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Chitin and derivative chitosan-based structures — Preparation strategies aided by deep eutectic solvents: A review
- Mohammad Khajavian
- Vahid Vatanpour
- Roberto Castro-Muñoz
- Grzegorz Boczkaj
2022 Pełny tekst CARBOHYDRATE POLYMERS
The high molecular weight of chitin, as a biopolymer, challenges its extraction due to its insolubility in the solvents. Also, chitosan, as the N-deacetylated form of chitin, can be employed as a primary material for different industries. The low mechanical stability and poor plasticity of chitosan films, as a result of incompatible interaction between chitosan and the used solvent, have limited its industrialization. Deep eutectic solvents (DESs), as novel solvents, can solve the extraction difficulties of chitin, and the low mechanical stability and weak plasticity of chitosan films. Also, DESs can be considered for the different chitosan and chitin productions, including chitin nanocrystal and nanofiber, N,N,N-trimethyl-chitosan, chitosan-based imprinted structures, and DES-chitosan-based beads and monoliths. This review aims to focus on the preparation and characterization (chemistry and morphology) of DES-chitin-based and DES-chitosan-based structures to understand the influence of the incorporation of DESs into the chitin and chitosan structure.
Chitosan-based inks for 3D printing and bioprinting
- Mohsen Taghizadeh
- Ali Taghizadeh
- Mohsen Khodadadi Yazdi
- Payam Zarrintaj
- Florian J. Stadler
- Joshua D. Ramsey
- Sajjad Habibzadeh
- Ghasem Naderi
- Mohammad Saeb
- Masoud Mozafari
- Ulrich Schubert
2022 GREEN CHEMISTRY
The advent of 3D-printing/additive manufacturing in biomedical engineering field has introduced great potential for the preparation of 3D structures that can mimic native tissues. This technology has accelerated the progress in numerous areas of regenerative medicine, especially led to a big wave of biomimetic functional scaffold developments for tissue engineering demands. In recent years, the introduction of smart bio-inks has created growing efforts to facilitate the preparation of complex and homogeneous living-cell-containing 3D constructs. In the past decade, a considerable body of literature has been created on identifying an ideal bioinspired-ink with excellent printability, cell viability, bioactivity, and mechanical properties. This state-of-the-art review article briefly outlines 3D-printing/bioprinting techniques applied for chitosan-based bio-inks, their resources, crosslinking methods, characteristics, reasons for their superiority over other bio-inks, and challenges of commercialization; this is followed by a comprehensive description of the full potential and the key indicators of success in terms of 3D bio-printing of such bio-inks as platforms for tissue regeneration, advanced biosensors, drug delivery, and wastewater treatment. Next, the restrictions and challenges of chitosan bio-inks are highlighted. In this work, we also discussed about developing a coherent research strategy based on combination of microfluidics-based lab-on-a-chip (organ-on-a-chip) platforms with 3D-bioprinting which enables designing of self-healing scaffolds. And finally, the potential of smart inks based on chitosan for 4D bioprinting of more detailed and practical engineered tissues and artificial organs is reviewed.
Chitosan/poly(4-vinylpyridine) coatings formed on AgNPs-decorated titanium
- Łukasz Pawłowski
- Michał Bartmański
- Aleksandra Mielewczyk-Gryń
- Andrzej Zieliński
2022 Pełny tekst MATERIALS LETTERS
Electrophoretic deposition (EPD) of chitosan/poly(4-vinylpyridine) (chit/P4VP) coatings on titanium substrates previously decorated with silver nanoparticles (AgNPs) was performed at different content of P4VP in the suspension and different voltage values. The results revealed that the composite coatings were formed, well-adjacent to the titanium substrate, of suitable roughness, hydrophilicity, and corrosion resistance. The voltage value and P4VP content had complex effects on coating properties, due to the effects of process parameters on microstructure and adhesion. The best coatings of both chitosan and P4VP were formed at 10 V at 0.1% (w/w) during a one-minute deposition. These pH-sensitive antibacterial coatings may, based on the present results, be recommended for surface modification of titanium implants.
