2023 - Repozytorium publikacji - Politechnika Gdańska

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"Pejzaż malarstwa polskiego"
- Dominika Krechowicz
2023
Pejzaż malarstwa polskiego to szeroka i różnorodna prezentacja twórczości polskich współczesnych artystów, którzy przedstawią swoje najnowsze prace. Ekspozycja obejmie ponad 200 dzieł autorstwa 140 malarzy reprezentujących wszystkie aktualne nurty od realizmu i figuracji po abstrakcyjną sztukę bezprzedmiotową oraz obiekty. Na wystawie Pejzaż malarstwa polskiego obok siebie znajdą się prace uznanych klasyków współczesności, malarzy średniego pokolenia oraz najciekawszych młodych artystów i debiutantów. Malarze, którzy biorą udział w tym projekcie, reprezentują wszystkie najważniejsze w naszym kraju artystyczne uczelnie, ośrodki sztuki oraz kulturalne środowiska. Po prawie dwóch dekadach od pamiętnej wystawy Malarstwo polskie XXI wieku, Zachęta – Narodowa Galeria Sztuki zaprasza do obejrzenia ekspozycji Pejzaż malarstwa polskiego, która ponawia pytanie o rangę i miejsce w kulturze oraz przyszłość tej niezmiennie wiodącej dziedziny sztuk plastycznych. https://zacheta.art.pl/pl/wystawy/pejzaz-malarstwa-polskiego
Performance assessment of OpenMP constructs and benchmarks using modern compilers and multi-core CPUs
- Bartłomiej Gawrych
- Paweł Czarnul
2023
Considering ongoing developments of both modern CPUs, especially in the context of increasing numbers of cores, cache memory and architectures as well as compilers there is a constant need for benchmarking representative and frequently run workloads. The key metric is speed-up as the computational power of modern CPUs stems mainly from using multiple cores. In this paper, we show and discuss results from running codes such as: batch normalization, convolution, linear function, matrix multiplication, prime number test and wave equation; using compilers such as: GNU gcc, LLVM clang, icx, icc; run on four different 1 or 2-socket systems: 1 x Intel Core i7-5960X, 1 x Intel Core i9-9940X, 2 x Intel Xeon Platinum 8280L, 2 x Intel Xeon Gold 6130. Results can be regarded as suggestions concerning scaling on particular CPUs including recommended thread number configurations.
Performance Evaluation of Asphalt Binder Modified with Shear Thickening Fluid
- Tanveer Hassan
- Naveed Ahmad
- Diyar Khan
- Mohd Rosli Mohd Hasan
- Akhlaq Aman
- Umar Farooq
2023 JOURNAL OF MATERIALS IN CIVIL ENGINEERING
This paper aims at using a dilatant or shear thickening fluid (STF) [a non-Newtonian fluid consisting of particles of nano-silica suspended in a liquid medium, i.e., ethylene glycol (EG), which acts as a carrier fluid; proportion 40:60] as additive or modifier of bitumen in order to enhance its viscoelastic properties. A commonly-used performance grading (PG) system, storage stability test, and different conventional and rheological tests were carried out to optimize the dosage of the STF into the bitumen (investigating the influence of 2%, 4%, and 6% of STF on the bitumen) and to define the related properties. The results show that using 4% STF by weight of the binder (an asphalt binder with an 80/100 penetration grade) improves high-temperature viscoelastic properties and bitumen performance grading.
Performance of cryogenic oxygen production unit with exhaust gas bleed for sewage sludge gasification and different oxygen purities
- Maja Kaszuba
- Paweł Ziółkowski
- Dariusz Mikielewicz
2023 Pełny tekst Archives of Thermodynamics
The paper presents a thermodynamic analysis of the integration of a cryogenic air separation unit into a negative CO2 emission gas power plant. The power cycle utilizes sewage sludge as fuel so this system fits into the innovative idea of bioenergy with carbon capture and storage. A cryogenic air separation unit integrated with the power plant was simulated in professional plant engineering and thermodynamic process analysis software. Two cases of the thermodynamic cycle have been studied, namely with the exhaust bleed for fuel treatment and without it. The results of calculations indicate that the net efficiencies of the negative CO2 emission gas power plant reach 27.05% (combustion in 95.0% pure oxygen) and 24.57% (combustion in 99.5% pure oxygen) with the bleed. The efficiencies of the cycle without the bleed are 29.26% and 27.0% for combustion in 95.0% pure oxygen and 99.5% pure oxygen, respectively. For the mentioned cycle, the calculated energy penalty of oxygen production was 0.235 MWh/kgO2 for the lower purity value. However, for higher purity namely 99.5%, the energy penalty of oxygen production for the thermodynamic cycle including the bleed and excluding the bleed was indicated 0.346 and 0.347 MWh/kgO2,respectively.
