2022 - Repozytorium publikacji - Politechnika Gdańska

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Featured based CAVE software factory
- Jacek Lebiedź
- Bogdan Wiszniewski
2022 Pełny tekst
In the paper we convey the lessons learned along the path we have gone through several years since establishing a room-sized CAVE installation at our university, from craft manufacturing and ad-hoc software reuse of VR software products to the robust feature driven software product line (SPL) implementing the Product Line Engineering (PLE) factory paradigm. With that we can serve all our departments and other entities from the region by rapidly instantiating different VR products based on a standard set of core assets and driven by a set of common features of VR applications destined to be deployed in the same target CAVE system – with the minimal budget and time to market requirements. A comprehensive survey of the most representative CAVE applications created in Gdansk Tech Immersive 3D Visualization Lab (I3DVL) according to PLE paradigm presented in the paper provides evidence supporting this claim.
Features of irregularity in examples of Polish multi-family architecture constructed in 2011–2021 and nominated for the Mies van der Rohe award
- Michał Malewczyk
- Piotr Czyż
2022 Pełny tekst Czasopismo Techniczne
This article is devoted to the analysis of contemporary Polish multi-family architecture in the context of aesthetic irregularity. The research was limited to constructions from 2011–2021 and nominated for the Mies van der Rohe award as the objects with the greatest potential impact on shaping further trends. In their research, the authors focused on searching for the features of irregularities, which, in their opinion, have become a distinguishing feature of contemporary architectural aesthetics. The analyses in this study refer to three planes of the aesthetic dimension of architecture, namely the form, facade composition and material.
Featuring Semitransparent p–i–n Perovskite Solar Cells for High-Efficiency Four-Terminal/Silicon Tandem Solar Cells
- Pei-Huan Lee
- Ting-Tzu Wu
- Chia-Feng Li
- Damian Głowienka
- Yu-Xuan Huang
- Shih-Han Huang
- Yu-Ching Huang
- Wei-Fang Su
2022 Pełny tekst Solar RRL
Two issues need to be resolved when fabricating p–i–n semitransparent perovskite solar cells (ST-PVSCs) for four-terminal (4 T) perovskite/silicon tandem solar cells: 1) damage to the underlying absorber (MAPbI3), electron transporting layer ([6,6]-phenyl-C61-butyric acid methyl ester, PCBM), and work function (WF) modifier (polyethylenimine, PEI), resulting from the harsh sputtering conditions for the transparent electrodes (TEs) and 2) low average near-infrared transmittance (ANT) of TEs. Herein, a unique SnO2 layer to protect the MAPbI3 and PCBM layers is developed and functions as a WF modifier for a new TE (cerium-doped indium oxide, ICO), which exhibits an excellent ANT of 86.7% in the range of 800−1200 nm. Moreover, a MAPbI3-based p–i–n ST-PVSC is prepared, achieving an excellent power conversion efficiency (PCE) of 17.23%. When it is placed over the Si solar cell, a 4 T tandem solar cell with a PCE of 26.14% is obtained.
FEM and experimental investigations of concrete temperature field in the massive stemwall of the bridge abutment
- Aleksandra Kuryłowicz-Cudowska
- Krzysztof Wilde
2022 Pełny tekst CONSTRUCTION AND BUILDING MATERIALS
The paper deals with the prediction of early-age concrete temperature of cast-in-place stemwall of the bridge abutment. The considered object is an arch bridge located in Gda´nsk. In the case of massive structures, it is particularly important to not exceed the temperature difference between the core and the concrete surface. Too high temperature gradient generates an increase in thermal stresses, what could be the reason of exceeding the tensile strength and as a consequence cracking occurrence. Therefore, the numerical simulations of concrete hardening were conducted using own codes of finite difference and finite elements method. Based on numerical results the project of monitoring system was developed. The concrete temperature of stemwall was registered during 12 days by using fifteen 1-wire digital sensors. The recorded thermal data are highly consistent with FE results, which confirms the accuracy of the finite element model. The conducted calculations and in-situ measurements allowed to determine guidelines for proper curing of massive abutment’s wall.
