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Ostatnie pozycje
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Optimum number of actuators to minimize the cross-sectional area of prestressable cable and truss structures
- Ahmed Manguri
- Najmadeen Saeed
- Farzin Kazemi
- Marcin Szczepański
- Robert Jankowski
This paper describes a new computational method for determining the optimum number of actuators to design the optimal and economic cross-sectional area of pin-jointed assemblies based on the conventional force method. The most active members are selected to be prestressed to redistribute stress in the whole structure, resulting in regulating the internal force of bars that face high stress. Reducing stress in critical members allows the designers to select smaller cross-sectional areas than before. Furthermore, the maximum absolute displacement of the structures before the optimization is set as a limit for the displacement of the optimized structures. The derived equations from the force method are subjected to the optimization algorithms (i.e., sequential quadratic programming (SQP), trust-region reflective, active set, and interior point) to minimize the necessary number of actuators for prestressing. The optimization procedure is done in two ways: first, by minimizing the number of actuators for prestressing through implementing the fmincon function, and second, by selecting the most economical area via prestressing the structure before loading. The method is applied to the numerical models of two cable and four truss structures that were previously studied. The outcomes show that by actuating as few actuators as possible, the area of cable and truss structures can be minimized up to 17% and 27 %, respectively. Moreover, 5% improvement can be obtained applying the current technique to the optimized trusses by quoted methods. The outcomes are compared with results from the literature. Moreover, the results obtained from MATLAB are verified by SAP2000 software.
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Optimum shapes and dimensions of rubber bumpers in order to reduce structural pounding during seismic excitations
- Seyed Mohammad Khatami
- Hosein Naderpour
- Alireza Mortezaei
- M. Maddah
- Natalia Lasowicz
- Robert Jankowski
Large displacement of structures observed during seismic excitations may lead to collisions between two adjacent, insufficiently-separated buildings and may result in major damages of both of them. In many building codes, appropriate equations or approximately recommended distances between structures in order to avoid pounding hazard have been introduced. Unfortunately, further, more detailed considerations show that safety situation or economic aspects are not always satisfied due to the collisions between buildings and the cost of land, respectively. Hence, researchers have studied other approaches of reducing the negative pounding effects. Such methods include the use of tuned mass or liquid dampers. Moreover the increase in stiffness of building or reduction of mass of the structure are still considered. In this paper, another approach is considered by the application of rubber bumpers placed between buildings. The bumpers are attached at each story to absorb energy during impact. Several different shapes and dimensions of bumper elements were numerically investigated so as to find the most effective ones most effective in reducing structural pounding negative effects. For this purpose, two MDOF models of 3-story and 4-story buildings were firstly considered. Such parameters as lateral displacement, damage index, dissipated energy and impact forces were calculated and depicted as the results of numerical study. Then, different shapes and dimensions of bumpers were parametrically investigated.
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Optymalizacja doboru prawa konstytutywnego membrany o strukturze plecionej
- Daniil Reznikov
Celem niniejszej dysertacji jest opracowanie zagadnienia optymalizacyjnego pozwalającego dobrać model konstytutywny opisujący mechaniczne zachowanie membrany technicznej. Do analizy wybrano membrany plecione, stosowane w medycynie, tzw. siatki chirurgiczne. W celu wykonania identyfikacji praw konstytutywnych, wykonano dwuosiowe rozciąganie próbek materiałów, otrzymując wskazanie na nieliniowe anizotropowe zachowanie materiałów. W wyniku tego, do opisania zależności pomiędzy naprężeniem, a odkształceniem przyjęto teorię hipersprężystości. Przeprowadzone z różnymi sterowaniami testy mechaniczne próbek doprowadziły do uzyskania różnych kompletów parametrów rozważanych praw konstytutywnych. W celu identyfikacji prawa opisującego pracę materiałów w warunkach naturalnych przeprowadzono analizę optymalizacyjną w której funkcja celu odnosi się do pozycji maksymalnej reakcji podporowej wyznaczonej w modelu numerycznym implantu oraz do pozycji maksymalnej reakcji wyznaczonej eksperymentalnie. Przeprowadzona analiza wskazuje, że model konstytutywny membrany plecionej silnie zależy od rodzaju wykonanego testu mechanicznego materiału, a wybór prawa opisującego rzeczywistą pracę danego materiału może być zrobiony w odniesieniu do eksperymentu z symetrycznym obciążeniem danego materiału.
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Optymalizacja zasobów chmury obliczeniowej z wykorzystaniem inteligentnych agentów w zdalnym nauczaniu
- Piotr Dryja
Rozprawa dotyczy optymalizacji zasobów chmury obliczeniowej, w której zastosowano inteligentne agenty w zdalnym nauczaniu. Zagadnienie jest istotne w edukacji, gdzie wykorzystuje się nowoczesne technologie, takie jak Internet Rzeczy, rozszerzoną i wirtualną rzeczywistość oraz deep learning w środowisku chmury obliczeniowej. Zagadnienie jest istotne również w sytuacji, gdy pandemia wymusza stosowanie zdalnego nauczania na dużą skalę lub rosnące koszty efekty ograniczają naukę stacjonarną. W dysertacji opracowano model alokacji inteligentnych agentów pedagogicznych, modułów systemu zdalnego nauczania oraz solwerów do serwerów w chmurze. Sformułowano zagadnienie wyznaczania reprezentacji rozwiązań Pareto-optymalnych. Opracowano wielokryterialny algorytm ewolucji różnicowej, za pomocą którego minimalizuje się cztery kryteria takie, jak: obciążenie CPU newralgicznego hosta, obciążenie komunikacyjne krytycznego węzła, koszt serwerów oraz łączny pobór mocy elektrycznej. W celu eksperymentalnej weryfikacji poprawności modelu zaprojektowano demonstrator chmury edukacyjnej w oparciu o wybrane zasoby Politechniki Gdańskiej oraz Politechniki Warszawskiej. Przeprowadzono wielowariantowe symulacje migracji inteligentnych agentów w środowisku Moodle na platformie OpenStack. Eksperymenty numeryczne potwierdziły, że wykorzystanie wielokryterialnej metaheurystyki opartej na ewolucji różnicowej umożliwia wyznaczenie wyższej jakości rozwiązań niezdominowanych niż rozwiązania uzyskane za pomocą innych metaheurystyk, takich jak: algorytm ewolucyjny, programowanie genetyczne, algorytm wyszukiwania harmonii oraz algorytm roju cząstek.
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Organic Supercritical Thermodynamic Cycles with Isothermal Turbine
- Marian Piwowarski
- Krzysztof Kosowski
- Marcin Richert
Organic Rankine cycles (ORC) are quite popular, but the overall efficiencies of these plants are rather very low. Numerous studies have been conducted in many scientific centers and research centers to improve the efficiency of such cycles. The research concerns both the modification of the cycle and the increase in the parameters of the medium at the inlet to the turbine. However, the efficiency of even these modified cycles rarely exceeds 20%. The plant modifications and the optimization of the working medium parameters, as a rule, lead to cycles with the high pressure and high temperature of live vapor and with a regenerator (heat exchanger) for the heating, vaporization and superheating of the medium. A new modified cycle with supercritical parameters of the working medium and with a new type of turbine has been described and calculated in the paper. For the first time, the isothermal turbine is proposed for supercritical organic cycles, though this solution is known as the Ericsson cycle for gas turbines. The innovative cycle and the usual ORC plants are characterized by almost identical block diagrams, while in the proposed cycle, the work of the turbine is obtained as a result of isothermal expansion and not in an adiabatic process. The analysis has been performed for 11 different working media and two cycles. The calculations have shown that power plants with isothermal expansion achieve better efficiency than cycles with adiabatic turbines. For example, the rise in efficiency changes from 8 percentage points for R245fa up to 10 percentage points for acetone. The calculations have proved that it is possible to obtain efficiency exceeding 50% for organic power plants. This is an outstanding result compared with modern steam and gas turbine units.