Performance tuning of chitosan-based membranes by protonated 2-Pyrrolidone-5-carboxylic acid-sulfolane DES for effective water/ethanol separation by pervaporation
- Roberto Castro-Muñoz
- Łukasz Cichocki
- Maksymilian Plata-Gryl
- Grzegorz Boczkaj
- Francesco Galiano
2023 CHEMICAL ENGINEERING RESEARCH & DESIGN
Today, the applicability of deep eutectic solvents (DES) in various fields, including membrane science and technology, is extensively investigated. In pioneering works, we have implemented different DES as a component of chitosan (CS)-based flat membranes for pervaporation (PV) separation. Herein, we present a new protonated (by sulphuric acid) 2-Pyrrolidone-5-carboxylic acid: sulfolane DES, as a green additive for its chemical blending and thus study its effect in CS structure. The resultant flat CS-based membranes have been characterized and tested for their ability in separating water molecules from ethanolic mixtures (10 wt.% water in ethanol) using PV. Experiments revealed a progressive increase in total permeation along with increase of temperature in the range of 20 to 50°C. Simultaneously, the value of separation factor was reduced. The maximum permeation (approximately 0.44 kg m-2 h -1 ) was observed for the highest experimental temperature, in which water was the main component, while the highest separation factor (approximately 518) was observed for lowest operating temperature. It was confirmed that application of selected DES allowed to improve the permeation rates in comparison with the bare CS membrane. As a perspective, such membranes could be tested for another hydrophilic pervaporation applications for the removal of polar compounds – with high applicability in biorefineries.
Periodic and chaotic dynamics in a map‐based neuron model
- Frank Llovera Trujillo
- Justyna Signerska-Rynkowska
- Piotr Bartłomiejczyk
2023 Pełny tekst MATHEMATICAL METHODS IN THE APPLIED SCIENCES
Map-based neuron models are an important tool in modeling neural dynamics and sometimes can be considered as an alternative to usually computationally costlier models based on continuous or hybrid dynamical systems. However, due to their discrete nature, rigorous mathematical analysis might be challenging. We study a discrete model of neuronal dynamics introduced by Chialvo in 1995. In particular, we show that its reduced one-dimensional version can be treated as an independent simple model of neural activity where the input and the fixed value of the recovery variable are parameters. This one-dimensional model still displays very rich and varied dynamics. Using the fact that the map whose iterates define voltage dynamics is S-unimodal, we describe in detail both the periodic behavior and the occurrence of different notions of chaos, indicating corresponding regions in parameter space. Our study is also complemented by a bifurcation analysis of the mentioned dynamical model.
Permeability of sandy soils estimated from particle size distribution and field measurements
- Wioletta Gorczewska-Langner
- Anna Gumuła-Kawęcka
- Beata Jaworska-Szulc
- Rafael Angulo-Jaramillo
- Adam Szymkiewicz
2023 Pełny tekst Archives of Civil Engineering
Accurate estimation of soil permeability is crucial in many geotechnical applications. Empirical and theoretical equations based on soil particle size distribution (PSD) offer a fast and cheap way for preliminary estimation of permeability in granular soils, however the results obtained from various formulas available in the literature often show significant discrepancies. While several comparative studies on this topic have been published, no definite conclusions can be drawn on the performance of the predictive equations in comparison with in-situ permeability measurements. Many formulas require porosity or void ratio as input parameter, which is difficult to obtain for granular soil in-situ. In this study we applied 30 predictive equations to estimate permeability of sandy soil in an outwash plain deposit. The equations were divided into 5 groups, based on their structure and the required input parameters. Empirical formulas were used to estimate the expected in-situ porosity range. The obtained permeability values were compared to the results of in-situ permeameter measurements and pumping tests. Significant differences in the results and in their sensitivity to porosity were found between the 5 groups of methods. In general, simple equations which do not include porosity were in better agreement with measurements than the other groups.