Chlorine-free extraction and structural characterization of cellulose nanofibers from waste husk of millet (Pennisetum glaucum)
- C.d. Midhun Dominic
- Vandita Raj
- K.v. Neenu
- P.M. Sabura Begum
- Krzysztof Formela
- Mohammad Saeb
- Deepak D. Prabhu
- P. Poornima Vijayan
- T.g. Ajithkumar
- Jyotishkumar Parameswaranpillai
2022 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
This study aims to extract cellulose nanofibers (CNFs) from a sustainable source, i.e. millet husk, which is an agro-waste worthy of consideration. Pre-treatments such as mercerisation, steam explosion, and peroxide bleaching (chlorine-free) were applied for the removal of non-cellulosic components. The bleached millet husk pulp was subjected to acid hydrolysis (5% oxalic acid) followed by homogenization to extract CNFs. The extracted CNFs were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Dynamic Light Scattering (DLS), Energy Dispersive X-ray Spectroscopy (EDX), Thermogravimetry (TG and DTG), Differential scanning calorimetry (DSC), and Solid state 13C nuclear magnetic resonance spectroscopy (solid state 13C NMR). The isolated CNFs show a typical cellulose type-I structure with a diameter of 10-12 nm and a crystallinity index of 58.5%. The appearance of the specific peak at 89.31 ppm in the solid state 13C NMR spectra validates the existence of the type-I cellulose phase in the prepared CNFs. The prepared CNFs had a maximum degradation temperature (Tmax) of 341 °C, that was 31 °C greater than raw millet husk (RMH). The outcome of the study implies that the nanofibers are prominent alternatives for synthetic fibers for assorted potential applications, especially in manufacturing green composites.
Choosing the Right Cybersecurity Solution: A Review of Selection and Evaluation Criteria
- Rafał Leszczyna
2022 Pełny tekst
Information technologies evolve continuously reaching pioneering areas that bring in new cybersecurity challenges. Security engineering needs to keep pace with the advancing cyberthreats by providing innovative solutions. At the same time, the foundations that include security and risk assessment methodologies should remain stable. Experts are oﬀered with an extensive portfolio of solutions and an informed choice of a particular one becomes problematic. Transparent criteria are the instrument that answers this issue by laying the ground for evidence-based justiﬁcations. Within the framework of systematic literature analysis, this study reviews the criteria proposed in the relevant literature. Based on the outcome, a consolidated set of criteria that should help in choosing a cybersecurity solution is proposed. Ethical questions posed by certain cybersecurity assessment activities are discussed. Consequently, new criteria related to the ethical application of a solution are introduced in the consolidated set.
Clean energy in the European Union: Transition or evolution?
- Radosław Ślosarski
2022 Pełny tekst Energy & Environment
In this paper, we analyse two phenomena. First, the relationship between greenhouse gases emission and effectiveness of the European Union energy policies and second the transition from the fossil fuels to renewable energy sources. We run two-step data analysis concerning 25 European Union member states in the period from 1990 to 2018. We use information on greenhouse gases emission, introduction of new energy policies, source of energy supplied and merge it with macroeconomic data on the countries’ structural characteristics. We assess their long-run relationship and direction of causality using panel cointegration tests and dynamic panel data models. We identify a statistically significant effect of energy supply source, energy policy introduction and greenhouse gases emission. However, we were not able to confirm that European Union energy sector is in transition. Thus, obtained results confirm that the EU energy policies are effective however not sufficient enough in decreasing use of fossil fuels to call it a transition towards renewables.