Femtosecond Er-doped fiber laser source tunable from 872 to 1075 nm for two-photon vision studies in humans
- Dorota Stachowiak
- Marcin Marzejon
- Jakub Bogusławski
- Zbigniew Łaszczych
- Katarzyna Komar
- Maciej Wojtkowski
- Grzegorz Soboń
2022 Pełny tekst Biomedical Optics Express
We report the development of a widely-tunable femtosecond fiber laser system and its application for two-photon vision studies. The source is based on an Er-doped fiber laser with spectral shift up to 2150 nm, followed by a second harmonic generation module to generate a frequency-doubled beam tunable from 872 to 1075 nm. The source delivers sub-230 fs pulses with nearly-constant duration over the entire tuning range, with output powers between 0.68–1.24 mW, which corresponds to a pulse energy of 13.2–24.1 pJ. Such pulse energy is sufficient for employing a system for measurements of two-photon scotopic spectral sensitivity of two-photon vision in humans. The laser parameters allow for very efficient and safe two-photon stimulation of the human visual system, as proved by a good separation between one- and two-photon thresholds for wavelengths below 950 nm, which we have confirmed for 3 healthy subjects.
Ferromagnetism in Pr-rich binary Pr7Ru3 intermetallic compound
- Szymon Królak
- Hanna Świątek
- Karolina Górnicka
- Michał Winiarski
- Weiwei Xie
- Robert J. Cava
- Tomasz Klimczuk
2022 Pełny tekst JOURNAL OF ALLOYS AND COMPOUNDS
We present the synthesis and experimental characterization of the binary intermetallic compound Pr7Ru3. The polycrystalline sample was prepared by arc melting pure Pr and Ru, followed by homogenization at 500 °C and 600 °C for 48 and 89 h, respectively. Powder x-ray diffraction confirms that Pr7Ru3 crystallizes in an orthorhombic crystal structure (Pnma, space group no. 62) with the lattice parameters: a = 7.3606(7) Å, b = 23.120(1) Å and c = 6.5959(5) Å. Magnetization, resistivity, and heat capacity measurements reveal a ferromagnetic transition in Pr7Ru3 with the Curie temperature TC ∼ 24.5 K. The bulk transition is confirmed by a large λ-shape anomaly observed in the specific heat measurement. The magnetic susceptibility above the transition obeys the modified Curie-Weiss law with a positive Curie-Weiss temperature ϴCW = 30(1) K and an effective magnetic moment of 3.39(1) μB/Pr. Resistivity data for Pr7Ru3 reveals metallic-like behavior with a clear anomaly at the transition temperature which is smeared by an applied magnetic field. We also synthesized high-quality nonmagnetic analog La7Ru3 for which superconducting transition is observed with Tc = 1.95 K, in agreement with the literature.
Field Evaluation of High Modulus Asphalt Concrete Resistance to Low-Temperature Cracking
- Marek Pszczoła
- Dawid Ryś
- Mariusz Jaczewski
2022 Pełny tekst Materials
High-modulus asphalt concrete has numerous advantages in comparison to conventional asphalt concrete, including increased resistance to permanent deformations and increased pavement fatigue life. However, previous studies have shown that the construction of road pavements with High Modulus Asphalt Concrete (HMAC) may significantly increase the risk of low-temperature cracking. Those observations were the motivation for the research presented in this paper. Four test sections with HMAC used in base and binder courses were evaluated in the study. Field investigations of the number of low-temperature cracks were performed over several years. It was established that the number of new low-temperature cracks is susceptible to many random factors, and the statistical term “reversion to the mean” should be considered. A new factor named Increase in Cracking Index was developed to analyze the resistance of pavement to low-temperature cracking. For all the considered field sections, samples were cut from each asphalt layer, and Thermal Stress Restrained Specimen Tests were performed in the laboratory. Correlations of temperature at failure and cryogenic stresses with the cracking intensity observed in the field were analyzed. The paper provides practical suggestions for pavement designers. When the use of high modulus asphalt concrete is planned for binder course and asphalt base, which may result in lower resistance to low-temperature cracking of pavement than in the case of conventional asphalt concrete, it is advisable to apply a wearing course with improved resistance to low-temperature cracking. Such an approach may compensate for the adverse effects of usage of high modulus asphalt concrete.
