2022 - Repozytorium publikacji - Politechnika Gdańska

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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
- Agnieszka Potęga
2022 Pełny tekst MOLECULES
The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar and water-soluble glutathione S-conjugates, readily excreted outside the body. In this regard, glutathione plays a role in detoxification, decreasing the likelihood that a xenobiotic will react with cellular targets. However, some drugs once transformed into thioethers are more active or toxic than the parent compound. Thus, glutathione conjugation may also lead to pharmacological or toxicological effects through bioactivation reactions. My purpose here is to provide a broad overview of the mechanisms of glutathione-mediated conjugation of anticancer drugs. Additionally, I discuss the biological importance of glutathione conjugation to anticancer drug detoxification and bioactivation pathways. I also consider the potential role of glutathione in the metabolism of unsymmetrical bisacridines, a novel prosperous class of anticancer compounds developed in our laboratory. The knowledge on glutathione-mediated conjugation of anticancer drugs presented in this review may be noteworthy for improving cancer therapy and preventing drug resistance in cancers.
Gospodarka ciepłem
- Tomasz Minkiewicz
2022
Wymieniono zadania i wymagania stawiane scentralizowanym systemom zaopatrzenia w ciepło, scharakteryzowano nośniki ciepła i układy sieci cieplnych, opisano wybrane zagadnienia technologii i eksploatacji rurociągów ciepłowniczych oraz przedstawiono przykładowe układy wykorzystywane do skojarzonego wytwarzania energii elektrycznej i ciepła.
Gospodarka paliwami gazowymi
- Waldemar Kamrat
2022
Przedstawiono problematykę gospodarowania paliwami gazowymi. Określono potencjał produkcji wodoru w Polsce. Przedstawiono aspekty ekonomiczne transportu rurociągowego.
GPU Power Capping for Energy-Performance Trade-Offs in Training of Deep Convolutional Neural Networks for Image Recognition
- Adam Krzywaniak
- Paweł Czarnul
- Jerzy Proficz
2022 Pełny tekst
In the paper we present performance-energy trade-off investigation of training Deep Convolutional Neural Networks for image recognition. Several representative and widely adopted network models, such as Alexnet, VGG-19, Inception V3, Inception V4, Resnet50 and Resnet152 were tested using systems with Nvidia Quadro RTX 6000 as well as Nvidia V100 GPUs. Using GPU power capping we found other than default configurations minimizing three various metrics: energy (E), energy-delay product (EDP) as well as energy-delay sum (EDS) which resulted in considerable energy savings, with a low to medium performance loss for EDP and EDS. Specifically, for Quadro 6000 and minimization of E we obtained energy savings of 28.5%–32.5%, for EDP 25%–28% of energy was saved with average 4.5%–15.4% performance loss, for EDS (k = 2) 22%–27% of energy was saved with 4.5%–13.8% performance loss. For V100 we found average energy savings of 24%–33%, for EDP energy savings of 23%–27% with corresponding performance loss of 13%–21% and for EDS (k = 2) 23.5%–27.3% of energy was saved with performance loss of 4.5%–13.8%.
Grafo-ania, czyli rzecz o grafach i algorytmach. Drzewa Steinera
- Marek Kubale
2022 Pismo PG
Problem: na płaszczyźnie leżą 3 punkty. Znajdź czwarty, taki że jego sumaryczna odległość od 3 pozostałych jest minimalna, Pokazujemy jak rozwiązać ten problem i jego uogólnienie.
Grafo-mania, czyli rzecz o grafach i algorytmach. Liczby Ramseya
- Marek Kubale
2022 Pismo PG
Zdefiniowano liczby Ramseya i wskazano na trudności obliczeniowe ich wyznaczania już przy niewielkich wartościach takich liczb.
Grafo-mania, czyli rzecz o grafach i algorytmach. Problem 8 hetmanów
- Marek Kubale
2022 Pismo PG
W eseju spojrzano na problem 8 hetmanów na szachownicy z punktu widzenia teorii grafów
Grafo-mania, czyli rzecz o grafach i algorytmach. Szybkie mnożenie macierzy
- Marek Kubale
2022 Pismo PG
Miniesej zawiera komentarz na temat zastosowania sztucznej inteligencji do problemu mnożenia macierzy.