Cleaner energy for sustainable future using hybrid photovoltaics-thermoelectric generators system under non-static conditions using machine learning based control technique
- Adeel Mirza
- Paweł Szczepankowski
- Jarosław Łuszcz
2022 Sustainable Energy Technologies and Assessments
In addition to the load demand, the temperature difference between the hot and cold sides of the thermoelectric generator (TEG) module determines the output power for thermoelectric generator systems. Maximum power point tracking (MPPT) control is needed to track the optimal global power point as operating conditions change. The growing use of electricity and the decline in the use of fossil fuels have sparked interest in photovoltaic-TEG system utilization in the energy sector. Thermoelectric generation systems are meant to recover waste heat as a green energy supply. Concentrated solar can overcome the drawbacks of inefficient power generation. The feasibility of employing a machine learning and metaheuristic-based control strategy to yield maximum power from a hybrid photovoltaic and thermoelectric generator system under various operating situations is examined in this study. The output of both TEG and PV modules is affected by the environment; PV panels create heat as a result of shade and wind speed. Maximum energy harvesting of PV-TEG under non-uniform temperature settings is proposed in this paper using a feed-forward neural network (FFNN) trained by a squirrel search optimization (SQS). TEG systems have several local maxima due to this non-uniform state. MPPT algorithms based on gradients are unlikely to discover actual GMPP in the majority of cases. The unique SQSFFNN is evaluated under non-uniform temperature distribution and variable load and temperature circumstances as a possible answer to this non-linear issue. Certain advances are made in this study by addressing concerns of global maximum power point tracking with non-uniform temperature distribution, low efficiency, higher settling and tracking time, and oscillations. Particle swarm optimization, Cuckoo search optimization (CSA), CSA-FFNN, and grey wolf optimization algorithms are compared to the outcomes. Four experiments are carried out under various meteorological situations. Experiments and MATLAB/SIMULINK are used to validate and prove the results. The experimental results, comparisons with existing techniques, and statistical data show that the suggested SQDFFNN technique achieves a greater performance, distinguishing PV-TEG as a cleaner source of electrical power generation.
Clickable polysaccharides for biomedical applications: A comprehensive review
- Mohsen Khodadadi Yazdi
- S. Mohammad Sajadi
- Farzad Seidi
- Navid Rabiee
- Yousef Fatahi
- Mohammad Rabiee
- C.D. Midhun Dominic
- Payam Zarrintaj
- Krzysztof Formela
- Mohammad Saeb
- Sidi A. Bencherif
2022 Pełny tekst PROGRESS IN POLYMER SCIENCE
Recent advances in materials science and engineering highlight the importance of designing sophisticated biomaterials with well-defined architectures and tunable properties for emerging biomedical applications. Click chemistry, a powerful method allowing specific and controllable bioorthogonal reactions, has revolutionized our ability to make complex molecular structures with a high level of specificity, selectivity, and yield under mild conditions. These features combined with minimal byproduct formation have enabled the design of a wide range of macromolecular architectures from quick and versatile click reactions. Furthermore, copper-free click chemistry has resulted in a change of paradigm, allowing researchers to perform highly selective chemical reactions in biological environments to further understand the structure and function of cells. In living systems, introducing clickable groups into biomolecules such as polysaccharides (PSA) has been explored as a general approach to conduct medicinal chemistry and potentially help solve healthcare needs. De novo biosynthetic pathways for chemical synthesis have also been exploited and optimized to perform PSA-based bioconjugation inside living cells without interfering with their native processes or functions. This strategy obviates the need for laborious and costly chemical reactions which normally require extensive and time-consuming purification steps. Using these approaches, various PSA-based macromolecules have been manufactured as building blocks for the design of novel biomaterials. Clickable PSA provide a powerful and versatile toolbox for biomaterials scientists and will increasingly play a crucial role in the biomedical field. Specifically, bioclick reactions with PSA have been leveraged for the design of advanced drug delivery systems and minimally invasive injectable hydrogels. In this review article, we have outlined the key aspects and breadth of PSA-derived bioclick reactions as a powerful and versatile toolbox to design advanced polymeric biomaterials for biomedical applications such as molecular imaging, drug delivery, and tissue engineering. Additionally, we have also discussed the past achievements, present developments, and recent trends of clickable PSA-based biomaterials such as three dimensional printing, as well as their challenges, clinical translatability, and future perspectives.