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Orientation-aware ship detection via a rotation feature decoupling supported deep learning approach
- Xinqiang Chen
- Hao Wu
- Bing Han
- Wei Liu
- Jakub Montewka
- Ryan Wen Liu
Ship imaging position plays an important role in visual navigation, and thus significant focuses have been paid to accurately extract ship imaging positions in maritime videos. Previous studies are mainly conducted in the horizontal ship detection manner from maritime image sequences. This can lead to unsatisfied ship detection performance due to that some background pixels maybe wrongly identified as ship contours. To address the issue, we propose a novel rotational you only look once (YOLO) based model (RYM) to accurately yet fast detect ships from maritime images by considering ship rotation angle. The proposed RYM model are designed to detect tilted ships from images with the help of a rotation decoupled (RD) head, attentional mechanism and bidirectional feature network (BiFPN). The experimental results suggested that RYM can obtain satisfied ship detection performance considering that average accuracy reaches 96.7%. The precision and recall indicators are 93.2% and 94.7%, respectively. The proposed framework can be applied into real-time ship detection task due to that the processing speed is 45.6 frames per second (FPS).
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Orunia # PRZYSTANEK W PODRÓŻY wystawa projektowych prac studenckich
- Agnieszka Kurkowska
- Alicja Karaś
Podróżujemy. Lokalnie i pokonując granice. Przenosimy się z potrzeby i konieczności. Przenosimy się w czasie I w wyobraźni. Przywołujemy wspomnienia, marzymy. Podróż wymaga przystanków: czasu wypoczynku i czasu refleksji. Podróż przez życie wymaga od nas stworzenia zrównoważonego schronienia dla naszej fizycznej egzystencji. Nikt z nas nie istnieje w odosobnieniu. Otacza nas przyroda, dotyczy dziedzictwo, które współtworzymy, dotykają codzienne problemy. łączy troska o planetę. Wspólny system wartości i dążenia kierunkują naszą podróż. Spotykamy w niej innych ludzi i przyglądamy się samym sobie. Studenci przygotowali propozycje obiektów architektonicznych ulokowanych na terenie Oruni, które są „PRZYSTANKAMI W PODRÓŻY”.
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Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
- Łukasz Pawłowski
- Szymon Mania
- Adrianna Banach-Kopeć
- Michał Bartmański
- Anna Ronowska
- Kacper Jurak
- Aleksandra Mielewczyk-Gryń
- Natalia Karska
- Sylwia Rodziewicz-Motowidło
- Andrzej Zieliński
Metallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid or a carbon dioxide saturation process. The coatings were deposited using a voltage of 10 V for 1 min. The prepared coatings were examined using SEM, EDS, FTIR, and XPS techniques. In addition, the wettability of these surfaces, corrosion resistance, adhesion of the coatings to the metallic substrate, and their antimicrobial activity (E. coli, S. aureus) and cytocompatibility properties using the MTT and LDH assays were studied. The coatings produced tightly covered the metallic substrate. Spectroscopic studies confirmed that the peptide did not detach from the chitosan chain during electrophoretic deposition. All tested samples showed high corrosion resistance (corrosion current density measured in nA/cm2). The deposited coatings contributed to a significant increase in the antimicrobial activity of the samples against Gram-positive and Gram-negative bacteria (reduction in bacterial counts from 99% to, for CS-RGD-Acid and the S. aureus strain, total killing capacity). MTT and LDH results showed high compatibility with bone cells of the modified surfaces compared to the bare substrate (survival rates above 75% under indirect contact conditions and above 100% under direct contact conditions). However, the adhesion of the coatings was considered weak.
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Overcoming Challenges of Virtual Scrum Teams: Lessons Learned Through an Action Research Study
- Jędrzej Babło
- Bartosz Marcinkowski
- Adam Przybyłek
After the COVID-19 breakout, agile teams found themselves in situations that “pure agilists” and textbooks on agile methods had preferred to ignore. Whereas agile mindsets helped them to quickly shift to remote work, mere virtualization of agile practices often proved insufficient, and several challenges emerged. This paper reports on an Action Research project carried out in Lufthansa Systems Poland with the aim of (1) revisiting their ad-hoc actions to adapt to remote work; and (2) elaborating systematic solutions to maintain efficiency in such a setting. With our assistance, the participating teams found measures to mitigate issues posed by the new work environment. They devised an inter-team communication model to improve the effectiveness of information exchange that had declined in the absence of spontaneous, face-to-face communication. Moreover, they employed several other mitigation strategies, including working at least one day per week in the office, keeping webcams on during online meetings, and recapping meetings at the end of a session. Our study largely supports previous findings indicating that Scrum can be effectively applied beyond its comfort zone but also suggests that for adaptations to be successful and comprehensive, they should be developed in a structured manner.
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Overview of new product development strategies and models
- Alina Guzik
Motivation: The motivation for the overview presented in this article is to provide a starting point for considering whether existing new product development methodology and its level of detail allows product teams to develop high-quality and business-effective product concepts. Aim: The aim of this article is recognise the current state of research into new product development methodology and to present the strategies and models for New Product Development (NPD). Materials and methods: The systematic review of the literature was applied in the article. Results: The first section outlines the main strategies for new product development and how they are divided by methodological stance, degree of planning, search pattern, focus and response. The second part discusses the known models of new product development including: the craft model and the 5 generations based on the innovation models described by Rothwell and the stages of the manufacturing process defined in the literature. Part four looks at new trends in new product development, including: Open Innovation, Rapid Product Development (RPD), Agile New Product Development (ANPD), Sustainable New Product development (SNPD), the Design Thinking method and the new technologies of Industry 4.0.
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Overview of the Synthesis and Catalytic Reactivity of Transition Metal Complexes Based on C═P Bond Systems
- Aleksandra Ziółkowska
- Doroszuk Justyna
- Łukasz Ponikiewski
This report provides an overview of the use of phosphaalkenes (C=P) in syntheses of various complexes. Going through successive complexes containing the d-block metals, we sought how this area of chemistry was formed over the years. Additionally, this work contains information on the possible coordination types and means of constructing the complexes. In addition, this review reveals the reactivities of phosphaalkene complexes with a strong emphasis on catalytic properties.