Grafting and reactive extrusion technologies for compatibilization of ground tyre rubber composites: Compounding, properties, and applications
- Mapoloko Mpho Phiri
- Mohau Justice Phiri
- Krzysztof Formela
- Shifeng Wang
- Shanganyane Percy Hlangothi
2022 JOURNAL OF CLEANER PRODUCTION
Chemical modification of ground tyre rubber (GTR) to compatibilize it with the matrix is a well-known approach. Based on our recent review of the surface etching methods used in GTR modification, the purpose of the current work is to take a deeper look into more advanced methods such as grafting and reactive extrusion. While grafting is more efficient in achieving compatibility, however, it usually involves multi-step synthesis protocol and purification procedures making it very difficult to be applied in the industry. On the other hand, reactive extrusion is easy to apply in the industry as it uses the same equipment that is already employed in the rubber and thermoplastics industries. Furthermore, it is solvent-free and achieves compatibility via in-situ grafting of GTR and the matrix. The composites properties achieved via each of these processes and the resulting properties are highlighted in this work. For grafting, the initiation methods used to introduce an active centre onto the GTR are also highlighted.
Granie nie tylko na murawie! Zostań Lewandowskim pipety i termocyklera. Synergia nowoczesnych metod analitycznych opartych o wykrywanie DNA z nowymi formami nauczania (grywalizacja).
- Paweł Filipkowski
2022 Pełny tekst Pismo PG
KOnkurs Innowacji Dydaktyznych PG: "Granie nie tylko na murawie! Zostań Lewandowskim pipety i termocyklera. Synergia nowoczesnych metod analitycznych opartych o wykrywanie DNA z nowymi formami nauczania (grywalizacja)."
Graphene Reinforced Phenolic Foams
- Michał Strankowski
2022 Pełny tekst
Phenolic foams (PF) belong to the polymeric materials, which are very attractive from the point of many possible applications such as insulation or fire protection materials. This chapter attempts to explain the influence of graphene and graphene derivatives on the phenolic foams. This work briefly presents different graphene nanoparticles introduced to the phenolic foams matrix, in terms of impact on the thermal, mechanical, and cell structure (morphological) behavior. In particular, the characterization of the morphology of polymer systems reinforced with graphene derivatives has received considerable attention. Due to the correlation resulting from the influence of structure on the macroscopic properties of this group of materials. This study also focuses on the presentation of various (experimental) methods enabling the introduction of graphene nanoparticles into the phenolic matrix. The presented chapter summarizes the work carried out on the modification of phenolic foams with the graphene derivatives, which seem to be a promising nanomodifiers of these materials in connection with obtaining completely new valuable properties.
Graphene-Coated PVDF Membranes: Effects of Multi-Scale Rough Structure on Membrane Distillation Performance
- Emilia Gontarek-Castro
- Giuseppe Di Luca
- Marek Lieder
- Annarosa Gugliuzza
2022 Pełny tekst Membranes
Graphene-coated membranes for membrane distillation have been fabricated by using a wet-filtration approach. Graphene nanoplatelets have been deposited onto PVDF membrane surfaces. Morphology and physicochemical properties have been explored to evaluate the changes in the surface topography and related effects on the membrane performance in water desalination. The membranes have been tested in membrane distillation plants by using mixtures of sodium chloride and humic acid. The multi-scale rough structure of the surface has been envisaged to amplify the wetting and fouling resistance of the graphene-coated membranes so that a better flux and full salt rejection have been achieved in comparison with pristine PVDF. Total salt rejection and an increase of 77% in flux have been observed for coated membrane with optimized graphene content when worked with NaCl 0.6 M (DCMD, ΔT ≈ 24 °C) over a test period of 6 h. The experimental findings suggest these novel graphene-coated membranes as promising materials to develop functional membranes for high-performing water desalination.