Clinical anatomy of the spatial structure of the right ventricular outflow trac
- Agata Kaczyńska
- Adam Kosiński
- Katarzyna Bobkowska
- Miłosz Zajączkowski
- Rafał Kamiński
- Grzegorz Piwko
- Marta Gleinert-Rożek
- Tomasz Gos
- Karol Karnecki
- Dariusz Kozłowski
2022 Pełny tekst Advances in Clinical and Experimental Medicine
Background. The right ventricular outflow tract (RVOT) is located above the supraventricular crest and reaches the level of the pulmonary valve. Detailed knowledge of the RVOT spatial structure and its morphology is extremely important for cardiac invasive therapeutic procedures. Objectives. To examine the spatial structure of the RVOT using virtual models of the right ventricle (RV) interior obtained post mortem. Material and Methods. The study was carried out using 40 adult hearts from both sexes fixed in formalin. Donors had a negative history of cardiovascular diseases. Silicone models of the interior of the RV were made and then subjected to a digital modelling procedure using the photogrammetry technique. For each 3D model of the RV, the RVOT was extracted and measurements were performed. Results. Statistical analysis demonstrated that the dimensions of the transverse (p < 0.001) and sagittal (p = 0.002) axis at the level of the upper and lower border of the RVOT differed significantly. There was also a significant difference between the right and left height of the RVOT (p = 0.009). A clear correlation was found between the volume of the RVOT and the volume of the entire RV (r = 0.718, p < 0.001). Conclusion. The obtained 3D models of the RVOT can help standardize the data related to RVOT architecture. Furthermore, they can extend knowledge about the RVOT in the field of cardiology and improve the procedures in cardiac surgery.
Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
- Andrzej Kwiatkowski
- Sebastian Borys
- Katarzyna Sikorska
- Katarzyna Drozdowska
- Janusz Smulko
2022 Pełny tekst Scientific Reports
The COVID‑19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS‑CoV‑2 detection. Numerous tests can be used at home within 15 min or so but of with lower accuracy than PCR. There is still a need for point‑of‑care tests available for mass daily screening of large crowds in airports, schools, and stadiums. The same problem exists with fast and continuous monitoring of patients during their medical treatment. The rapid methods can use exhaled breath analysis which is non‑invasive and delivers the result quite fast. Electronic nose can detect a cocktail of volatile organic com‑pounds (VOCs) induced by virus infection and disturbed metabolism in the human body. In our exploratory studies, we present the results of COVID‑19 detection in a local hospital by applying the developed electronic setup utilising commercial VOC gas sensors. We consider the technical problems noticed during the reported studies and affecting the detection results. We believe that our studies help to advance the proposed technique to limit the spread of COVID‑19 and similar viral infections.
Cluster organization as a form of non-technological innovation
- Anna Lis
- Arkadiusz Michał Kowalski
2022
The paper aims to investigate the relationships that cluster enterprises develop with their environment through participation in cluster organization (CO). The authors report the findings from a qualitative study carried out in the Lubusz Metal Cluster. The main research strategy is case study. An in-depth individual interview was used to collect the data, and qualitative content analysis and coding for its analysis. The study has shown that cluster enterprises develop relationships with various groups of stakeholders, which include other enterprises, R&D institutions, educational institutions, business environment institutions, and public authorities. Building relationships with each of these groups of stakeholders is based on different set of goals; it also leads to obtaining a different pool of value creating benefits, which are jointly formed by all groups of stakeholders. The first-order benefits result directly from the cluster cooperation, while the second-order benefits consist in gradual integration: first in the social dimension, then in the process and organizational dimension, and ending with the integration of the entire industry. The research goes beyond the state-of-the-art knowledge in the concept of industrial clusters, revealing CO as an example of non-technological innovation, which applies in particular management of external relations with other companies or public institutions.