Peroxymonosulfate-assisted photocatalytic degradation of artificial sweeteners in water
- Jakub Smoliński
- Agnieszka Fiszka Borzyszkowska
- Paweł Kubica
- Anna Zielińska-Jurek
2023 Pełny tekst Chemical and Process Engineering : New Frontiers
In the present study, peroxymonosulfate (PMS) activation was proposed for efficient photocatalytic degradation of aspartame, acesulfame, saccharin, and cyclamate - artificial sweeteners frequently present in wastewaters and surface waters worldwide. The TiO2 nanosheets with exposed {0 0 1} facets were synthesised using the fluorine-free lyophilisation technique as a green concept for the synthesis and used for the photodegradation of selected sweeteners not susceptible to biodegradation. The synergetic effect of photocatalysis with the sulfate radical-based process was for the first time investigated. It was found that the studied artificial sweeteners were practically not susceptible to photolysis within 60 minutes of irradiation. In the presence of 2D titanium (IV) oxide, the artificial sweeteners were degraded entirely in less than 30 min, whereas the addition of peroxymonosulfate resulted in complete degradation after 10 – 15 minutes of the process.
Persistences: analysis of the image of Gdańsk and its cultural identity through survey processes and digital architectural representation
- Sandro Parrinello
- Justyna Borucka
- Jakub Szczepański
- Francesca Picchio
2023
The aim of the research was to analyse the historical legacy/heritage of the city of Gdańsk in order to characterise the narrative tools which can be used to promote the cultural identity of the urban landscape. The main focus was on the city's defence system - a cultural route that is spatially limited to a relatively small area, but temporally spanning almost a millennium. The fortifications demarcate a spatial boundary, limiting the urban layout, which has remained distinguishable over the centuries, however changing its image. The research activities have been carried out by a multidisciplinary group of scholars participating in the H2020 PROMETHEUS European project aimed at developing innovative methodologies for digitising architecture with the integration of multidisciplinary data and information models, leading to specialised figures capable of operating on heritage built assets. The image of the city and the urban landscape is transforming in an attempt to strengthen its historical identity. In each century, new architectural and formal models are introduced, which become integrated with the structural characteristics of the urban layout, altering the urban space. Today, in the digital age, it is becoming strategic not only to convert architecture and its models, but also to make the urban image more explicit, trying to translate the invariants of the landscape into the 3D digital databases.
Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
- Krystian Zieliński
- Sebastian Pukszta
- Małgorzata Mickiewicz
- Marta Kotlarz
- Piotr Wygocki
- Marcin Zieleń
- Dominika Drzewiecka
- Damian Drzyzga
- Anna Kloska
- Joanna Jakóbkiewicz-Banecka
2023 Pełny tekst PLoS Computational Biology
Controlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched to groups of various MII oocyte counts using ranking, correspondence analysis, and self-organizing map methods. The gradient boosting machine technique was used to train models on a clinical dataset of 8,574 or a clinical-genetic dataset of 516 ovarian stimulations. The clinical-genetic model predicted the number of MII oocytes better than that based on clinical data. Anti-Müllerian hormone level and antral follicle count were the two most important predictors while a genetic feature consisting of sequence variants in the GDF9, LHCGR, FSHB, ESR1, and ESR2 genes was the third. The combined contribution of genetic features important for the prediction was over one-third of that revealed for anti-Müllerian hormone. Predictions of our clinical-genetic model accurately matched individuals’ actual outcomes preventing over- or underestimation. The genetic data upgrades the personalized prediction of ovarian stimulation outcomes, thus improving the in vitro fertilization procedure.