Finite-window RLS algorithms
- Lu Shen
- Yuriy Zakharov
- Maciej Niedźwiecki
- Artur Gańcza
2022 Pełny tekst SIGNAL PROCESSING
Two recursive least-squares (RLS) adaptive filtering algorithms are most often used in practice, the exponential and sliding (rectangular) window RLS algorithms. This popularity is mainly due to existence of low-complexity versions of these algorithms. However, these two windows are not always the best choice for identification of fast time-varying systems, when the identification performance is most important. In this paper, we show how RLS algorithms with arbitrary finite-length windows can be implemented at a complexity comparable to that of exponential and sliding window RLS algorithms. Then, as an example, we show an improvement in the performance when using the proposed finite-window RLS algorithm with the Hanning window for identification of fast time-varying systems.
Fire Protection and Materials Flammability Control by Artificial Intelligence
- Henri Vahabi
- Mohammad Naser Eldine
- Mohammad Saeb
2022 FIRE TECHNOLOGY
Fire safety has become a major challenge of materials developers because of the massive production of organic materials, often combustibles, and their use for different purposes. In this sense, fire safety is critically considered in the development of engineering materials [1, 2]. The multiplicity of parameters contributing to the development of formulation of flame-retardant materials from one side and the sustainability concerns from the other side make the innovations cumbersome. Typically, there are variety of flame-retardant materials that are different in terms of the type, the amount, and the size, along with processing (e.g., extrusion, and additive manufacturing), and practical (e.g., ultimate price, recyclability, and life cycle) parameters that should be optimized to reach a desired product. On a parallel front, the instructions, standards, and safety requirements bring about further difficulties and limitations with materials design and fire protection. For instance, Scientific Committee on Consumer Safety (SCCS) claasifies materials as non-food products and risky materials as well as consumer services, to highlight health considerations. Correspondingly, fire suppression, fire fighting, fire extinguishing or other terms are defined, but controlling all parameters contributing to consumer safety and customer services requires identification and integration of materials and safety factors into an intelligent system capable of searching, ranking and classifying them in a very disciplined yet quick manner for emergency needs. The performance of a material under fire, both fire reaction and fire resistance, significantly depends on the shape and the geometry of structures, more specifically on the fire dynamics during a defined fire situation along with the material, ventilated, and under-ventilated situations. The selection of testing methodology, would also affect the success of strategies used for fire protection. These all would necessitate a bewildering of scenarios to be identified, classified, and examined by researchers working in the field, which wastes a great deal of time, investment, and practice.
FIRE RISK ASSESSMENT IN INDUSTRIAL PREMISES
- Mariusz Jaczewski
- Marek Pszczoła
- Maciej Sawicki
2022
Chapter presents different aspects of fire risk assessment in industrial sites
Flame-Retardant Polymer Materials Developed by Reactive Extrusion: Present Status and Future Perspectives
- Henri Vahabi
- Fouad Laoutid
- Krzysztof Formela
- Mohammad Saeb
- Philippe Dubois
2022 Polymer Reviews
The development of flame retardant polymer materials has two roots, one in materials design, and the other in materials processing. Over recent decades, different types and classes of flame retardant polymer materials have been commercialized to meet safety requirements in the construction, automotive, and coatings industries. In the vast majority of cases, the design and fabrication of new materials presenting low fire hazards could be obtained through the incorporation of one, two or more flame retardants with similar or different natures into polymers. Nevertheless, the presence of these new phases, often used at high loading levels, usually impact the polymer’s other functional properties, such as mechanical, aging and transparency. These limitations could be partially or totally overcome using reactive extrusion, which is a promising process for developing new polymers or modifying the chemical structure of existing ones. Amongst other possibilities, reactive extrusion can be used for enhancing the fire behavior of existing polymers or for the synthesis of new ones presenting inherent flame retardant properties. In recent years, several new flame retardant polymers have been developed by reactive extrusion, but these developments have not been systematically described with regard to their technical circumstances, properties, and commercial potential. This short review attempts to overview and classify the available reports on the development of flame-retardant polymeric materials through reactive extrusion processes.