Cmentarze w przestrzeni polskich miast
- Anna Myślińska
2022 Pełny tekst
Przedmiotem badań jest przedstawienie cmentarzy na terenach polskich miast: Gdańska, Krakowa, Lublina, Warszawy i Wrocławia. Na potrzeby pracy przeanalizowano położenie cmentarzy względem współczesnej i historycznej tkanki miejskiej a także względem innych nekropolii, dzięki czemu zidentyfikowano zjawisko występowania zespołów cmentarzy miejskich. Zbadano także zagadnienie likwidacji cmentarzy miejskich i odniesiono je do współczesnych problemów związanych z wpływem nekropolii na środowisko. Wyczerpujący opis wymienionych wyżej zagadnień powstał w oparciu o literaturę tematu, badania źródeł kartograficznych oraz studia obejmujące: historię cmentarzy w wybranych miastach, zestawienie zarówno istniejących jak i nieistniejących cmentarzy we współczesnych granicach administracyjnych tych miast oraz analizę współczesnych funkcji terenów na obszarach nieistniejących już nekropolii. Zebraną wiedzę wykorzystano w celu stworzenia wytycznych dla projektowania nowoczesnych nekropolii miejskich.
c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
- Monika Pawłowska
- Jolanta Kulesza
- Ewa Augustin
2022 Pełny tekst INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Unsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer cells, they can be used as therapeutic targets. Herein, we investigate whether UAs can affect the expression and protein level of c-Myc and K-Ras in HCT116 and H460 cancer cells, and if so, what are the consequences for the UAs-induced cellular response. UAs did not affect K-Ras, but they strongly influenced the expression and translation of the c-Myc protein, and in H460 cells, they caused its full inhibition. UAs treatment resulted in apoptosis, as confirmed by the morphological changes, the presence of sub-G1 population and active caspase-3, cleaved PARP, annexin-V/PI staining and a decrease in mitochondrial potential. Importantly, apoptosis was induced earlier and to a greater extent in H460 compared to HCT116 cells. Moreover, accelerated senescence occurred only in H460 cells. In conclusion, the strong inhibition of c-Myc by UAs in H460 cells may participate in the final cellular response (apoptosis, senescence).
Co stymuluje rozwój współczesnej teleinformatyki i jakie są istotne kierunki tego rozwoju?
- Józef Woźniak
- Jordi Mongay Batalla
- Andrzej Bęben
- Marek Natkaniec
- Zbigniew Piotrowski
- Krzysztof Szczypiorski
2022 Pełny tekst Przegląd Telekomunikacyjny + Wiadomości Telekomunikacyjne
Corocznie dokonuje się oceny stanu sztuki i tendencji w rozwoju światowej telekomunikacji i (tele)informatyki przywołując „mierzalne” i „niemierzalne” zmiany. W artykule przedstawiono charakter tych zmian oraz wskazano wyzwania badawcze i wdrożeniowe istotne dla rozwoju tych dyscyplin. Zaprezentowano i scharakteryzowano ewolucję infrastruktury sieciowej prowadzącą do sieci programowalnych SDN (Software Defined Network) oraz wykorzystania technik wirtualizacji funkcji sieciowych NFV (Network Function Virtualisation), prezentując też kierunki rozwoju nowych aplikacji i usług oferowanych z wykorzystaniem zasobów chmur obliczeniowych oraz technik przetwarzania danych na brzegu sieci (Edge/Fog computing). Szczególną uwagę poświęcono systemom i sieciom piątej generacji 5G, adresującym problemy różnych grup użytkowników i odpowiadającym na bardzo zróżnicowane wymagania jakościowe, energetyczne czy zasięgowe. Zaprezentowano też podstawowe obszary zastosowań Internetu Rzeczy oraz Wszechrzeczy IoT/IoE, prezentując w tym kontekście potrzeby i korzyści związane z użyciem technik uczenia maszynowego oraz sztucznej inteligencji do zapewniania efektywniejszego wykorzystania zasobów sieci IoT, czy też istotnego komponentu sieci 5G jakim jest Przemysł 4.0. Dokonano też krótkiej analizy zagrożeń oraz zasad wdrażania cyberbezpieczeństwa i zapewniania bezpieczeństwa informacji w systemach i sieciach teleinformatycznych. SŁOWA KLUCZOWE: Technologie ICT, trendy w rozwoju, kierunki zmian, charakterystyka, separacja oprogramowania i sprzętu: VFN, SDN, sieci 5G, IoT/E, aplikacje chmurowe, obliczenia na brzegu sieci: Edge/Fog computing, cyberbezpieczeństwo: zagrożenia i metody przeciwdziałania
Cognitive neuroscience: Theta network oscillations coordinate development of episodic memory
- Michał Kucewicz
2022 Pełny tekst CURRENT BIOLOGY
Our ability to remember life events matures through childhood and adolescence. A new study has revealed how theta oscillations between two anatomical brain regions supporting memory and executive functions are synchronized and develop across age through functional and structural connectivity.
