2024 - Repozytorium publikacji - Politechnika Gdańska

Pokaż publikacje z roku

Publikacje z roku 2024

Pokaż wszystkie

Supramolecular deep eutectic solvents in extraction processes: a review
- Patrycja Makoś-Chełstowska
- Edyta Słupek
- Sophie Fourmentin
- Jacek Gębicki
2024 Environmental Chemistry Letters
Solvent selection is essential for industrial and analytical extraction processes to ensure environmental safety and neutrality. Nevertheless, toxic and hazardous solvents are often used, due to their cost-effectiveness and ready availability. In green chemistry, alternative solvents such as supramolecular deep eutectic solvents are gaining attention due to their superior performance compared with traditional non-green solvents in certain applications. Here we review the use of supramolecular deep eutectic solvents as a green solvent for analytical and industrial liquid–liquid extraction processes, with focus on physicochemical properties, extraction conditions, the capacity factor, the enrichment factor, fuel desulfurization, extraction of biological active compounds, lignin valorization, and sample preparation.
Surface finite viscoelasticity and surface anti-plane waves
- Victor Eremeev
2024 Pełny tekst INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
We introduce the surface viscoelasticity under finite deformations. The theory is straightforward generalization of the Gurtin–Murdoch model to materials with fading memory. Surface viscoelasticity may reflect some surface related creep/stress relaxation phenomena observed at small scales. Discussed model could also describe thin inelastic coatings or thin interfacial layers. The constitutive equations for surface stresses are proposed. As an example we discuss propagation shear (anti-plane) waves in media with surface stresses taking into account viscoelastic effects. Here we analysed surface waves in an elastic half-space with viscoelastic coatings. Dispersion relations were derived.
Surprising Radiolytic Stability of 8‑Thiomethyladenine in an Aqueous Solution
- Magdalena Datta
- Adrian Szczyrba
- Magdalena Zdrowowicz
- Dariusz Wyrzykowski
- Olga Ciupak
- Sebastian Demkowicz
- Farhad Izadi
- Stephan Denifl
- Janusz Rak
2024 Pełny tekst JOURNAL OF PHYSICAL CHEMISTRY B
8-Thiomethyladenine (ASCH3), a potentially radiosensitizing modified nucleobase, has been synthesized in a reaction between 8-thioadenine and methyl iodide. Despite favorable dissociative electron attachment (DEA) characteristics, the radiolysis of an aqueous solution of ASCH3 with a dose of X-ray amounting to as much as 300 Gy leads to no effects. Nevertheless, crossed electron-molecule beam experiments in the gas phase on ASCH3 confirm the theoretical findings regarding the stability of its radical anion, namely, the most abundant reaction channel is related to the dissociation of the S-CH3 bond in the respective anion. Furthermore, electroninduced degradation of ASCH3 has been observed in aprotic acetonitrile, which is strong evidence for the involvement of proton transfer (PT) in stabilizing the radical anion in an aqueous solution. These findings demonstrate that PT in water can be the main player in deciding the radiosensitizing properties of modified nucleobases/nucleosides.
Survey of ICT students' views on self-assessment of professional preparation after remote study
- Marta Szczerska
- Michał Tomczak
- Paweł Ziemiański
- Katarzyna Wajszczyk
2024 Edukacja Ustawiczna Dorosłych
The contemporary post-pandemic reality is characterised by an undisputable shift toward remote education and work. The aim of this article is to identify the assessment of ICT evaluation of different forms of study, including desktop, remote and hybrid forms; to find out their preferences towards different forms of education and work, and to determine their sense of self-efficacy in terms of professional tasks undertaken after remote education. A survey method was used and the research sample was based on purposive sampling. The results indicate that, although a hybrid environment is preferred in both educational and professional contexts, the challenge remains to optimise this format in order to improve the quality of education. Nevertheless, the surveyed students feel self-efficacious in their professional activities after remote education.