Flexomagneticity in buckled shear deformable hard-magnetic soft structures
- Mohammad Malikan
- Victor Eremeev
2022 Pełny tekst CONTINUUM MECHANICS AND THERMODYNAMICS
This research work performs the first time exploring and addressing the flexomagnetic property in a shear deformable piezomagnetic structure. The strain gradient reveals flexomagneticity in a magnetization phenomenon of structures regardless of their atomic lattice is symmetrical or asymmetrical. It is assumed that a synchronous converse magnetization couples both piezomagnetic and flexomagnetic features into the material structure. The mathematical modeling begins with the Timoshenko beam model to find the governing equations and non-classical boundary conditions based on shear deformations. Flexomagneticity evolves at a small scale and dominant at micro/nanosize structures. Meanwhile, the well-known Eringen’s-type model of nonlocal strain gradient elasticity is integrated with the mathematical process to fulfill the scaling behavior. From the viewpoint of the solution, the displacement of the physical model after deformation is carried out as the analytical solution of the Galerkin weighted residual method (GWRM), helping us obtain the numerical outcomes on the basis of the simple end conditions. The best of our achievements display that considering shear deformation is essential for nanobeams with larger values of strain gradient parameter and small amounts of the nonlocal coefficient. Furthermore, we showed that the flexomagnetic (FM) effect brings about more noticeable shear deformations’ influence.
Flexomagneticity in Functionally Graded Nanostructures
- Mohammad Malikan
- Tomasz Wiczenbach
- Victor Eremeev
2022 Pełny tekst
Functionally graded structures have shown the perspective of materials in a higher efficient and consistent manner. This study reports a short investigation by concentrating on the flexomagnetic response of a functionally graded piezomagnetic nano-actuator, keeping in mind that the converse magnetic effect is only taken into evaluation. The rule of mixture assuming exponential composition of properties along with the thickness is developed for the ferromagnetic bulk. Nonlocal effects are assigned to the model, respecting Eringen’s hypothesis. The derived equations deserve to be analytically solved. Therefore, numerical results are generated for fully fixed ends. It is denoted that the functionality grading feature of a magnetic nanobeam can magnify the flexomagnetic effect leading to high-performance nanosensors/actuators.
Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor
- Garima Shahi
- Mohit Kumar
- Andrzej Skwarecki
- Matt Edmondson
- Atanu Banerjee
- Jane Usher
- Neil A.R. Gow
- Sławomir Milewski
- Rajendra Prasad
2022 Pełny tekst Cell Surface
In 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particular concern because many strains are resistant to multiple class of antifungal drugs. The lack of available antifungals and rapid increase of this fungal pathogen provides an incentive for the development of new and more potent anticandidal drugs and drug combinatorial treatments. Here we have explored the growth inhibitory activity against C. auris of a synthetic dipeptide glutamine analogue, L-norvalyl-N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (Nva-FMDP), that acts as an inhibitor of glucosamine-6-phosphate (GlcN-6-P) synthase - a key enzyme in the synthesis of cell wall chitin. We observed that in contrast to FLC susceptible isolates of C. auris, FLC resistant isolates had elevated cell wall chitin and were susceptible to inhibition by Nva-FMDP. The growth kinetics of C. auris in RPMI-1640 medium revealed that the growth of FLC resistant isolates were 50–60% more inhibited by Nva-FMDP (8 g/ml) compared to a FLC susceptible isolate. Fluconazole resistant strains displayed increased transcription of CHS1, CHS2 and CHS3, and the chitin content of the fluconazole resistant strains was reduced following the Nva-FMDP treatment. Therefore, the higher chitin content in FLC resistant C. auris isolates may make the strain more susceptible to inhibition of the antifungal activity of the Nva-FMDP peptide conjugate
Fluid structure interaction study of non-Newtonian Casson fluid in a bifurcated channel having stenosis with elastic walls
- Hasan Shahzad
- Xinhua Wang
- Abuzar Ghaffari
- Kaleem Iqbal
- Muhammad Bilal Hafeez
- Marek Krawczuk
- Wiktoria Wojnicz
2022 Pełny tekst Scientific Reports