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Oxide nanoparticle exsolution in Lu-doped (Ba,La)CoO3
- Daria Balcerzak
- Iga Szpunar
- Ragnar Strandbakke
- Sarmad W. Saeed
- Calliope Bazioti
- Aleksandra Mielewczyk-Gryń
- Piotr Winiarz
- Alfonso Carrillo
- Maria Balaguer
- José M Serra
- Maria Gazda
- Sebastian Wachowski
This study investigated Lu doping of Ba0.5La0.5CoO3 and its influence on the exsolution of oxide nanoparticles (NPs). As a result of Lu doping, we observed the phase segregation into the main Ba0.4La0.6Co0.85Lu0.15O3 (BLCO–Lu) phase and the secondary Ba0.85La0.15Co0.75Lu0.25O3 (BCO–Lu) phase. We noticed the exsolution of BCO–Lu nanoparticles on the main BLCO–Lu phase. Moreover, the BLCO–Lu phase exsolved in the form of nanoparticles on the adjacent BCO–Lu grains. That shows that the phases are covered with mutually exsolved oxide NPs. In addition, trace amounts of the BaLuCo4O7 phase are detected. We noticed that the exsolved oxides even in the as-prepared sample were fine (average size of 18 nm), and well distributed with a dense population of NPs above 280 per 1 μm2. Furthermore, we showed that the size and shape of the exsolved oxide NPs can be controlled by varying the annealing temperature. For example, at 800 °C the exsolved oxides segregate and form two different shapes; spherical and cuboidal, with an average size of 31 nm and NP population of about 23 NPs per μm2. Meanwhile, with lowering the temperature to 400 °C the oxides form only spherical and quite evenly distributed NPs with the occurrence of 137 NPs per 1 μm2. The obtained results open the possibility of tailoring a novel, more catalytically active material for future applications in electrochemical devices.
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Oxygen vacancy-enriched V2O5·nH2O nanofibers ink for universal substrates-tolerant and multi means-integratable NH3 sensing
- Xiaxia Xing
- Xinhua Zhao
- Zhenxu Li
- Lingling Du
- Chen Wang
- Dongliang Feng
- Dongsheng Geng
- Robert Bogdanowicz
- Dachi Yang
Universal substrates-tolerant and multi means-integratable ammonia (NH3) sensing is highly desired in future Internet of Things in environmental monitoring, food security and early diagnosis of human diseases, however, is still less than satisfactory. Here, an oxygen vacancy-governed NH3 sensing has been developed with V2O5·nH2O nanofibers (NFs) ink, via combined thermal decomposition of ammonium metavanadate and dilution. As-obtained NH3 sensing ink takes on red colloids, in which the V2O5·nH2O NFs around 14 nm in diameter are interconnected. Beneficially, the fabric fiber decorated with V2O5·nH2O NFs ink displays excellent selectivity and ppb-concentration detection limit. Remarkably, V2O5·nH2O NFs ink is integrated over “hard” and “flexible” substrates such as glass, wood, paper, leaf and fabric with excellent tolerance by multi-integratable means such as writing, dipping and sewing. Theoretically, such NH3 sensing is interpreted that the bonding between V2O5 NFs and H2O modulates oxygen vacancy and thus adsorption sites, and the incorporation between crystal water and free one contributes to stable ink. Practically, A sensing device built with V2O5·3.1H2O NFs ink has been simulated to communicate with a smartphone with reliable NH3 sensing.
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Oznaczanie zanieczyszczeń pierwiastkowych w wyrobach ceramicznych wytwarzanych z dodatkiem różnych odpadów poprodukcyjnych
- Aleksandra Liczbińska
- Bartłomiej Cieślik
Niektóre odpady zawierające związki toksyczne mogą zostać immobilizowane w nierozpuszczalnej matrycy materiału poprzez zmieszanie odpadów z materiałami stanowiącymi podstawowe surowce w producji
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P92 steel and inconel 617 alloy welds joint produced using ERNiCr-3 filler with GTAW process: Solidification mechanism, microstructure, mechanical properties and residual stresses
- Amit Kumar
- Shailesh M. Pandey
- Sachin Sirohi
- Dariusz Fydrych
- Chandan Pandey
The objective of the current study was to analyse the microstructure, mechanical characteristics, and residual stresses of a dissimilar welded joint (DWJ) made of P92 steel and the Inconel alloy 617 (IN617) using the gas tungsten arc welding (GTAW) method. The ERNiCr-3 filler was selected to produce the conventional V groove (VG) and narrow V groove (NVG) butt joint. The filler deficient zones in the weldments, such as the filler deficient beach, i.e. unmixed zone (UZ), peninsula, and island, as well as the distinct heat-affected zone (HAZ), were visible near the interface of ERNiCr-3 filler weld and P92 steel due to the distinct differences in the chemical composition, microstructure, and mechanical properties between the filler and P92 base metal (BM). A very narrow partial melted zone (PMZ) and almost negligible UZ and HAZ were noticed at the interface of IN617 and ERNiCr-3 weld metal and it occurred mainly due to the similarity in microstructure and melting point. The austenitic microstructure of ERNiCr-3 filler weld was accompanied by precipitates enriched with Ti and Nb along with the inter-dendritic space. At room temperature, the mechanical properties of both the groove joints were evaluated, and the test results indicated that the welded joint satisfied the standard requirements for AUSC power plants' boiler applications. The tensile test results showed the failure from ERNiCr-3 filler weld with a tensile strength of 627 ± 2 MPa and 636 ± 3 MPa for VG and NVG welded joints, respectively. A poor weld metal impact toughness in comparison to the BMs was attributed to the presence of the brittle Ti(C, N) and Nb(C) particles in the interdendritic space. The impact toughness for the NVG weld joint was measured higher than for the VG weld joint. A significant hardness deviation was measured along the weldments that might be due to heterogeneous microstructure, i.e. UZ, HAZ, delta ferrite, and weld metal. To impart the ductility and temper the martensite in P92 HAZ, post-weld heat treatment (PWHT) was also performed, and a studied their effect on microstructure evolution across the weldments and mechanical properties. Groove design also showed a significant effect on residual stress variation. In comparison to conventional VG joints, the NVG joints exhibited superior mechanical properties and lower residual stress values.
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Paintings
- Krzysztof Wróblewski
The painting as a curtain (...) A contradiction is therefore what constitutes a painting, and ambiguity is its right. As a young artist, I intuitively defined the work of art as a boundary. Over the years that intuition changed into a conviction that the particular form of art which is painting at the same time reveals and hides; it exists at this intersection of functions as a see-through curtain. We don’t know why there are some paintings which we constantly want to have before our eyes and others which we quickly forget. We will never have a complete answer to the question ‘what is a painting?’, because it resists being put into words – it is a part of a cloud, an element of a fog, from which multiplied imagery emerges. We give in to the charm of the curtain, but fictions are nothing bad. Thanks to the ability to create fictions and to believe in them we conquered the world. The reality, however we choose to define it, is woven with pictures. Krzysztof Wróblewski
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Palmiarnia / Gdańsk
- Joanna Kabrońska
Palmiarnia w Parku Oliwskim zyskała nową formę w wyniku rozpoczętego w 2016 roku procesu rewitalizacji, podjętego w celu ochrony zabytkowych budynków, dostosowania ich do obecnych wymagań, a przede wszystkim podkreślenia kulturowych wartości dawnego ogrodu opackiego. Efektem prac rewitalizacyjnych jest dynamiczna, przejrzysta forma, zbudowana z zastosowaniem nowych technologii. Rotunda wraz z odrestaurowaną zabytkową oranżerią wpisuje się w poszukiwania przyszłej - odpowiadającej pojawiającym się wyzwaniom - roli Parku Oliwskiego, dając początek nowej interpretacji tego wyjątkowego miejsca.