Suspension and process parameters selection for electrophoretic deposition of Mn–Co spinel coating on steel interconnects
- Omid Ekhlasiosgouei
- Federico Smeacetto
- Sebastian Molin
2024 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
Metallic interconnect coatings, consisting of MnCo2O4 spinel, were effectively applied to Crofer 22 APU using the electrophoretic deposition (EPD) method in both H2O: ethanol and pure ethanol solvents. The primary goal of this method was to prevent chromium migration, minimize evaporation, and control the oxidation rate. The study aimed to assess the quality, adhesion, and thickness of the Mn–Co coating, with the objective of achieving a consistent and uniform layer. The results indicated a preference for pure ethanol solvent over H2O: ethanol (40:60 %Vol) for Mn–Co particles. Furthermore, the agglomeration of Mn–Co particles was notably lower (approximately 7 times) in ethanol compared to H2O: ethanol. The morphology and surface roughness of the sintered Mn–Co coating on the alloy were examined using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). A uniform and dense coating was successfully attained using pure ethanol solvent at a solid concentration of 10 g/L, with 0.5 g/L of iodine serving as a disperser. The deposition process, carried out at a voltage of 30V for 20 s, resulted in a coating with a thickness of 7.4 ± 0.3 μm and a surface roughness of 0.75 ± 0.5 μm.
Sustainable chemically modified poly(butylene adipate-co-terephthalate)/thermoplastic starch/poly(ε-caprolactone)/cellulose biocomposites: looking at the bulk through the surface
- Aleksander Hejna
- Mateusz Barczewski
- Paulina Kosmela
- Olga Mysiukiewicz
- Agnieszka Tercjak
- Adam Piasecki
- Mohammad Saeb
- Marek Szostak
2024 JOURNAL OF MATERIALS SCIENCE
Sustainable polymer composites (or biocomposites) based on renewable and green polymers are progressively under development in a technological paradigm shift from “just use more and more” to “convert into value-added products”. Therefore, significant efforts should focus not only on their reduced environmental impact but also on maximizing their performance and broadening their application range. Herein, the bio-based blends based on Mater-Bi bio-plastic and poly(ε-caprolactone), at a weight ratio of 70:30, were developed, followed by the addition of UFC100 cellulose filler to yield sustainable biocomposites. The effects of cellulose chemical modification with three diisocyanates, i.e., hexamethylene diisocyanate (HDI), methylene diphenyl isocyanate (MDI), or toluene diisocyanate (TDI) on the surface properties of biocomposites were evaluated by water contact angle and surface roughness detected by atomic force microscopy (AFM). Biocomposites containing cellulose modified with HDI, MDI, or TDI revealed contact angle values of 93.5°, 97.7°, and 92.4°, respectively, compared to 88.5° for reference blend, indicating an enlarged hydrophobicity window. This action was further confirmed by increased fracture surface roughness and miscibility detected by microscopic observation (scanning electron microscopy (SEM) and AFM). An in-depth oscillatory rheological evaluation has identified MDI, followed by TDI, as the most efficient compatibilizer of the analyzed system. Correspondingly, thermogravimetric analysis and differential scanning calorimetry analyses showed more residue and higher melting temperatures for biocomposites, more promisingly with MDI and TDI modifiers. In conclusion, either incorporation or diisocyanate modification of cellulose affects both surface and bulk properties, providing vital insights into future developments in the field. Proper selection of diisocyanate modifier of cellulose may enable engineering of composites performance.
Sustainable energy consumption – Empirical evidence of a household in Poland
- Ewelina Sokołowska
- Jerzy Wiśniewski
2024 Pełny tekst Energy Strategy Reviews
There is an expected increase in the demand for electricity from households in European countries. The outcome of the growing proportion of renewable energy sources in the energy supply mix should result in improved customer awareness regarding their electricity usage. Additionally, they must assume a more proactive role in overseeing their electricity usage. Innovation and pollution management have become crucial catalysts for promoting sustainable economic development and environmental protection. This is a response to the increasing threats posed by climate change. This study addresses this existing research gap in sustainable energy consumption. The research aims to examine the advantages of replacing traditional sources of heating with renewable ones. The empirical case study of households in Poland serves as an illustration of the theoretical foundation. The purpose of the study entails the construction of a multi-equation econometric model describing the mechanisms of electricity consumption in a specific household. The model hypothesis indicates that the model should take the form of a system of interdependent equations. The following will be described: the monthly volume of electricity consumption, the cost of this energy payment (in PLN), and the price per one MWh in a given month. Monthly time series from September 2015 to June 2023 were used. The resulting time series amounted to a count of 94 statistical observations. The results in the form of a multi-level empirical econometric model indicate that the economic, environmental, and social benefits of using renewable sources of heating can make a significant contribution to reducing fossil fuel consumption and CO2 emissions. In the context of growing environmental awareness and the need to reduce greenhouse gas emissions, heat pumps are becoming an increasingly important element in the discussion of the future of heating. Their role in transforming the energy sector in the direction of sustainability is crucial.