‘Personas for lighting’. Three methods to develop personas for the indoor lighting environment
- Natalia Sokół
- Justyna Martyniuk-Pęczek
- Barbara Matusiak
- Claudia Naves David Amorim
- Marta Waczynska
- Julia Kurek
- Natalia Giraldo Vasquez
- Sergio Sibilio
- Julia Kanno
- Michelangelo Scorpio
- Marzieh Nazari
- Yasuko Koga
2023 Pełny tekst ENERGY AND BUILDINGS
The objective of this research is to describe and compare three different methods of generating ‘persona for lighting’ to envision users’ behaviour within the lighting environment. ‘Personas’ are used to represent typical users, highlighting their needs, perspectives, and expectations to aid user-centric design approaches. The researchers looked for the most useful method of shaping ‘personas for lighting’ to learn about users’ satisfaction with the various lighting conditions to identify their needs. Method one of lighting persona development, was based on interviews with 87 users of five buildings of four different types: an office, a primary school, two university buildings, and a factory. The lighting conditions were observed and measured in all the buildings. As a result, 22 personas for lighting were created. In method two personas were generated based on pre-interviews, workshops on lighting and post-interviews with ten users along with the onsite lighting measurements. Later, due to the Covid-19 pandemic’s lockdowns, an online survey on the visual lighting environment in home offices was carried out among 694 students and professionals from seven countries to create two more personas for lighting (method three). All 26 ‘personas for lighting’ were generated in relation to observed lighting conditions, based on the satisfaction, preferences and needs of the users working within variously lit indoor environments. All the tested methods can be used for nearly any type of building and room, but the resulting personas are different due to the specific limitations of the methods. The created personas may help to identify future users’ lighting preferences, needs and requirements and assist designers. However, to fully understand their impact on the lighting research practice they should be tested in real projects
Phage Therapy—Challenges, Opportunities and Future Prospects
- Beata Zalewska-Piątek
2023 Pełny tekst Pharmaceuticals
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly. Phages that selectively infect and kill bacteria are often the only life-saving therapeutic option. Full legalization of this treatment method could help solve the problem of multidrug-resistant infectious diseases on a global scale. The aim of this review is to present the prospects for the development of phage therapy, the ethical and legal aspects of this form of treatment given the current situation of such therapy, and the benefits of using phage products in persons for whom available therapeutic options have been exhausted or do not exist at all. In addition, the challenges faced by this form of therapy in the fight against bacterial infections are also described. More clinical studies are needed to expand knowledge about phages, their dosage, and a standardized delivery system. These activities are necessary to ensure that phage-based therapy does not take the form of an experiment but is a standard medical treatment. Bacterial viruses will probably not become a miracle cure—a panacea for infections—but they have a chance to find an important place in medicine.
Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
- Karolina Kaźmierczak-Siedlecka
- Nikola Bulman
- Paweł Ulasiński
- Bartosz Kamil Sobocki
- Karol Polom
- Luigi Marano
- Leszek Kalinowski
- Karolina Skonieczna-Żydecka
2023 Pełny tekst Gut Microbes
Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively gathered scientific evidence on the interplay between anticancer therapies and gut microbes. We also underlined how such interactions might impact the host response to a given therapy. We discuss the possibility of modulating the gut microbiota to increase the effectiveness/decrease the incidence of adverse events during tumor therapy. The anticipation of the future brings new evidence that gut microbiota is a target of interest to increase the efficacy of therapy.
Philosophy of Symbolic Forms and a Mystery of “Appearing Itself ”. Cassirer in the Context of Phenomenology
- Przemysław Parszutowicz
2023
in the publications concerning Cassirer, whose number has been increasing for about a dozen years, more and more space is devoted to the genesis of his philosophy, and more attention is paid to its linkage to Neo-Kantian Marburg school. Also, in addition to Kantian, Hegelian and Goethean heritage in Cassirer’s philosophy is indicated, while its discovered philosophical foundations make it possible to regard the author of The Philosophy of Symbolic Forms not only as a historian and theoretician of philosophy and culture, but also as the creator of an original philosophical system, where motifs referring to metaphysics can also be found, and which is founded on phenomenology understood in a specific way.
Phosphinoborenium cations stabilized by N-heterocyclic carbenes: synthesis, structure, and reactivity
- Kinga Kaniewska-Laskowska
- Anna Ordyszewska
- Tomasz Wojnowski
- Hanna Halenka
- Marcin Czapla
- Jarosław Chojnacki
- Rafał Grubba
2023 Pełny tekst DALTON TRANSACTIONS
Phosphinoborenium cations stabilized by N-heterocyclic carbenes (NHCs) were synthesized via the reaction of bromo(phosphino)boranes with NHCs. Their structures were investigated by heteronuclear magnetic resonance spectroscopy, X-ray diffraction, and density functional theory calculations. They possess a planar trigonal boron center directly bonded with the pyramidal phosphanyl group (PR2) and can be treated as cationic phosphinoboranes. The reactivity of the selected NHC-phosphinoborenium cation was tested toward AuCl·SMe2 and Ph2PCl. In both reactions, the titled compound acted as a phosphido group donor under heterolytic cleavage of the P–B bond. Control experiments with parent phosphinoborane emphasized differences between the reactivity of low-coordinate neutral and cationic species with P–B functionality.