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Panopticum 1.0 Curator's choice
- Jan Buczkowski
Wystawa zbiorowa 7 artystów współpracujących z galerią jest kuratorskim wyborem prac w których dominującymi kolorami są czerń i biel. Kuratorem wystawy jest Natalia Bimer
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Paradoxes in the engineering change management process
- Jakub Tryczak
- Anna Lis
- Paweł Ziemiański
Purpose: The main purpose of this paper is to conceptualize and operationalize paradoxes that are significant in the engineering change management (ECM) process. The following research question was stated: What are the paradoxes that influence the ECM process, and how can they be measured? Design/methodology/approach: The study is divided into two parts: conceptualization and operationalization. Conceptualization involved a literature review, which allowed for identifying initial categories of paradoxes that were later verified during in-depth personal interviews with the study participants. The subsequent operationalization involved developing a measurement tool which is a semantic differential scale that allows for assessing the perceived current and desired approach to solving paradoxes affecting ECM. The tool was revised based on in-depth personal interviews with participants of the ECM process. For the study, a manufacturing company which implemented a change management process was selected. Findings: Four general groups of paradoxes previously identified in the paradox theory literature (i.e. learning, belonging, performing, and organizing) were used to develop a list of paradoxes specific to the ECM process. In-depth interviews allowed to obtain data from experienced participants of the process, which was used to verify the preliminary list. The result of this verification was the list of 12 paradoxes that was included in the final measurement tool. Research limitations: Even though the study involved well-informed participants who are experienced in the ECM process, they represented a single company. Additionally, the proposed research tool may require further verification in subsequent studies. Practical implications: The knowledge regarding paradoxes specific to the ECM process and the created tool can be helpful for change administrators, project managers, and other stakeholders. They allow to define the areas of most significant tensions in the ECM process that require attention and effort. Originality/value: This paper's main value pertains to two different domains- cognitive and methodic. The undertaken attempt to include paradoxes and their significance in the analysis of the ECM process broadens the current understanding of process determinants. The proposed research tool, which is based on a well-grounded theoretical approach to paradoxes and adapted to fit the ECM process, can be used in further research.
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Parallel implementation of a Sailing Assistance Application in a Cloud Environment
- Marcin Życzkowski
- Rafał Szłapczyński
- Piotr Orzechowski
- Henryk Krawczyk
Sailboat weather routing is a highly complex problem in terms of both the computational time and memory. The reason for this is a large search resulting in a multitude of possible routes and a variety of user preferences. Analysing all possible routes is only feasible for small sailing regions, low-resolution maps, or sailboat movements on a grid. Therefore, various heuristic approaches are often applied, which can find solutions within an acceptable time, sacrificing their optimality and accuracy. In this study, we propose a different approach based on the parallel implementation of an exact algorithm. Specifically, we present a Sailing Assistance Application (SAA) utilizing a deterministic approach and show how it can be parallelized in a cloud environment to reduce its execution time. The potential of the proposed parallelization method goes beyond the particular presented solution; it can be used to improve the performance of other weather routing tools such as collision avoidance and related applications.
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Peculiarities of measurement uncertainty evaluation at calibrating a ring gauge
- Igor Zakharov
- Olesia Botsiura
- Dimitar Diakov
- Dariusz Świsulski
Example S13 from EA-4/02 M:2013 “Calibration of a ring gauge with a nominal diameter of 90 mm” is analyzed. The report uses the kurtosis method and the law of propagation of expanded uncertainty developed by the authors to the expanded uncertainty evaluation. It is shown that the introduction of a coaxiality correction for the ring gauge and the measuring axis of the comparator leads to the need to estimate its standard measurement uncertainty using the second-order terms of the Taylor series and taking into account the kurtosis of input quantities using the method of partial increments. A good agreement between the results obtained by applying the described procedure and the results obtained by the Monte Carlo method is shown.
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Peer assessment as a method for measuring harmful internet use
- Waldemar W. Koczkodaj
- Alicja Kowalczyk
- Mirosław Mazurek
- Witold Pedrycz
- Grzegorz Redlarski
- Elżbieta Rogalska
- Dominik Strzałka
- Agnieszka Szymańska
- Antoni Wilinski
- Songwen Xue
Harmful Internet use (HIU) describes unintended use of the Internet. It could be both self-harm and harming others. Our research goal is to develop a more accurate method for measuring HIU by this novel peer assessment. As such, it may become, with our call for more research, a paradigm shift supplementing every rating scale or other type of Internet use assessment. In addition to classic statistical analysis, structural equations have been employed. Results indicate that the true positive rate (TPR) is substantially higher than assessed in other studies.
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"Pejzaż malarstwa polskiego"
- Dominika Krechowicz
Pejzaż malarstwa polskiego to szeroka i różnorodna prezentacja twórczości polskich współczesnych artystów, którzy przedstawią swoje najnowsze prace. Ekspozycja obejmie ponad 200 dzieł autorstwa 140 malarzy reprezentujących wszystkie aktualne nurty od realizmu i figuracji po abstrakcyjną sztukę bezprzedmiotową oraz obiekty. Na wystawie Pejzaż malarstwa polskiego obok siebie znajdą się prace uznanych klasyków współczesności, malarzy średniego pokolenia oraz najciekawszych młodych artystów i debiutantów. Malarze, którzy biorą udział w tym projekcie, reprezentują wszystkie najważniejsze w naszym kraju artystyczne uczelnie, ośrodki sztuki oraz kulturalne środowiska. Po prawie dwóch dekadach od pamiętnej wystawy Malarstwo polskie XXI wieku, Zachęta – Narodowa Galeria Sztuki zaprasza do obejrzenia ekspozycji Pejzaż malarstwa polskiego, która ponawia pytanie o rangę i miejsce w kulturze oraz przyszłość tej niezmiennie wiodącej dziedziny sztuk plastycznych. https://zacheta.art.pl/pl/wystawy/pejzaz-malarstwa-polskiego
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Performance assessment of OpenMP constructs and benchmarks using modern compilers and multi-core CPUs
- Bartłomiej Gawrych
- Paweł Czarnul
Considering ongoing developments of both modern CPUs, especially in the context of increasing numbers of cores, cache memory and architectures as well as compilers there is a constant need for benchmarking representative and frequently run workloads. The key metric is speed-up as the computational power of modern CPUs stems mainly from using multiple cores. In this paper, we show and discuss results from running codes such as: batch normalization, convolution, linear function, matrix multiplication, prime number test and wave equation; using compilers such as: GNU gcc, LLVM clang, icx, icc; run on four different 1 or 2-socket systems: 1 x Intel Core i7-5960X, 1 x Intel Core i9-9940X, 2 x Intel Xeon Platinum 8280L, 2 x Intel Xeon Gold 6130. Results can be regarded as suggestions concerning scaling on particular CPUs including recommended thread number configurations.