Graphical interface adaption for children to explain astronomy proportions and distances
- Kim García Martínez
- Jacek Lebiedź
- Andrés Iglesias Bustillo
2022
Mobile Science Center is a Polish project that seeks to bring astronomy knowledge to wider social groups through various applications. In its development it is necessary to design a graphical interface that explains a concept that is difficult to assimilate such as spatial proportions and distances. This paper develops a framework to create graphical representations that explain this learning to the target audience of children. Important aspects of this interface are the inclusion of storytelling to guide the educational content, along with feedback and difficulty and accessibility adaptations. Regarding spatial representation, previous works highlight the use of shapes and geometric objects, cartographic tools, reference points, and comparison with known velocities and spaces. The graphical interface proposed is based on a decimal system scale that compares traveling at the speed of light with a person walking. There are 4 proposals that represent the units of this scale with different geometric shapes and interrelated structures, in addition to assigned colors and positions. Future development of this project will apply these ideas to identify the optimal graphical interface so children can learn spatial proportions and distances.
Green analytical chemistry metrics: A review
- Muhammad Sajid
- Justyna Płotka-Wasylka
2022 TALANTA.The International Journal of Pure and Applied Analytical Chemistry
Green analytical chemistry encourages reducing the use of toxic chemicals/reagents, using energy-efficient equipment, and generating minimal waste. The recent trends in analytical method development focus on the miniaturization of the sample preparation devices, the development of solventless or solvent-minimized extraction techniques, and the utilization of less toxic solvents. The twelve principles of GAC serve as a basic guideline for inducing greenness in the analytical procedures. Despite these guidelines, in many conditions, some undesired steps are unavoidable. Therefore, it is important to evaluate the greenness of analytical procedures to assess and, if possible, reduce their impact on the environment and workers. Several metrics have been developed for the evaluation of the greenness of analytical procedures. Analytical Eco-Scale, Green Analytical Procedure Index, and Analytical Greenness Metric are among some important tools for assessing the greenness of analytical procedures. All these metrics take different aspects of the analytical procedure into account to provide the green index of the procedure. This review covered these metrics, their principles, and examples of their application to selected analytical procedures. The advantages and limitations of these metrics with the perspective of common reader/user are presented. We believe that this paper will inspire many new perspectives and developments in this area.
Green, blue and energy in cities
- Katarzyna Weinerowska-Bords
2022 Energetyka Wodna
The article refers to the implementation of blue-green infrastructure in cities, with particular emphasis on the aspect of rainwater and energy management. The article presents the advantages of water and greenery in the city and gives examples of engineering solutions used, both the more popular (including green and biosolar roofs), as well as experimental solutions, which are an interesting and necessary alternative in the era of energy transformation of cities.
Green capsule phase microextraction employing hydrophobic monolithic sol-gel octadecyl siloxane platforms for the monitoring of organophosphorus pesticides in environmental water samples
- Natalia Manousi
- Antonio Ferracane
- Abuzar Kabir
- Kenneth G. Furton
- Peter Q. Tranchida
- George A. Zachariadis
- Justyna Płotka-Wasylka
- Luigi Mondello
- Victoria F. Samanidou
- Erwin Rosenberg
2022 Sustainable Chemistry and Pharmacy
In this study, a novel, facile and green capsule phase microextraction (CPME) method is presented for the extraction and preconcentration of organophosphorus pesticides (i.e., chlorpyrifos, disulfoton, ethoprophos, fenchlorphos, prothiofos, and parathion-methyl) from environmental water samples. Monolithic sol-gel octadecyl siloxane (sol-gel C18) sorbent encapsulated within porous polypropylene capsules was synthesized, characterized, and evaluated for its efficiency towards the adsorption of the target organophosphorus pesticides. CPME was combined with gas chromatography-mass spectrometry (GC-MS) for the monitoring of the target analytes. The method was optimized to ensure high method sensitivity and it was fully validated. The limits of detection of the CPME-GC-MS method for the OPPs were 0.02–0.15 ng mL−1. The relative standard deviations were 1.5–8.7% for intra-day study and 5.4–9.6% for inter-day study, demonstrating satisfactory precision. Moreover, good method accuracy was obtained, since the relative recoveries were within the range 92.6–107.0% and 90.8–107.6% for intra-day and inter-day (c = 5.00 and 20.0 ng mL−1), respectively. The absence of interferences in the blank samples demonstrates that the proposed method is selective. The sol-gel C18 sorbent encapsulated CPME media could be reused for at least 25 adsorption/desorption cycles. In addition, the methodology presents advantageous features in comparison to existing methods. The final protocol was used for analyzing four different water sample types (i.e., lake water, river water, pond water and tap water sample).