Sustainable Management of Food Wastes Through Cavitation-Assisted Conversion into Value-Added Products
- Zahra Askarniya
- Xun Sun
- Chongqing Wang
- Grzegorz Boczkaj
2024
More than 30% of worldwide food consumption is thrown out as food wastes causing serious environmental, economic, and social problems. Therefore, it is required to develop sustainable food waste management methods leading to an enhancement in social and economic benefits and mitigation of environmental impacts. Anaerobic digestion can be regarded as one of those effective methods that can be employed for the conversion of food waste to value-added products. Food wastes are normally resistant towards hydrolysis (the first stage of anaerobic digestion), leading to a reduction in the formation of desired products. Cavitation is one of the useful pretreatment methods that can mitigate this problem and also increase mass transfer, which is a severe barrier to the reaction producing biodiesel (transesterification), leading to high rates of hydrolysis and transesterification. Cavitation is the formation, growth, and collapse of bubbles formed in the solution. Considering the subsequent effect of the collapse of generated bubbles (ability to disintegrate solid material, turbulence, high temperature and pressure, and radical formation), cavitation can be considered an efficient technique for minimizing the time and optimizing the generation of valuable products from food wastes. This technology can cause microbes to easily access substrates, resulting in an enhancement in microbial growth and the formation of products. Additionally, it can increase mass transfer between reactants, decreasing the time required in transesterification for producing biodiesel.
Symbolic multibody models for digital-twin applications
- Nicolas Docquier
- Krzysztof Lipiński
- Olivier Lantsoght
- Sebastien Timmermans
- Paul Fisette
2024 MULTIBODY SYSTEM DYNAMICS
Symbolic generation of multibody systems equations of motion appeared in the 1980s. In addition to their computational advantage over their numerical counterparts, symbolic models can be very easily and straightforwardly interfaced with a wide range of software environments and hardware devices. These two features place this approach in a pole position to participate and intervene in the design of digital twins for systems such as vehicles, manipulators, walking robots or haptic devices. In this context, the first goal of this paper is to highlight the interest of symbolically generated multibody models – at the root of the ROBOTRAN program – in the form of a standalone set of equations calculating the dynamic model of multibody systems, for use as a computational component within a Digital-Twin-type process. The next goal is to embed realistic and complex multibody models within processes or devices whose functioning requires a synchronized real-time computation – or analysis – of their motion. An implementation (i) on specific hardware and (ii) on two extremely opposite but revealing applications (namely a railway vehicle and a digital piano) are presented to highlight the usefulness of symbolic models for the development of current and future multibody-based digital twins.
Synergism of floated paperboard sludge cake /sewage sludge for maximizing biomethane yield and biochar recovery from digestate: A step towards circular economy
- Rania H. Hafez
- Ahmed Tawfik
- Gamal K. Hassan
- Magdy Zahran
- Ahmed A. Younes
- Aleksandra Ziembińska-Buczyńska
- Filip Gamoń
- Mahmoud Nasr
2024 CHEMOSPHERE
Anaerobic digestion of floated paperboard sludge (PS) cake suffers from volatile fatty acids (VFAs) accumulation, nutrient unbalanced condition, and generation of digestate with a risk of secondary pollution. To overcome these drawbacks, sewage sludge (SS) was added to PS cake for biogas recovery improvement under a co-digestion process followed by the thermal treatment of solid fraction of digestate for biochar production. Batch experimental assays were conducted at different SS:PS mixing ratios of 70:30, 50:50, 30:70, and 20:80 (w/w), and their anaerobic co-digestion performances were compared to the mono-digestion systems at 35±0.2 °C for 45 days. The highest methane yield (MY) of 241.68±14.81 mL/g CODremoved was obtained at the optimum SS:PS ratio of 50:50 (w/w). This experimental condition was accompanied by protein, carbohydrate, and VFA conversion efficiencies of 47.3±3.2%, 46.8±3.2%, and 56.3±3.8%, respectively. The synergistic effect of SS and PS cake encouraged the dominance of Bacteroidota (23.19%), Proteobacteria (49.65%), Patescibacteria (8.12%), and Acidovorax (12.60%) responsible for hydrolyzing the complex organic compounds and converting the VFAs into biomethane. Further, the solid fraction of digestate was subjected to thermal treatment at a temperature of 500 °C for 2.0 h, under an oxygen-limited condition. The obtained biochar had a yield of 0.48 g/g dry digestate, and its oxygen-to-carbon (O/C), carbon-to-nitrogen (C/N), and carbon-to-phosphorous (C/P) ratios were 0.55, 10.23, and 16.42, respectively. A combined anaerobic co-digestion/pyrolysis system (capacity 50 m3/d) was designed based on the COD mass balance experimental data and biogenic CO2 market price of 22 USD/ton. This project could earn profits from biogas (12565 USD/yr), biochar (6641 USD/yr), carbon credit (8014 USD/yr), and COD shadow price (6932 USD/yr). The proposed project could maintain a payback period of 6.60 yr. However, further studies are required to determine the associated life cycle cost model that is useful to validate the batch experiment assumptions.