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Performance Evaluation of Asphalt Binder Modified with Shear Thickening Fluid
- Tanveer Hassan
- Naveed Ahmad
- Diyar Khan
- Mohd Rosli Mohd Hasan
- Akhlaq Aman
- Umar Farooq
This paper aims at using a dilatant or shear thickening fluid (STF) [a non-Newtonian fluid consisting of particles of nano-silica suspended in a liquid medium, i.e., ethylene glycol (EG), which acts as a carrier fluid; proportion 40:60] as additive or modifier of bitumen in order to enhance its viscoelastic properties. A commonly-used performance grading (PG) system, storage stability test, and different conventional and rheological tests were carried out to optimize the dosage of the STF into the bitumen (investigating the influence of 2%, 4%, and 6% of STF on the bitumen) and to define the related properties. The results show that using 4% STF by weight of the binder (an asphalt binder with an 80/100 penetration grade) improves high-temperature viscoelastic properties and bitumen performance grading.
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Performance of cryogenic oxygen production unit with exhaust gas bleed for sewage sludge gasification and different oxygen purities
- Maja Kaszuba
- Paweł Ziółkowski
- Dariusz Mikielewicz
The paper presents a thermodynamic analysis of the integration of a cryogenic air separation unit into a negative CO2 emission gas power plant. The power cycle utilizes sewage sludge as fuel so this system fits into the innovative idea of bioenergy with carbon capture and storage. A cryogenic air separation unit integrated with the power plant was simulated in professional plant engineering and thermodynamic process analysis software. Two cases of the thermodynamic cycle have been studied, namely with the exhaust bleed for fuel treatment and without it. The results of calculations indicate that the net efficiencies of the negative CO2 emission gas power plant reach 27.05% (combustion in 95.0% pure oxygen) and 24.57% (combustion in 99.5% pure oxygen) with the bleed. The efficiencies of the cycle without the bleed are 29.26% and 27.0% for combustion in 95.0% pure oxygen and 99.5% pure oxygen, respectively. For the mentioned cycle, the calculated energy penalty of oxygen production was 0.235 MWh/kgO2 for the lower purity value. However, for higher purity namely 99.5%, the energy penalty of oxygen production for the thermodynamic cycle including the bleed and excluding the bleed was indicated 0.346 and 0.347 MWh/kgO2,respectively.
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Performance tuning of chitosan-based membranes by protonated 2-Pyrrolidone-5-carboxylic acid-sulfolane DES for effective water/ethanol separation by pervaporation
- Roberto Castro-Muñoz
- Łukasz Cichocki
- Maksymilian Plata-Gryl
- Grzegorz Boczkaj
- Francesco Galiano
Today, the applicability of deep eutectic solvents (DES) in various fields, including membrane science and technology, is extensively investigated. In pioneering works, we have implemented different DES as a component of chitosan (CS)-based flat membranes for pervaporation (PV) separation. Herein, we present a new protonated (by sulphuric acid) 2-Pyrrolidone-5-carboxylic acid: sulfolane DES, as a green additive for its chemical blending and thus study its effect in CS structure. The resultant flat CS-based membranes have been characterized and tested for their ability in separating water molecules from ethanolic mixtures (10 wt.% water in ethanol) using PV. Experiments revealed a progressive increase in total permeation along with increase of temperature in the range of 20 to 50°C. Simultaneously, the value of separation factor was reduced. The maximum permeation (approximately 0.44 kg m-2 h -1 ) was observed for the highest experimental temperature, in which water was the main component, while the highest separation factor (approximately 518) was observed for lowest operating temperature. It was confirmed that application of selected DES allowed to improve the permeation rates in comparison with the bare CS membrane. As a perspective, such membranes could be tested for another hydrophilic pervaporation applications for the removal of polar compounds – with high applicability in biorefineries.
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Periodic and chaotic dynamics in a map‐based neuron model
- Frank Llovera Trujillo
- Justyna Signerska-Rynkowska
- Piotr Bartłomiejczyk
Map-based neuron models are an important tool in modeling neural dynamics and sometimes can be considered as an alternative to usually computationally costlier models based on continuous or hybrid dynamical systems. However, due to their discrete nature, rigorous mathematical analysis might be challenging. We study a discrete model of neuronal dynamics introduced by Chialvo in 1995. In particular, we show that its reduced one-dimensional version can be treated as an independent simple model of neural activity where the input and the fixed value of the recovery variable are parameters. This one-dimensional model still displays very rich and varied dynamics. Using the fact that the map whose iterates define voltage dynamics is S-unimodal, we describe in detail both the periodic behavior and the occurrence of different notions of chaos, indicating corresponding regions in parameter space. Our study is also complemented by a bifurcation analysis of the mentioned dynamical model.
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Permeability of sandy soils estimated from particle size distribution and field measurements
- Wioletta Gorczewska-Langner
- Anna Gumuła-Kawęcka
- Beata Jaworska-Szulc
- Rafael Angulo-Jaramillo
- Adam Szymkiewicz
Accurate estimation of soil permeability is crucial in many geotechnical applications. Empirical and theoretical equations based on soil particle size distribution (PSD) offer a fast and cheap way for preliminary estimation of permeability in granular soils, however the results obtained from various formulas available in the literature often show significant discrepancies. While several comparative studies on this topic have been published, no definite conclusions can be drawn on the performance of the predictive equations in comparison with in-situ permeability measurements. Many formulas require porosity or void ratio as input parameter, which is difficult to obtain for granular soil in-situ. In this study we applied 30 predictive equations to estimate permeability of sandy soil in an outwash plain deposit. The equations were divided into 5 groups, based on their structure and the required input parameters. Empirical formulas were used to estimate the expected in-situ porosity range. The obtained permeability values were compared to the results of in-situ permeameter measurements and pumping tests. Significant differences in the results and in their sensitivity to porosity were found between the 5 groups of methods. In general, simple equations which do not include porosity were in better agreement with measurements than the other groups.
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Peroxymonosulfate-assisted photocatalytic degradation of artificial sweeteners in water
- Jakub Smoliński
- Agnieszka Fiszka Borzyszkowska
- Paweł Kubica
- Anna Zielińska-Jurek
In the present study, peroxymonosulfate (PMS) activation was proposed for efficient photocatalytic degradation of aspartame, acesulfame, saccharin, and cyclamate - artificial sweeteners frequently present in wastewaters and surface waters worldwide. The TiO2 nanosheets with exposed {0 0 1} facets were synthesised using the fluorine-free lyophilisation technique as a green concept for the synthesis and used for the photodegradation of selected sweeteners not susceptible to biodegradation. The synergetic effect of photocatalysis with the sulfate radical-based process was for the first time investigated. It was found that the studied artificial sweeteners were practically not susceptible to photolysis within 60 minutes of irradiation. In the presence of 2D titanium (IV) oxide, the artificial sweeteners were degraded entirely in less than 30 min, whereas the addition of peroxymonosulfate resulted in complete degradation after 10 – 15 minutes of the process.
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Persistences: analysis of the image of Gdańsk and its cultural identity through survey processes and digital architectural representation
- Sandro Parrinello
- Justyna Borucka
- Jakub Szczepański
- Francesca Picchio
The aim of the research was to analyse the historical legacy/heritage of the city of Gdańsk in order to characterise the narrative tools which can be used to promote the cultural identity of the urban landscape. The main focus was on the city's defence system - a cultural route that is spatially limited to a relatively small area, but temporally spanning almost a millennium. The fortifications demarcate a spatial boundary, limiting the urban layout, which has remained distinguishable over the centuries, however changing its image. The research activities have been carried out by a multidisciplinary group of scholars participating in the H2020 PROMETHEUS European project aimed at developing innovative methodologies for digitising architecture with the integration of multidisciplinary data and information models, leading to specialised figures capable of operating on heritage built assets. The image of the city and the urban landscape is transforming in an attempt to strengthen its historical identity. In each century, new architectural and formal models are introduced, which become integrated with the structural characteristics of the urban layout, altering the urban space. Today, in the digital age, it is becoming strategic not only to convert architecture and its models, but also to make the urban image more explicit, trying to translate the invariants of the landscape into the 3D digital databases.