Green energy extraction for sustainable development: A novel MPPT technique for hybrid PV-TEG system
- Muhammad Kamran Khan
- Muhammad Hamza Zafar
- Majad Mansoor
- Adeel Mirza
- Umer Amir Khan
- Noman Mujeeb Khan
2022 Sustainable Energy Technologies and Assessments
The Photovoltaic (PV) module converts only a small portion of irradiance into electrical energy. Most of the solar energy is wasted as heat, resulting in a rise in PV cell temperature and a decrease in solar cell efficiency. One way to harvest this freely available solar thermal energy and improve PV cell efficiency is by integrating PV systems with thermoelectric generators (TEG). This cogeneration approach of the hybrid PV-TEG system uses waste heat as an energy production source, resulting in higher output power density. Furthermore, as hybrid PV-TEG systems are frequently used in dynamic environments with temperature and irradiance variations, it is critical to modify the electrical operating points effectively and precisely to maximize the collected power, a process known as maximum power point tracking (MPPT). Under stochastic environmental conditions, a properly chosen MPPT technique can improve the generation efficiency from 10 to 15%. Therefore, in this study a novel implementation of atomic orbital search optimization algorithm is presented for MPPT tracking. Several case studies are designed to test AOS based MPPT algorithm performance under stochastic operating conditions. The effectiveness of the proposed algorithm is validated by comparing it with the conventional Perturb and Observe (P&O) algorithm and other highly-efficient metaheuristic algorithms such as Grasshopper Optimization (GHO), Particle swarm optimization (PSO), and Grey Wolf Optimization (GWO). AOS based controller extracts 6% more energy and tracks optimal power at an efficiency of 99.984% under various test scenarios. The tracking time is improved by 616.48% as compared to PSO. Experimental, quantitative, comparative, and statistical results demonstrate the AOS-based proposed technique’s superior performance under various practical conditions.
Green monoterpenes based deep eutectic solvents for effective BTEX absorption from biogas
- Patrycja Makoś-Chełstowska
- Edyta Słupek
- Aleksandra Kramarz
- Dominik Dobrzyniewski
- Bartosz Szulczyński
- Jacek Gębicki
2022 CHEMICAL ENGINEERING RESEARCH & DESIGN
The combustion of biogas which contains significant amounts of monoaromatic hydrocarbons, i.e. benzene, ethylbenzene, toluene, and xylene (BTEX) can cause many technological, environmental, and health problems. Therefore, in these studies, a new physical absorption method based on deep eutectic solvents (DES) consisting of monoterpenes and carboxylic acids was developed for BTEX removal. A total of 39 DES were synthesized, of which seven were selected based on their affinity to BTEX, favorable physicochemical properties, and “green” character. Detailed structural (i.e. 1H NMR, 13C NMR, and FT-IR) and physicochemical experiments (i.e. melting point, density, viscosity, and surface tension) were performed for the DES. Then, DESs were used for the absorption process in both the laboratory and enlarged scale. BTEX absorption was monitored using two methods, including "in-situ" gas chromatography, and "online" sensors matrices. The crucial absorption parameters i.e. type of DES, temperature, and regeneration possibility were carefully studied. The mechanism of BTEX absorption was explained using experimental spectroscopic techniques and theoretical analysis based on the COSMO-RS model. The obtained results indicate that Eucalyptol:Octanoic acid can selectively capture BTEX from a biogas mixture due to the formation of electrostatic interaction. DES absorption capacity is 53.96 mg/g, which is comparable with commercially available absorbents.