Synergistic effects of a swirl generator and MXene/ water nanofluids used in a heat exchanger pipe of a negative CO2 emission gas power plant
- Milad Amiri
- Paweł Ziółkowski
- Dariusz Mikielewicz
2024 NUMERICAL HEAT TRANSFER PART A-APPLICATIONS
focus on optimizing heat exchangers contributes to improved temperature control mechanisms, ensuring the sustainable operation of innovative power plants working towards negative CO2 emissions. In the realm of oxy-combustion within Negative CO2 Emission Power Plants (nCO2PP), the temperature of combustion products surpasses 3000 (K). Addressing this challenge, the imperative arises to reduce these elevated temperatures to a manageable 1100(°C). This critical cooling process is achieved through the injection of water, facilitated by the implementation of heat exchangers. The study delves into the optimization of heat transfer within the heat exchanger pipe, specifically tailored for the context of a Negative CO2 Emission Power Plant. Employing a numerical simulation, the investigation explores the impact of vortex generator geometry, vane angles, single and dual propeller-type swirl generators, and the integration of a novel class of fluid, MXene/water nanofluid. Initially, the study scrutinizes propeller-type geometry at vane angles spanning from 15 to 60 degrees. The enhanced swirl flow associated with lower vane angles leads to improved fluid mixing, fostering more effective heat transfer. Results showed that the 15-degree vane angle, with a wider circumferential coverage, may result in increased wall contact, influencing heat transfer efficiency. Subsequently, at Re=6000, incremental rates of the Nusselt number ((〖Nu〗_n-〖Nu〗_s)/〖Nu〗_s %), for θ=15, 30, 45, and 60 degrees are 175.1%, 108.8%, 90.7%, and 40.3%, respectively. Also, the increment rates of Friction Factor (f_n/f_s ) for aforementioned vane angle are 38.48%, 9.26%, 4.08%, and 2.42%, respectively. In addition, for ∅_MXene=0.5 %, the Nusselt number experiences considerable increments of 22.94%, 24.17%, 24.70%, and 24.707% at Reynolds numbers of 6000, 12000, 18000, and 24000, respectively, compared to pure water, emphasizing the potential of MXene to enhance heat transfer efficiency.
Synteza i charakterystyka „zielonych” mieszanin polimerowych na bazie biopochodnego termoplastycznego poliuretanu i octanomaślanu celulozy
- Ewa Głowińska
- Joanna Smorawska
- Joanna Niesiobędzka
- Julia Grocholska
- Janusz Datta
2024 Pełny tekst Przemysł Chemiczny
Otrzymano mieszaniny polimerowe z biopochodnego termoplastycznego poliuretanu (TPU) i dostępnego handlowo octanomaślanu celulozy (CAB), stosowanego w ilości 0–20%. TPU syntezowano metodą prepolimerową z wykorzystaniem biopoliolu, glikolu 1,3-propylenowego i diizocyjanianu heksametylenu. Materiały poddano analizie pod kątem struktury chemicznej (FTIR), właściwości termicznych (TGA, DSC) i właściwości termomechanicznych (DMTA).