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Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data
- Krystian Zieliński
- Sebastian Pukszta
- Małgorzata Mickiewicz
- Marta Kotlarz
- Piotr Wygocki
- Marcin Zieleń
- Dominika Drzewiecka
- Damian Drzyzga
- Anna Kloska
- Joanna Jakóbkiewicz-Banecka
Controlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched to groups of various MII oocyte counts using ranking, correspondence analysis, and self-organizing map methods. The gradient boosting machine technique was used to train models on a clinical dataset of 8,574 or a clinical-genetic dataset of 516 ovarian stimulations. The clinical-genetic model predicted the number of MII oocytes better than that based on clinical data. Anti-Müllerian hormone level and antral follicle count were the two most important predictors while a genetic feature consisting of sequence variants in the GDF9, LHCGR, FSHB, ESR1, and ESR2 genes was the third. The combined contribution of genetic features important for the prediction was over one-third of that revealed for anti-Müllerian hormone. Predictions of our clinical-genetic model accurately matched individuals’ actual outcomes preventing over- or underestimation. The genetic data upgrades the personalized prediction of ovarian stimulation outcomes, thus improving the in vitro fertilization procedure.
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‘Personas for lighting’. Three methods to develop personas for the indoor lighting environment
- Natalia Sokół
- Justyna Martyniuk-Pęczek
- Barbara Matusiak
- Claudia Naves David Amorim
- Marta Waczynska
- Julia Kurek
- Natalia Giraldo Vasquez
- Sergio Sibilio
- Julia Kanno
- Michelangelo Scorpio
- Marzieh Nazari
- Yasuko Koga
The objective of this research is to describe and compare three different methods of generating ‘persona for lighting’ to envision users’ behaviour within the lighting environment. ‘Personas’ are used to represent typical users, highlighting their needs, perspectives, and expectations to aid user-centric design approaches. The researchers looked for the most useful method of shaping ‘personas for lighting’ to learn about users’ satisfaction with the various lighting conditions to identify their needs. Method one of lighting persona development, was based on interviews with 87 users of five buildings of four different types: an office, a primary school, two university buildings, and a factory. The lighting conditions were observed and measured in all the buildings. As a result, 22 personas for lighting were created. In method two personas were generated based on pre-interviews, workshops on lighting and post-interviews with ten users along with the onsite lighting measurements. Later, due to the Covid-19 pandemic’s lockdowns, an online survey on the visual lighting environment in home offices was carried out among 694 students and professionals from seven countries to create two more personas for lighting (method three). All 26 ‘personas for lighting’ were generated in relation to observed lighting conditions, based on the satisfaction, preferences and needs of the users working within variously lit indoor environments. All the tested methods can be used for nearly any type of building and room, but the resulting personas are different due to the specific limitations of the methods. The created personas may help to identify future users’ lighting preferences, needs and requirements and assist designers. However, to fully understand their impact on the lighting research practice they should be tested in real projects
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Phage Therapy—Challenges, Opportunities and Future Prospects
- Beata Zalewska-Piątek
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly. Phages that selectively infect and kill bacteria are often the only life-saving therapeutic option. Full legalization of this treatment method could help solve the problem of multidrug-resistant infectious diseases on a global scale. The aim of this review is to present the prospects for the development of phage therapy, the ethical and legal aspects of this form of treatment given the current situation of such therapy, and the benefits of using phage products in persons for whom available therapeutic options have been exhausted or do not exist at all. In addition, the challenges faced by this form of therapy in the fight against bacterial infections are also described. More clinical studies are needed to expand knowledge about phages, their dosage, and a standardized delivery system. These activities are necessary to ensure that phage-based therapy does not take the form of an experiment but is a standard medical treatment. Bacterial viruses will probably not become a miracle cure—a panacea for infections—but they have a chance to find an important place in medicine.
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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
- Karolina Kaźmierczak-Siedlecka
- Nikola Bulman
- Paweł Ulasiński
- Bartosz Kamil Sobocki
- Karol Polom
- Luigi Marano
- Leszek Kalinowski
- Karolina Skonieczna-Żydecka
Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively gathered scientific evidence on the interplay between anticancer therapies and gut microbes. We also underlined how such interactions might impact the host response to a given therapy. We discuss the possibility of modulating the gut microbiota to increase the effectiveness/decrease the incidence of adverse events during tumor therapy. The anticipation of the future brings new evidence that gut microbiota is a target of interest to increase the efficacy of therapy.
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Philosophy of Symbolic Forms and a Mystery of “Appearing Itself ”. Cassirer in the Context of Phenomenology
- Przemysław Parszutowicz
in the publications concerning Cassirer, whose number has been increasing for about a dozen years, more and more space is devoted to the genesis of his philosophy, and more attention is paid to its linkage to Neo-Kantian Marburg school. Also, in addition to Kantian, Hegelian and Goethean heritage in Cassirer’s philosophy is indicated, while its discovered philosophical foundations make it possible to regard the author of The Philosophy of Symbolic Forms not only as a historian and theoretician of philosophy and culture, but also as the creator of an original philosophical system, where motifs referring to metaphysics can also be found, and which is founded on phenomenology understood in a specific way.
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Phosphinoborenium cations stabilized by N-heterocyclic carbenes: synthesis, structure, and reactivity
- Kinga Kaniewska-Laskowska
- Anna Ordyszewska
- Tomasz Wojnowski
- Hanna Halenka
- Marcin Czapla
- Jarosław Chojnacki
- Rafał Grubba
Phosphinoborenium cations stabilized by N-heterocyclic carbenes (NHCs) were synthesized via the reaction of bromo(phosphino)boranes with NHCs. Their structures were investigated by heteronuclear magnetic resonance spectroscopy, X-ray diffraction, and density functional theory calculations. They possess a planar trigonal boron center directly bonded with the pyramidal phosphanyl group (PR2) and can be treated as cationic phosphinoboranes. The reactivity of the selected NHC-phosphinoborenium cation was tested toward AuCl·SMe2 and Ph2PCl. In both reactions, the titled compound acted as a phosphido group donor under heterolytic cleavage of the P–B bond. Control experiments with parent phosphinoborane emphasized differences between the reactivity of low-coordinate neutral and cationic species with P–B functionality.