Photocatalytic activity of zinc oxide nanorods incorporated graphitic carbon nitride catalyst
- Shanmugapriya Dharani
- Arunachalam Saravana Vadivu
- Anna Zielińska-Jurek
- Arunachalam Chinnathambi
- Md Ramesh
- Matias Soto-Moscoso
2023 Journal of the Taiwan Institute of Chemical Engineers
Background Photocatalysts are user-friendly and serve as compatible materials for degrading industrial dye pollutants. This study utilizes zinc oxide/graphitic carbon nitride (ZnO/g-C3N4) nanocomposites against degrading methylene blue (MB). Methods The hydrothermal method assisted sonication technique was used to fabricate the ZnO/g-C3N4 composite with varying ratios of ZnO/g-C3N4 (1:0.25, 1:0.50, 1:1). The synthesized materials have undergone various sophisticated techniques for finding their physiochemical properties and have been utilized for photodegradation activities. Significant findings The characterized results exhibit that the nanoflakes of g-C3N4 were covered with nanorods of zinc oxide when observed through scanning electron microscopy (SEM). Furthermore, the X-ray diffraction (XRD) studies demonstrate that the ZnO/g-C3N4 material was successfully synthesized. The X-ray photoelectron spectra (XPS) and Fourier-transform infrared (FTIR) spectra revealed the present oxidation states and chemical bonding of the materials. The photocatalytic activity results demonstrated that the concentration of ZnO molar ratio in varying g-C3N4 significantly affected the decomposition performance. The ZnO/g-C3N4 (1:0.50) presented a higher rate of degradation, reaching 92% at 120 minutes under UV light and 65% at 240 minutes under visible light irradiation. This could be explained by the mechanism that follows the separation of charge carriers, thereby producing hydroxyl radicals for the effective degradation of MB pollutants.
Photocatalytic decolourization of Rhodamine-B dye by visible light active ZIF-8/BiFeO3 composite
- Bhaskar Bethi
- Gidla Bhanu Radhika
- Le Minh Thang
- Shirish H. Sonawane
- Grzegorz Boczkaj
2023 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
In this work, preparation of ZIF-8 supported BiFeO3 photocatalyst by ultrasound cavitation technique was reported. The synthesized materials were characterized using solid UV absorption spectroscopy, Raman Spectroscopy, and SEM. The catalytic function of synthesized photocatalyst under ultraviolet and visible light was examined for the decolourization of Rhodamine-B (Rh-B) dye. To understand the action of the photocatalyst on Rh-B decolorization, the influence of different operating parameters such as wt% of ZIF-8 in composite, catalyst dosage, initial dye concentration, initial solution pH, and source of light was examined. The obtained results show that 40.7 wt% of ZIF-8/BiFeO3 composite exhibited the highest possible photocatalytic behaviour against decolorization of Rh-B dye. The acidic pH of the solution had shown greater effectiveness in removing Rh-B dye. The tests and study demonstrate that the hybrid ZIF-8/BiFeO3 has a stronger photocatalytic activity for decolorization of the Rh-B dye relative to the ZIF-8 MOF and BiFeO3. The synthesized ZIF-8/BiFeO3 demonstrated outstanding photocatalytic behaviour in the presence of ultraviolet and visible light towards the removal of Rh-B dye from the aqueous media.