Synteza małocząsteczkowych pochodnych 2-pirydonu wykazujących właściwości przeciwnowotworowe oraz przeciwbakteryjne
- Małgorzata Ryczkowska
2024 Pełny tekst
Tematyka i cel badawczy niniejszej rozprawy doktorskiej dotyczy syntezy chemicznej związków heterocyklicznych z grupy 2-pirydonu wykazujących potencjał przeciwbakteryjny oraz przeciwnowotworowy. W części teoretycznej podjęto tematykę znanych fluorochinolonów oraz chinolonów wykazujących aktywność przeciwnowotworową. Dodatkowo przedstawiono nowe metody syntezy chinolonów niewymagające stosowania katalizatorów metali przejściowych oraz opublikowane na przestrzeni ostatnich 15 lat. W części badań własnych przedstawiono syntezę arylokarbamoilowych pochodnych 4-fenylo-5,6,7,8-tetrahydrochinolin-2(1H)-onu oraz badania mające na celu poznanie mechanizmu demetylowania podczas acylowania 2-metoksy-5,6,7,8-tetrahydrochinolin-8-olu izocyjanianami fenylowymi. Przedstawiono w niej również syntezę 4-fenylo-5,6,7,8-tetrahydrochinolin-2(1H)-onów modyfikowanych w pozycji 3 podstawnikami typu benzylowego. Ponadto opisano nową metodę syntezy typu „one-pot” rdzeni 4-fenylo-5,6,7,8-tetrahydrochinolin-2(1H)-onu, zbadano mechanizm powstawania trójcyklicznych pochodnych oraz przedstawiono funkcjonalizację pilicydu grupami o charakterze hydrofilowym. W części eksperymentalnej przedstawiono procedury syntezy oraz analizę spektralną wszystkich otrzymanych związków.
Synthesis and biological evaluation of novel 3,6- amide and thioamide substituted- 2,3,4,9-tetrahydro-1H-carbazoles for anti-cancer activity
- Alicja Trocka
- Anoop Kallingal
- Natalia Maciejewska
- Narajczyk Magdalena
- Anna Hromova
- Sławomir Makowiec
2024 Pełny tekst EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Herein, we report the synthesis of new compounds with demonstrated anticancer properties based on the 2,3,4,9- tetrahydro-1H-carbazole scaffold. The Fischer indolization method was used to close the heterocyclic motif. The synthesis method’s scope and limitations were thoroughly assessed through a series of experiments. Biological assays revealed that two thioamide compounds exhibited significant anticancer activity against MCF-7, HTC116, and A596 cell lines. Comprehensive in vitro profiling included evaluation of cell cytotoxicity, morphological alterations, colony formation and cell adhesion in 3D cultures, cell cycle analysis, DNA damage induction, impact on mitochondria, and apoptosis. Ex ovo studies further demonstrated these compounds’ potential to inhibit angiogenic processes. Our results indicate that the newly developed compounds activate processes leading to DNA damage and disruption of mitochondrial function.
Synthesis and characterization of MoS2-carbon based materials for enhanced energy storage applications
- Mariusz Szkoda
- Anna Ilnicka
- Konrad Trzciński
- Zuzanna Zarach
- Daria Roda
- Andrzej Nowak
2024 Scientific Reports
The article delves into the synthesis and characterization of MoS2-carbon-based materials, holding promise for applications in supercapacitors and ion batteries. The synthesis process entails the preparation of MoS2 and its carbon hybrids through exfoliation, hydrothermal treatment, and subsequent pyrolysis. Various analytical techniques were employed to comprehensively examine the structural, compositional, and morphological properties of the resulting materials. The article explores the electrochemical performance of these electrode materials in supercapacitors and ion batteries (LiB, SiB, KiB). Electrochemical measurements were conducted in aqueous electrolyte for supercapacitors and various aprotic electrolytes for ion batteries. Results highlight the impact of the synthesis process on electrochemical performance, emphasizing factors such as capacitance, rate capability, and charge/discharge cycle performance. Hydrothermally treated MoS2-carbon exhibited a specific capacitance of approximately 150 F g-1 in supercapacitors, attributed to its high surface area and efficient charge storage mechanisms. Additionally, for Li-ion battery materials without hydrothermal treatment showed impressive capacity retention of around 88% after 500 charge-discharge cycles, starting with an initial specific capacity of about 920 mAh/g. Long-term stability was demonstrated in both supercapacitors and lithium-ion batteries, with minimal capacitance degradation even after extensive charge-discharge cycles. This research underscores the potential of MoS2-based materials as effective energy storage solutions.