Cold recycled mixtures for binder courses - laboratory evaluation of mechanical properties
- Bohdan Dołżycki
- Mariusz Jaczewski
- Cezary Szydłowski
2022 Pełny tekst
Cold recycled mixtures composed with cement and bituminous emulsion are nowadays commonly used material for base layer. Typical pavement with cold recycled mixtures usually consists of two asphalt courses (wearing and binding course) constructed over cold recycled base. Therefore the next step in cold recycling is possibility of design of binding courses with recycled materials, but with potential to obtain high quality mixtures similar to commonly used asphalt concretes. In this case, typical new pavement structure would be designed as two cold recycled mixtures (for base and binding course) covered by wearing course. This publication presents both basic and advanced laboratory results for cold recycled binding course. Cold recycle binding course is characterized by more strict requirements for base material gradation and more strict ranges for possible properties. Also the composition of binding agents is selected to be as similar as for typical asphalt concretes. In laboratory following test were performed: volumetric properties, resistance to water and frost action, viscoelastic properties (dynamic modulus, phase angles) and resistance to fracture in SCB test. For comparison, the same test were performed for asphalt concrete for binder course and for selected test also for cement bound mixtures. Obtained results indicate that cold recycled mixtures for binder course are located between typical asphalt concretes and cement bound mixtures, characterizing by both high bearing capacity and sufficient viscoelastic properties. In the case of resistance to water and frost, cold recycled mixtures are characterized by ratio between 75-85%. Cold recycled mixtures showed good fracture resistance results in SCB test in comparison to other tested mixtures. Laboratory stage of research confirmed very good properties of cold recycled binding course and open possibility for further steps to construct and evaluate the designed mixtures on real life conditions on trial section in real environmental conditions.
Collective creativity in management science
- Damian Ciachorowski
- Anna Lis
2022 Pełny tekst Engineering Management in Production and Services
Purpose: The purpose of this paper is to establish the current state of knowledge on collective creativity in management science on the basis of a systematic literature review. Methodology: A systematic review was performed based on the three-step SPL procedure proposed by Tranfield et al. (2003). Two databases (Scopus and Web of Science) were searched electronically up until March 2022. Based on the secondary data a literature analysis and content analysis were carried out. Results: As a result of the systematic literature review procedure, a total of eighteen studies met the inclusion criteria. The descriptive and thematic analysis conducted allowed to establish the state of knowledge in the analyzed area and to identify the main thematic areas along with the directions of future research. The theoretical contribution: The proposed research is the first to conduct a systematic literature review in collective creativity in management science. The main contribution of this paper is its exclusive focus on the analysis of existing research in the field of collective creativity, additionally limited to management science. Based on SLR, it was possible to determine that research in the analyzed area is still at a fairly early stage. Although the existing literature sheds some light on collective creativity, studies investigating the great aspects of teamwork focused on problem solving are needed.