Fluid–structure interaction (FSI) gained a huge attention of scientists and researchers due to its applications in biomedical and mechanical engineering. One of the most important applications of FSI is to study the elastic wall behavior of stenotic arteries. Blood is the suspension of various cells characterized by shear thinning, yield stress, and viscoelastic qualities that can be assessed by using non-Newtonian models. In this study we explored non-Newtonian, incompressible Casson fluid flow in a bifurcated artery with a stenosis. The two-dimensional Casson model is used to study the hemodynamics of the flow. The walls of the artery are supposed to be elastic and the stenosis region is constructed in both walls. Suitable scales are used to transform the nonlinear differential equations into a dimensionless form. The problem is formulated and discretized using Arbitrary Lagrangian–Eulerian (ALE) approach. The finite element method (FEM) technique is used to solve the system of equations, together with appropriate boundary conditions. The analysis is carried out for the Bingham number, Hartmann number, and Reynolds number. The graphical results of pressure field, velocity profile, and load on the walls are assessed and used to study the influence of hemodynamic effects on stenotic arteries, bifurcation region, and elastic walls. This study shows that there is an increase in wall shear stresses (WSS) with increasing values of Bingham number and Hartmann number. Also, for different values of the Bingham number, the load on the upper wall is computed against the Hartmann number. The result indicate that load at the walls increases as the values of Bingham number and Hartmann number increase.
Fluid–Structure Interaction methods for the progressive anatomical and artificial aortic valve stenosis
- Marcin Nowak
- Eduardo Divo
- Wojciech P. Adamczyk
2022 INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
Cardiovascular system diseases, as aortic valve stenosis, are the main cause of mortality and morbidity among patients. There is still a room for enhancement of the diagnostic and therapeutic procedures, which will lead to improvement of the treatment. One of the remedies are the computer tools to support the medical diagnoses and prostheses design. The development of a procedure for modeling the aortic valves: anatomical tricuspid valve and artificial bileaflet valve, still is a very challenging task. In presented work, the application of the novel, advanced moving mesh model, that consists of the coupling of the dynamic mesh smoothing and the overset mesh technique, to speed up the computation and improve the convergence and stability was shown. The real 2D and 3D vasculature and valve geometries were created based on the echocardiography images available in literature. The calculations of anatomical and artificial valve models were performed for the various severity of the atherosclerosis — not previously published for the bileaflet mechanical valve. The impact of calcification process onto natural and artificial aortic valves was assessed and compared.
Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma
- Tomasz Cwalinski
- Jarosław Skokowski
- Wojciech Polom
- Luigi Marano
- Maciej Swierblewski
- Kamil Drucis
- Giandomenico Roviello
- Natalia Cwalina
- Leszek Kalinowski
- Franco Roviello
- Karol Polom
2022 Surgical Innovation
Introduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with skin melanoma, who were candidates for sentinel node biopsy were enrolled in our study. All patients underwent simultaneous use of standard nanocolloid and blue dye. Transcutaneous visualization of the sentinel node, visualization of lymphatic channels as well as sentinel node fl uorescent visualization were all measured. We also performed calculations of Signal to Background ratios (SBR). Results: In 15% (3/20) of patients, the fl uorescent sentinel node was visible through the skin. The median SBR for the sentinel node visualization by fl uorescence was 3.15 (range, 2.7 – 3.5). Lymphatic channels were visible in lymphatic tissue via fl uorescence before visualization by the naked eye in 4 patients (20%). The median SBR ratio was 3.69 (range, 2.7 – 4.2). Sentinel nodes were visible by fl uorescence in 13 cases (65%). The median SBR ratio was 2.49 (range, 1.5 – 5.7). No factors were found to be associated with fl uorescent MB visualization of a sentinel node during biopsy. Conclusion: This is the fi rst clinical study presenting the usefulness of fl uorescent sentinel node biopsy in melanoma patients using MB as a fl uorophore. Further studies are necessary to provide methods for its ’ clinical implementation.
