separate the signals from individual sensors, which can be achieved by cavity length-based addressing. We designed and built a laboratory model of a temperature sensors network. The employed sensors are lowcoherence Fabry-Pérot interferometric sensors in fiber-optics configuration. The extrinsic sensor cavity utilizes the thermal expansion of ceramics, and the sensors are addressed by the different lengths of the cavities. The obtained test results show that the signal components from each sensor can be successfully separated, and the number of sensors could be expanded depending on the FWHM of the light source
Quasistatic and fatigue behavior of an AISI H13 steel obtained by additive manufacturing and conventional method
- José F. Garcias
- Rui F. Martins
- Ricardo Branco
- Zbigniew Marciniak
- Wojciech Macek
- Cândida Pereira
- Cyril Santos
2021 Pełny tekst FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES
This work aims to compare the mechanical behavior of an AISI H13 steel obtained by additive manufacturing with that obtained by conventional manufacturing methods. The average values of the ultimate tensile strength (UTS) and ductility obtained for the specimens produced by the conventional method were equal to 658 MPa and 18%, respectively, which compares with 503 MPa and 0.75% registered for the selective laser melting (SLM) specimens. Inversely, the average hardness value determined for the SLM specimens was higher, 450 HV, than the observed for the conventional, 200 HV. In addition, the maximum applied stress corresponding to a fatigue limit's endurance of 2 x 106 cycles was equal to 340 and 85 MPa for conventional and SLM specimens, respectively. Therefore, from a fatigue design point of view, it was possible to infer that σmax/UTS = 0.17 for the SLM specimens tested. Porosity and lack of fusion influenced the static and the fatigue strength negatively in the SLM specimens.
Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics
- Julia Borzyszkowska-Bukowska
- Justyna Górska
- Paweł Szczeblewski
- Tomasz Laskowski
- Iwona Gabriel
- Jakub Jurasz
- Katarzyna Kozłowska-Tylingo
- Piotr Szweda
- Sławomir Milewski
2021 Pełny tekst INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Three aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans to all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in the Candida albicans cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity. The molecular modeling studies on interactions between original antibiotics and their photoisomers with ergosterol and cholesterol revealed some difference in free energy profiles of formation of binary antibiotic/sterol complexes in respective membrane environments. Moreover, different geometries of heptaene: sterol complexes and variations in polyene macrolide molecule alignment in cholesterol- and ergosterol-containing membranes were found. None of these effects are of the crucial importance for the observed improvement of selective toxicity of aromatic heptaene antifungals but each seems to provide a partial contribution.
Racjonalność (w) ekonomii. Mapa problemu
- Andrzej Lisak
2021
Praca analizuje racjonalność zjawisk ekonomicznych w perspektywie całości funkcjonowania systemu społecznego, racjonalność podmiotu (homo oeconomicus), racjonalność samych zjawisk ekonomicznych oraz racjonalność ekonomi jako nauki. Stwarza to szerszą filozoficzną perspektywę rozumienia sensu zjawisk ekonomicznych w ludzkim życiu jak i lepsze zrozumienie problemu racjonalności.
Radar and Sonar Imaging and Processing (2nd Edition)
- Andrzej Stateczny
- Witold Kazimierski
- Krzysztof Kulpa
2021 Pełny tekst Remote Sensing
The 14 papers (from 29 submitted) published in the Special Issue “Radar and Sonar Imaging Processing (2nd Edition)” highlight a variety of topics related to remote sensing with radar and sonar sensors. The sequence of articles included in the SI deal with a broad profile of aspects of the use of radar and sonar images in line with the latest scientific trends, in which the latest developments in science, including artificial intelligence, were used.
Radiative lifetime of a BODIPY dye as calculated by TDDFT and EOM-CCSD methods: solvent and vibronic effects
- Rengel Cane Sia
- Ruben Arturo Arellano-Reyes
- Tia E. Keyes
- Julien Guthmuller
2021 Pełny tekst PHYSICAL CHEMISTRY CHEMICAL PHYSICS
The radiative emission lifetime and associated S1 excited state properties of a BODIPY dye are investigated with TDDFT and EOM-CCSD calculations. The effects of a solvent are described with the polarizable continuum model using the linear response (LR) approach as well as state-specific methods. The Franck–Condon (FC), Herzberg–Teller (HT) and Duschinsky vibronic effects are evaluated for the absorption and emission spectra, and for the radiative lifetime. The transition energies, spectra shapes and radiative lifetime are assessed with respect to experimental results. It is found that the TDDFT transition energies are overestimated by about 0.4–0.5 eV, whereas EOM-CCSD improves the vertical emission energy by about 0.1 eV in comparison to TDDFT. The solvatochromic and Stokes shifts are better reproduced by the state-specific solvation methods, which show that these methods are more suited than the LR model to describe the solvent effects on the BODIPY dye. The vibronic effects lead to an increase of the radiative lifetime of about 0.4 to 1.0 ns depending on the theoretical approach, which highlights the importance of such effects. Moreover, the HT effects are negligible on both the spectra and lifetime, which demonstrates that the FC approximation is accurate for the BODIPY dye. Finally, the comparison with experimental data shows that the radiative lifetimes predicted by EOM-CCSD and TDDFT have comparable accuracy.