Green Polymer Nanocomposites for Skin Tissue Engineering
- Hanieh Shokrani
- Amirhossein Shokrani
- Maryam Jouyandeh
- Farzad Seidi
- Fatemeh Gholami
- Saptarshi Kar
- Muhammad Tajammal Munir
- Daria Kowalkowska-Zedler
- Payam Zarrintaj
- Navid Rabiee
- Mohammad Saeb
2022 ACS Applied Bio Materials
Fabrication of an appropriate skin scaffold needs to meet several standards related to the mechanical and biological properties. Fully natural/green scaffolds with acceptable biodegradability, biocompatibility, and physiological properties quite often suffer from poor mechanical properties. Therefore, for appropriate skin tissue engineering and to mimic the real functions, we need to use synthetic polymers and/or additives as complements to green polymers. Green nanocomposites (either nanoscale natural macromolecules or biopolymers containing nanoparticles) are a class of scaffolds with acceptable biomedical properties window (drug delivery and cardiac, nerve, bone, cartilage as well as skin tissue engineering), enabling one to achieve the required level of skin regeneration and wound healing. In this review, we have collected, summarized, screened, analyzed, and interpreted the properties of green nanocomposites used in skin tissue engineering and wound dressing. We particularly emphasize the mechanical and biological properties that skin cells need to meet when seeded on the scaffold. In this regard, the latest state of the art studies directed at fabrication of skin tissue and bionanocomposites as well as their mechanistic features are discussed, whereas some unspoken complexities and challenges for future developments are highlighted.
Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment
- Navid Rabiee
- Yousef Fatahi
- Mohsen Asadnia
- Hossein Daneshgar
- Mahsa Kiani
- Amir Mohammad Ghadiri
- Monireh Atarod
- Amin Hamed Mashhadzadeh
- Omid Akhavan
- Mojtaba Bagherzadeh
- Eder C. Lima
- Mohammad Saeb
2022 JOURNAL OF HAZARDOUS MATERIALS
Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like K+ in the inner and middle ear may permanently damage the ear system. We synthesized nanoplatforms based on Allium noeanum to take the first steps in developing biological porous nanomembranes for hazardous cation detection in biological media. The 1,1,1-tris[[(2′-benzyl-amino-formyl)phenoxy]methyl]ethane (A), 4-amino-benzo-hydrazide (B), and 4-(2-(4-(3-carboxy-propan-amido)benzoyl)hydrazineyl)-4-oxobutanoic acid (B1) were synthesized to obtain green ligands based on 4-X-N-(…(Y(hydrazine-1-carbonyl)phenyl)benzamide, with X denoting fluoro (B2), methoxy (B3), nitro (B4), and phenyl-sulfonyl (B5) substitutes. The chemical structure of ligand-decorated adenosine triphosphate (ATP) molecules (S-ATP) was characterized by FTIR, XRD, AFM, FESEM, and TEM techniques. The cytotoxicity of the porous membrane was patterned by applying different cell lines, including HEK-293, PC12, MCF-7, HeLa, HepG2, and HT-29, to disclose their biological behavior. The morphology of cultured cells was monitored by confocal laser scanning microscopy. The sensitivity of S-ATP to different cations of Na+, Mg2+, K+, Ba2+, Zn2+, and Cd2+ was evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES) in terms of extraction efficiency (η). For pH of 5.5, the η of A-based S-ATP followed the order Na+ (63.3%) > Mg2+ (62.1%) > Ba2+ (7.6%) > Ca2+ (5.5%); while for pH of 7.4, Na+ (37.0%) > Ca2+ (33.1%) > K+ (25.7%). The heat map of MTT and dose-dependent evaluations unveiled acceptable cell viability of more than 90%. The proposed green porous nanomembranes would pave the way to use multifunctional green porous nanomembranes in biological membranes.