ColorNephroNet: Kidney tumor malignancy prediction using medical image colorization
- Aleksander Obuchowski
- Barbara Klaudel
- Roman Karski
- Bartosz Rydziński
- Mateusz Glembin
- Paweł Syty
- Patryk Jasik
2022 Pełny tekst Proceedings of FLAIRS-35
Renal tumor malignancy classification is one of the crucial tasks in urology, being a primary factor included in the decision of whether to perform kidney removal surgery (nephrectomy) or not. Currently, tumor malignancy prediction is determined by the radiological diagnosis based on computed tomography (CT) images. However, it is estimated that up to 16% of nephrectomies could have been avoided because the tumor that had been diagnosed as malignant, was found to be benign in the postoperative histopathological examination. The excess of false-positive diagnoses results in unnecessarily performed nephrectomies that carry the risk of periprocedural complications. In this paper, we present a machine-aided diagnosis system that predicts the tumor malignancy based on a CT image. The prediction is performed after radiological diagnosis and is used to capture false-positive diagnoses. Our solution is able to achieve a 0.84 F1-score in this task. We also propose a novel approach to knowledge transfer in the medical domain in terms of colorization based pre-processing that is able to increase the F1-score by up to 1.8pp.
Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
- Marta Świtalska
- Beata Filip‐Psurska
- Magdalena Milczarek
- Mateusz Psurski
- Adrianna Moszyńska
- Aleksandra Dąbrowska
- Małgorzata Gawrońska
- Karol Krzymiński
- Maciej Bagiński
- Rafał Bartoszewski
- Joanna Wietrzyk
2022 Pełny tekst JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
The acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study was to analyse the effects of the combined treatment of C-1305 and PTX in vivo. In addition, considering the results of previous genomic analyses, par-ticular attention was given to the effects of this treatment on tumour angiogenesis. Treatment with C-1305 revealed antitumor effect in A549 lung cancer cells, and com-bined treatment with PTX showed tendency to anticancer activity in HCT116 colon cancer xenografts. It also improved tumour blood perfusion in both tumour models. The plasma level of CCL2 was increased and that of PDGF was decreased after com-bined treatment with C-1305 and PTX. The experimental results showed that the levels of FGF1, TGF-β and Ang-4 decreased, whereas the levels of ERK1/2 and Akt phosphorylation increased in HCT116 tumour tissue following combined treatment with both drugs. The results of in vitro capillary- like structure formation assay dem-onstrated the inhibiting effect of C-1305 on this process. Although previous in vitro and in vivo studies suggested a positive effect of C-1305 on cancer cells, combined treatment of HCT116 human colon and A549 lung cancer cells with both PTX and C- 1305 in vivo showed that the antitumor activity was restricted and associated with the modulation of tumour angiogenesis.
Combined chemoresistive and in situ FTIR spectroscopy study of nanoporous NiO films for light-activated nitrogen dioxide and acetone gas sensing
- Katarzyna Drozdowska
- Tesfalem Welearegay
- Lars Österlund
- Janusz Smulko
2022 Pełny tekst SENSORS AND ACTUATORS B-CHEMICAL
The chemoresistive sensor response of nanoporous NiO films prepared by advanced gas deposition was investigated by combined resistivity and in situ FTIR spectroscopy, with and without simultaneous light illumination, to detect NO2 and acetone gases. The sensitivity towards NO2 increased dramatically under UV irradiation employing 275 nm light. Improved sensitivity was observed at an elevated temperature of 150 °C. In situ FTIR measurements were performed to record the transient gas adsorption/desorption processes. The sustained sensitivity and repeatability for NO2 sensing could be attributed to reversible surface-nitro and nitrate species formation, which are stable on the surface at relative humidity up to 40%. In contrast, acetone sensing results in irreversible decomposition and accumulation of reaction products on the NiO sensor surface, covering the surface and limiting gas sensing. Implications of the study for improved and sustained NiO gas sensor properties in gas mixtures are discussed.