Synthesis and physical properties of Sm2PdGe3 in a context of RE2PdGe3 family
- Leszek Litzbarski
- Marcin Łapiński
- Tomasz Klimczuk
- Michał Winiarski
2024 JOURNAL OF SOLID STATE CHEMISTRY
In this study, we present the crystallographic and magnetic characterization of a new intermetallic compound Sm2PdGe3, which was synthetized by a two stage method employing an eutectic alloy. The investigations carried out exhibited, that Sm2PdGe3 crystallize in AlB2-type structure with lattice parameters a = 4.2189(1) Å and c = 4.1031(2) Å. This compound can be classified as a cluster-glass with a spin freezing temperature Tf = 10.5 K. Furthermore, there were carried out the analysis of the role of the rare earth (RE) elements on the structural parameters of RE2PdGe3 and draw a correlation between the RE radius and the unit cell parameters. We show that a deviation from the ideal 1:3 Pd:Ge ratio is necessary to synthesize RE2PdGe3 with smaller RE elements.
Synthesis and Properties of the Ba2PrWO6 Double Perovskite
- Damian Włodarczyk
- Mikolaj Amilusik
- Katarzyna M. Kosyl
- Maciej Chrunik
- Krystyna Ławniczak-Jabłońska
- Hanka Przybylińska
- Paulina Kosmela
- Michał Strankowski
- Lev-Ivan Bulyk
- Volodymyr Tsiumra
- Rajibul Islam
- Carmine Autieri
- Fei Xue
- Marcin Zając
- Anastasiia Lysak
- Roman Minikayev
- Michal Bockowski
- Andrzej Suchocki
2024 INORGANIC CHEMISTRY
We report details on the synthesis and properties of barium praseodymium tungstate, Ba2PrWO6, a double perovskite that has not been synthesized before. Room-temperature (RT) powder X-ray diffraction identified the most probable space group (SG) as monoclinic I2/m, but it was only slightly distorted from the cubic structure. X-ray photoelectron spectroscopy confirmed that the initial (postsynthesis) material contained praseodymium in both 3+ and 4+ charge states. The former (Pr3+) disappeared after exposure to UV light at RT. Photoluminescence studies of Pr3+ revealed that Ba2PrWO6 is an insulator with a band gap exceeding 4.93 eV. Pressure-dependent Raman spectroscopy excluded the possibility of a phase transition up to 20 GPa; however, measurements between 8 and 873 K signified that there might be a change toward the lower symmetry SG below 200 K. Electron paramagnetic resonance spectra revealed the presence of interstitial oxygen which acts as a deep electron trap.
Synthesis and Structure of Novel Hybrid Compounds Containing Phthalazin-1(2H)-imine and 4,5-Dihydro-1H-imidazole Cores and Their Sulfonyl Derivatives with Potential Biological Activities
- Łukasz Balewski
- Maria Gdaniec
- Anna Herring
- Christophe Furman
- Alina Ghinet
- Jakub Kokoszka
- Anna Ordyszewska
- Anita Kornicka
2024 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
A novel hybrid compound—2-(4,5-dihydro-1H-imidazol-2-yl)phthalazin-1(2H)-imine (5) was synthesized and converted into di-substituted sulfonamide derivatives 6a–o and phthalazine ring opening products—hydrazonomethylbenzonitriles 7a–m. The newly prepared compounds were characterized using elemental analyses, IR and NMR spectroscopy, as well as mass spectrometry. Single crystal X-ray diffraction data were collected for the representative compounds 5, 6c, 6e, 7g, and 7k. The antiproliferative activity of compound 5, sulfonyl derivatives 6a–o and benzonitriles 7a–m was evaluated on approximately sixty cell lines within nine tumor-type subpanels, including leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast. None of the tested compounds showed any activity against the cancer cell lines used. The antioxidant properties of all compounds were assessed using the DPPH, ABTS, and FRAP radical scavenging methods, as well as the β-carotene bleaching test. Antiradical tests revealed that among the investigated compounds, a moderate ABTS antiradical effect was observed for sulfonamide 6j (IC50 = 52.77 µg/mL). Benzonitrile 7i bearing two chlorine atoms on a phenyl ring system showed activity in a β-carotene bleaching test (IC50 = 86.21 µg/mL). Finally, the interaction AGE/RAGE in the presence of the selected phthalazinimines 6a, 6b, 6g, 6m, and hydrazonomethylbenzonitriles 7a, 7c–g, and 7i–k was determined by ELISA assay. A moderate inhibitory potency toward RAGE was found for hydrazonomethylbenzonitriles—7d with an electron-donating methoxy group (R = 3-CH3O-C6H4) and 7f, 7k with an electron-withdrawing substituent (7f, R = 2-Cl-C6H4; 7k, R = 4-NO2-C6H4).