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Photocatalytic decolourization of Rhodamine-B dye by visible light active ZIF-8/BiFeO3 composite
- Bhaskar Bethi
- Gidla Bhanu Radhika
- Le Minh Thang
- Shirish H. Sonawane
- Grzegorz Boczkaj
In this work, preparation of ZIF-8 supported BiFeO3 photocatalyst by ultrasound cavitation technique was reported. The synthesized materials were characterized using solid UV absorption spectroscopy, Raman Spectroscopy, and SEM. The catalytic function of synthesized photocatalyst under ultraviolet and visible light was examined for the decolourization of Rhodamine-B (Rh-B) dye. To understand the action of the photocatalyst on Rh-B decolorization, the influence of different operating parameters such as wt% of ZIF-8 in composite, catalyst dosage, initial dye concentration, initial solution pH, and source of light was examined. The obtained results show that 40.7 wt% of ZIF-8/BiFeO3 composite exhibited the highest possible photocatalytic behaviour against decolorization of Rh-B dye. The acidic pH of the solution had shown greater effectiveness in removing Rh-B dye. The tests and study demonstrate that the hybrid ZIF-8/BiFeO3 has a stronger photocatalytic activity for decolorization of the Rh-B dye relative to the ZIF-8 MOF and BiFeO3. The synthesized ZIF-8/BiFeO3 demonstrated outstanding photocatalytic behaviour in the presence of ultraviolet and visible light towards the removal of Rh-B dye from the aqueous media.
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Photocatalytic degradation and pollutant-oriented structure-activity analysis of carbamazepine, ibuprofen and acetaminophen over faceted TiO2
- Szymon Dudziak
- Agnieszka Fiszka Borzyszkowska
- Anna Zielińska-Jurek
Photocatalytic degradation of carbamazepine, ibuprofen, acetaminophen and phenol was studied in the presence of anatase photocatalyst, exposing three different crystal facets in the majority of {0 0 1}, {1 0 0} or {1 0 1}. It was found that octahedral anatase particles exposing {1 0 1} facets allow to achieve the best degradation and mineralization of all persistent organic pollutants. This confirms that the previous findings, showing high {1 0 1} activity, are not limited to phenol and could be generalized for other water pollutants. Based on the obtained results, a correlation model including exposed TiO2 crystal facet and chemical hardness of the pollutant was developed to predict the degradation rate of pollutants with a possibly diverse electronic structure. The structureactivity analyses, based on the reactivity predictors obtained from the DFT calculations for all tested compounds, have shown that pollutants with higher chemical hardness react faster with the photocatalyst. Alternatively, a similar effect was observed for the higher HOMO-LUMO energy gap of the compound. This relation indicates that for compounds with a low energy position of LUMO orbital, e.g., carbamazepine, process efficiency is not strictly dependent on the stability of h+ generated organic radical, which is often pointed out as an initial reactive form. Based on these results, a correlation model was developed for the first time to quantitatively describe the effect of the facet-pollutant interactions based on their independent electronic properties. Finally, this was followed by the detailed degradation study of the pharmaceuticals mixture, showing the impact of the total concentration and role of active species on the degradation efficiency over facet-engineered TiO2 photocatalysts.
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Photocatalytic hydrogen evolution from glycerol-water mixture under visible light over zinc indium sulfide (ZnIn2S4) nanosheets grown on bismuth oxychloride (BiOCl) microplates
- Onur Cavdar
- Mateusz Baluk
- Anna Malankowska
- Andrzej Zak
- Wojciech Lisowski
- Tomasz Klimczuk
- Adriana Zaleska-Medynska
- Mateusz Adam Baluk
ZnIn2S4 (ZIS) is one of the widely studied photocatalyst for photocatalytic hydrogen evolution applications due to its prominent visible light response and strong reduction ability. However, its photocatalytic glycerol reforming performance for hydrogen evolution has never been reported. Herein, the visible light driven BiOCl@ZnIn2S4 (BiOCl@ZIS) composite was synthesized by growth of ZIS nanosheets on a template-like hydrothermally pre-prepared wide-band-gap BiOCl microplates using simple oil-bath method to be used for the first time for photocatalytic glycerol reforming for photocatalytic hydrogen evolution (PHE) under visible light irradiation (k > 420 nm). The optimum amount of BiOCl microplates in the composite was found 4 wt% (4% BiOCl@ZIS) in the presence of in-situ 1 wt% Pt deposition. Then, the in-situ Pt photodeposition optimization studies over 4% BiOCl@ZIS composite showed the highest PHE rate of 674 lmol g-1h1 with the ultra-low platinum amount (0.0625 wt%). The possible mechanisms behind this improvement can be ascribed to the formation of Bi2S3 low-band-gap semiconductor during BiOCl@ZIS composite synthesis resulting in Z-scheme charge transfer mechanism between ZIS and Bi2S3 upon visible light irradiation. This work expresses not only the photocatalytic glycerol reforming over ZIS photocatalyst but also a solid proof of the contribution of wide-band-gap BiOCl photocatalysts to enhancement of ZIS PHE performance under visible light.
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Photonic sensor to detect rapid changes in CRP levels
- Małgorzata Szczerska
- Monika Kosowska
- Roman Viter
- Paweł Wityk
One of the most important biomarkers used to determine inflammation is C-reactive protein (CRP). Its level, when it is within the range that does not define inflammation, informs about the risk of cardiovascular events. If the norm is exceeded and inflammation is detected in the body, CRP level can increase 1000 times within a few hours. The type of infection can also be determined based on the level of elevated CRP. All this makes CRP a very important element of diagnostics. A sensor based on low coherence interference is presented. Preliminary studies have shown that its sensitivity is 5.65 μg/L and the measurement time is short, <10 min. The entire system is built of commercially available components, which allow production cost minimalization. In addition, the user-friendly operation allows it to be operated by unqualified people. Due to these features, our solution is a promising alternative to commercially used enzyme-linked immunosorbent assay, which needs trained personnel to perform time-consuming measurement procedures.
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Photos and rendered images of LEGO bricks
- Tomasz Boiński
The paper describes a collection of datasets containing both LEGO brick renders and real photos. The datasets contain around 155,000 photos and nearly 1,500,000 renders. The renders aim to simulate real-life photos of LEGO bricks allowing faster creation of extensive datasets. The datasets are publicly available via the Gdansk University of Technology “Most Wiedzy” institutional repository. The source files of all tools used during the creation of the dataset were made publicly available via GitHub repositories. The images, both photos and the renders were annotated with the unique brick ID and category from the official LEGO catalog. The proposed datasets are stored in easy-to-read formats and are labeled via directory structure allowing easy manipulation and conversion of metadata to other formats.
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
- Joanna Pilch
- Agnieszka Potęga
- Agata Kowalczyk
- Artur Kasprzak
- Patrycja Kowalik
- Piotr Bujak
- Ewa Paluszkiewicz
- Ewa Augustin
- Anna M. Nowicka
Selective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the inclusion complex with β-cyclodextrin molecule, due to the presence of a planar fragment in its structure. The stability of such a complex is pH-dependent. The drug release profile at different pH values and the mechanism of C-2028 release from QDs-β-CD-FA nanoconjugates were investigated. Next, the intracellular fate of compounds and their influence on lysosomal content in the cells were also studied. Confocal Laser Scanning Microscopy studies proved that all investigated compounds were delivered to acidic organelles, the pH of which promoted an increased release of C-2028 from its nanoconjugates. Since the pH in normal cells is higher than in cancer cells, the release of C-2028 from its nanoconjugates is decreased in these cells. Additionally, we obtained the concentration profiles of C-2028 in the selected cells treated with unbound C-2028 or nanoconjugate by the HPLC analysis.