Fluorescence of nanodiamond cocktails: pH-induced effects through interactions with comestible liquids
- Maciej Głowacki
- Mateusz Ficek
- Mirosław Sawczak
- Anna Wcisło
- Robert Bogdanowicz
2022 Pełny tekst FOOD CHEMISTRY
Fluorescent nanodiamonds with nitrogen-vacancy centers have become important nanoscale probes for sensing and imaging. The surface chemistry of the nanodiamonds influences their emission, interactions, and quantum properties. In this work, we propose to utilize fluorescent nanodiamonds as photostable markers for investigation of comestible liquids. We prepared nanodiamond/comestibles suspensions/cocktails with a wide range of pH levels and studied the samples via fluorescence, wettability, and zeta potential. The composition of the created cocktails revealed a strong impact on the properties of the nanodiamond and its surface chemistry, mainly induced by pH but also tuned by specific quenching compounds. Moreover, the stability of the nanodiamonds in the cocktail media was studied, along with various nature-originated compounds influencing their surface termination, polarity, and charge states. Thanks to the stability and biocompatibility of the nanodiamond, it can be applied in monitoring the condition of foodstuffs, and in the detection of toxins and pathogens in them.
Focused ion beam-based microfabrication of boron-doped diamond single-crystal tip cantilevers for electrical and mechanical scanning probe microscopy
- Ewelina Gacka
- Piotr Kunicki
- Andrzej Sikora
- Robert Bogdanowicz
- Mateusz Ficek
- Teodor Gotszalk
- Ivo W. Rangelow
- Krzysztof Kwoka
2022 Pełny tekst MEASUREMENT
In this paper, the fabrication process and electromechanical properties of novel atomic force microscopy probes utilising single-crystal boron-doped diamond are presented. The developed probes integrate scanning tips made of chemical vapour deposition-grown, freestanding diamond foil. The fabrication procedure was performed using nanomanipulation techniques combined with scanning electron microscopy and focused ion beam technologies. The mechanical properties of the cantilever were monitored by the measurement of thermally induced vibration of the cantilever after every fabrication step, allowing the mass changes in range of ng to be estimated. The endurance of the developed probes was tested during hundreds of topography measurements, which corresponds to a scanning length equal to 13.6 m, performed on a test sample in contact and lateral force microscopy modes. Analysis of the roughness parameters confirmed the extremely high wear resistance of the fabricated probes. The linear current voltage response on a highly-oriented pyrolytic graphite sample was recorded.
Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
- Joanna Pilch
- Patrycja Kowalik
- Agata Kowalczyk
- Piotr Bujak
- Artur Kasprzak
- Ewa Paluszkiewicz
- Ewa Augustin
- Anna M. Nowicka
2022 Pełny tekst INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Targeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound C-2028. C-2028 was bound to the nanoconjugate via an inclusion complex with β-CD. The effect of using FA in QDs-β-CD(C-2028)-FA nanoconjugates on cytotoxicity, cellular uptake, and the mechanism of internalization in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells was investigated. The QDs-β-CD(C-2028)-FA were characterized using DLS (dynamic light scattering), ZP (zeta potential), quartz crystal microbalance with dissipation (QCM-D), and UV-vis spectroscopy. The conjugation of C-2028 with non-toxic QDs or QDs-β-CD-FA did not change the cytotoxicity of this compound. Confocal microscopy studies proved that the use of FA in nanoconjugates significantly increased the amount of delivered compound, especially to cancer cells. QDgreen-β-CD(C-2028)-FA enters the cells through multiple endocytosis pathways in different levels, depending on the cell line. To conclude, the use of FA is a good self-navigating molecule in the QDs platform for drug delivery to cancer cells.