Synthesis, characterization and application of cross-linked functional terpolymer through epoxy group as sorbent for extraction of cadmium from waters and foods: Multivariate optimization
- Ersen Yılmaz
- Ali Boztuğ
- Hameed Haq
- Grzegorz Boczkaj
- Nail Altunay
2024 Pełny tekst FOOD CHEMISTRY
The purpose of this study was to develop a selective sorbent for cadmium ions (Cd(II)) enrichment in orbital shaker assisted solid phase microextraction (OS-SPME) from different aqueous and food samples. A maleic anhydride-styrene-glycidyl methacrylate (MA-St-GMA) terpolymer was synthesized and characterized in detail. Experimental variables of sample preparation step were optimized using a central composite design (CCD). The final determination step was performed using flame atomic absorption spectroscopy (FAAS). The MA-St-GMA sorbent exhibited a high adsorption capacity (195.9 mg g−1) for the Cd(II) ion. The developed method under optimal conditions provides satisfactory performance and a significant improvement compared to other protocols available in the literature. The linear range and detection limit of the method is 0.1–130 ng mL−1 and 0.03 ng mL−1, respectively. The robustness, intraday/interday precision, selectivity, and accuracy of the method were investigated. To further validate the method, a dedicated series of analysis was performed using certified reference materials (CRMs). This part of the study confirmed the applicability of the method for routine analysis. The OS-SPME-FAAS method was validated using water and food samples. Relative standard deviations and recovery for real-world samples were in ranges 1.7–2.2 % and 95.5–98.5 %, respectively. As a result, the MA-St-GMA sorbent showed that it could quantitatively extract Cd(II) ions from aqueous solution.
Synthesis of Trehalose by the Erythritol-Producing Yeast Yarrowia lipolytica Co-Displaying Maltooligosyltrehalose Synthase and Maltooligosyltrehalose Trehalohydrolase
- Shuo Xu
- Yawen Zou
- Liyun Ji
- Muhammad Bilal
- Hairong Cheng
2024 ACS Sustainable Chemistry & Engineering
Industrial trehalose production faces economic challenges with costly enzyme preparations, prompting the exploration of eco-friendly alternatives. Here, we established a coupled functional sugar production line leveraging erythritolproducing cells as an innovative enzyme preparation for trehalose synthesis. The erythritol-producing Yarrowia lipolytica was modified to express a fusion protein consisting of maltooligosyltrehalose synthase and maltooligosyltrehalose trehalohydrolase from Sulfolobus solfataricus ATCC35092. The engineered strain YlxsT08 was used for the simultaneous synthesis of erythritol and the fusion protein. The yield, production, and productivity of erythritol reached 0.55 g/g of glucose, 166.18 g/L, and 1.98 g/(L· h), respectively, in a 5 L bioreactor. The recycled cells (49.77 U/ mg of DCW) exhibited a high catalytic efficiency in the bioconversion of maltodextrin to generate trehalose. The yield, production, and productivity of trehalose reached 0.67 g/g maltodextrin, 134.40 g/L, and 5.60 g/(L·h), respectively, in a 5 L bioreactor. The byproducts were removed by biological purification, and the resulting cells were recycled as catalysts for at least the next 5 rounds of trehalose production. Our novel strategy provides an ecologically sustainable and economically feasible alternative to enzyme combinations in trehalose production, offering a cost-effective and eco-friendly enzyme manufacturing method.