Photocatalytic degradation and pollutant-oriented structure-activity analysis of carbamazepine, ibuprofen and acetaminophen over faceted TiO2
- Szymon Dudziak
- Agnieszka Fiszka Borzyszkowska
- Anna Zielińska-Jurek
2023 Journal of Environmental Chemical Engineering
Photocatalytic degradation of carbamazepine, ibuprofen, acetaminophen and phenol was studied in the presence of anatase photocatalyst, exposing three different crystal facets in the majority of {0 0 1}, {1 0 0} or {1 0 1}. It was found that octahedral anatase particles exposing {1 0 1} facets allow to achieve the best degradation and mineralization of all persistent organic pollutants. This confirms that the previous findings, showing high {1 0 1} activity, are not limited to phenol and could be generalized for other water pollutants. Based on the obtained results, a correlation model including exposed TiO2 crystal facet and chemical hardness of the pollutant was developed to predict the degradation rate of pollutants with a possibly diverse electronic structure. The structureactivity analyses, based on the reactivity predictors obtained from the DFT calculations for all tested compounds, have shown that pollutants with higher chemical hardness react faster with the photocatalyst. Alternatively, a similar effect was observed for the higher HOMO-LUMO energy gap of the compound. This relation indicates that for compounds with a low energy position of LUMO orbital, e.g., carbamazepine, process efficiency is not strictly dependent on the stability of h+ generated organic radical, which is often pointed out as an initial reactive form. Based on these results, a correlation model was developed for the first time to quantitatively describe the effect of the facet-pollutant interactions based on their independent electronic properties. Finally, this was followed by the detailed degradation study of the pharmaceuticals mixture, showing the impact of the total concentration and role of active species on the degradation efficiency over facet-engineered TiO2 photocatalysts.
Photocatalytic hydrogen evolution from glycerol-water mixture under visible light over zinc indium sulfide (ZnIn2S4) nanosheets grown on bismuth oxychloride (BiOCl) microplates
- Onur Cavdar
- Mateusz Baluk
- Anna Malankowska
- Andrzej Zak
- Wojciech Lisowski
- Tomasz Klimczuk
- Adriana Zaleska-Medynska
- Mateusz Adam Baluk
2023 JOURNAL OF COLLOID AND INTERFACE SCIENCE
ZnIn2S4 (ZIS) is one of the widely studied photocatalyst for photocatalytic hydrogen evolution applications due to its prominent visible light response and strong reduction ability. However, its photocatalytic glycerol reforming performance for hydrogen evolution has never been reported. Herein, the visible light driven BiOCl@ZnIn2S4 (BiOCl@ZIS) composite was synthesized by growth of ZIS nanosheets on a template-like hydrothermally pre-prepared wide-band-gap BiOCl microplates using simple oil-bath method to be used for the first time for photocatalytic glycerol reforming for photocatalytic hydrogen evolution (PHE) under visible light irradiation (k > 420 nm). The optimum amount of BiOCl microplates in the composite was found 4 wt% (4% BiOCl@ZIS) in the presence of in-situ 1 wt% Pt deposition. Then, the in-situ Pt photodeposition optimization studies over 4% BiOCl@ZIS composite showed the highest PHE rate of 674 lmol g-1h1 with the ultra-low platinum amount (0.0625 wt%). The possible mechanisms behind this improvement can be ascribed to the formation of Bi2S3 low-band-gap semiconductor during BiOCl@ZIS composite synthesis resulting in Z-scheme charge transfer mechanism between ZIS and Bi2S3 upon visible light irradiation. This work expresses not only the photocatalytic glycerol reforming over ZIS photocatalyst but also a solid proof of the contribution of wide-band-gap BiOCl photocatalysts to enhancement of ZIS PHE performance under visible light.
Photonic sensor to detect rapid changes in CRP levels
- Małgorzata Szczerska
- Monika Kosowska
- Roman Viter
- Paweł Wityk
2023 Pełny tekst Journal of Biophotonics
One of the most important biomarkers used to determine inflammation is C-reactive protein (CRP). Its level, when it is within the range that does not define inflammation, informs about the risk of cardiovascular events. If the norm is exceeded and inflammation is detected in the body, CRP level can increase 1000 times within a few hours. The type of infection can also be determined based on the level of elevated CRP. All this makes CRP a very important element of diagnostics. A sensor based on low coherence interference is presented. Preliminary studies have shown that its sensitivity is 5.65 μg/L and the measurement time is short, <10 min. The entire system is built of commercially available components, which allow production cost minimalization. In addition, the user-friendly operation allows it to be operated by unqualified people. Due to these features, our solution is a promising alternative to commercially used enzyme-linked immunosorbent assay, which needs trained personnel to perform time-consuming measurement procedures.