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Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts
- Marika Mróz
- Barbara Kusznierewicz
This study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts. An untargeted UPLC/MS‑based metabolomics was performed to discover metabolites profile variation between the extracts. In the analyzed samples, 2704 features had been detected, of which 95 were tentatively identified. The concentrations of the important metabolites, namely, caffeic acid, carnosic acid, carnosol, rosmarinic acid, salvianolic acid B and scutellarin, were determined, using UPLC-PDA methods. Rosmarinic acid was the dominant metabolite and antioxidant in all tested extracts, except the aqueous extract, in which scutellarin was the most abundant compound. The extracts and standards were examined for antioxidant activity and xanthine oxidase (XO) inhibitory activity. The most diverse in terms of chemical composition and rich in antioxidant compounds was 70% ethanolic extract and the strongest antioxidant was caffeic acid. All analyzed extracts showed the ability to inhibit XO activity, but the highest value was recorded for 30% ethanolic extract. Among tested standards, the most potent XO inhibitor was caffeic acid. The results suggest that the leaves of Greek sage are a source of natural XO inhibitors and may be an alternative to drugs produced by chemical synthesis.
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Pin-on-Substrate Gap Waveguide: An Extremely Low-Cost Realization of High-Performance Gap Waveguide Components
- Ali Karami Horestani
- Michał Mrozowski
Considering the limitations of currently available technologies for the realization of microwave components and antennas, a trade-off between different factors including the efficiency and fabrication cost is required. The main objective of this letter is to propose a novel method for the realization of gap waveguides (GWGs) that take advantage of conventional PCB fabrication technology, thus are low cost and light weight. Moreover, by avoiding dielectric loss and minimizing conductive loss, the proposed GWGs benefit from a very low loss. To highlight potential applications, a high-performance slot-array antenna based on the proposed GWG is presented.
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Planning Around Polarisation: Components of Finding Common Ground Based on Regeneration Projects in London and Gdańsk
- Piotr Lorens
- Agnieszka Zimnicka
Various forms of public participation in urban design and planning—as presented and discussed in literature—have recently been challenged by the needs and expectations of different stakeholders, including those coming from the private sector. This comes with a redefinition of the public good and the roles and responsibilities of municipal authorities in post‐liberal times. As a result, contemporary participatory processes need to evolve to accommodate not only the wishes and ideas of the local communities, but also those of institutional stakeholders including investors, developers and land owners. This is also accompanied by the demands, expressed by all partners in this process, associated with having a much stronger influence on the final shape of the development policies and planning regulations. The gradual democratisation of spatial planning results in more engagement of stakeholders in the process. The article focuses on the co‐design method as a way to bridge the polarisation of interests and find a consensus. The article focuses on identifying co‐design components lead‐ ing to the successful bridging of divisions and the realisation of large‐scale regeneration initiatives that could be replicated. The authors have selected examples of large‐scale regeneration areas in London and Gdańsk for a qualitative assessment, given the growing polarisation in both Polish and British societies. The discussion will focus on aspects of inclusivity, partnership working in co‐design and political risks associated with co‐design
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Platelet RNA Sequencing Data Through the Lens of Machine Learning
- Sebastian Cygert
- Krzysztof Pastuszak
- Franciszek Górski
- Michał Sieczczyński
- Piotr Juszczyk
- Antoni Rutkowski
- Sebastian Lewalski
- Robert Różański
- Maksym Albin Jopek
- Jacek Jassem
- Andrzej Czyżewski
- Thomas Wurdinger
- Myron G Best
- Anna Żaczek
- Anna Supernat
Liquid biopsies offer minimally invasive diagnosis and monitoring of cancer disease. This biosource is often analyzed using sequencing, which generates highly complex data that can be used using machine learning tools. Nevertheless, validating the clinical applications of such methods is challenging. It requires: (a) using data from many patients; (b) verifying potential bias concerning sample collection; and (c) adding interpretability to the model. In this work, we have used RNA sequencing data of tumor-educated platelets (TEPs) and performed a binary classification (cancer vs. no-cancer). First, we compiled a large-scale dataset with more than a thousand donors. Further, we used different convolutional neural networks (CNNs) and boosting methods to evaluate the classifier performance. We have obtained an impressive result of 0.96 area under the curve. We then identified different clusters of splice variants using expert knowledge from the Kyoto Encyclopedia of Genes and Genomes (KEGG). Employing boosting algorithms, we identified the features with the highest predictive power. Finally, we tested the robustness of the models using test data from novel hospitals. Notably, we did not observe any decrease in model performance. Our work proves the great potential of using TEP data for cancer patient classification and opens the avenue for profound cancer diagnostics.
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Pluralist View on Inequality from Luxemburg Income Study (LIS)
- Daniele Checchi
- Piotr Paradowski
The authors start by reviewing the history of the Luxembourg Income Study (LIS), originating from an interdisciplinary project involving economists, sociologists, and political scientists, centered on the cross-country perspective in inequality analysis. They then conduct a meta-analysis of the papers produced by scholars who have taken advantage of the data availability, showing how the theme of income/wealth inequality has been differently addressed in the research conducted thank to free availability of LIS data. The analysis is based on 268 LIS/LWS working papers produced since 2013 by LIS data users. Inequality analysis, an elusive and multidimensional concept, cannot become prerogative of a specific discipline or school of thought, favoring a pluralist approach to the topic. As a consequence, we present how four academic communities (economists, sociologists, social policy, and political scientists) adopt different methodological perspectives in terms of unit of analysis (the individual, the household, or the community), heterogeneity (by gender, age, race, education), outcomes (income, wealth, consumption, education, employment, and work hours, fertility), institutional framework (household, local labor markets, nations) and methodological approach (poverty, inequality, income shares).
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Pływające wyspy hydrofitowe jako rozwiązanie problemów eutrofizacji wód – koncepcja metody, zastosowanie i wybrane zagadnienia projektowe
- Nicole Nawrot
- Natalia Janowicz
- Ewa Wojciechowska
Pływające wyspy hydrofitowe są coraz częściej spotykanym elementem krajobrazu – szczególnie na otwartych akwenach miejskich. Posiadają walory estetyczne, są rozwiązaniami opartymi na naturze, poprawiają mikroklimat, a przede wszystkim pełnią funkcję oczyszczającą. Do tej pory jednak nie udało się precyzyjnie sklasyfikować rozwiązań pływających wysp hydrofitowych (z ang. floating treatment islands) w nomenklaturze polskiej. Brakuje również specyficznych wytycznych do ich projektowania. W niniejszym artykule podjęto się wyjaśnienia idei metody, klasyfikacji systemu pływających wysp hydrofitowych, omówiono podstawowe mechanizmy usuwania zanieczyszczeń oraz wybrane zagadnienia projektowe. Praca powstała w wyniku realizacji projektu Preludium 18 [2019/35/N/ST8/01134].
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POLAND’S ENERGY DEPENDENCE AT THE TURN OF THE 21ST CENTURY
- Krystyna Gomółka
- Piotr Kasprzak
The following article is an attempt to assess Poland's energy independence in the years 1993-2020. The main aim of the paper is to present Poland's dependence on raw materials from foreign partners - in the field of imports of electricity, natural gas, crude oil, non-renewable energy resources, i.e., hard coal and lignite, and the country's dynamics in the amount of imports. In addition, the aim of the work is to answer research questions pertaining to the level of Poland's energy dependence on foreign sources, countries from which Poland imported energy or energy resources, the structure of imports, as well as the country's energy balance in the period under study. The research methods used in the paper include a descriptive research method, an analysis of Eurostat data as well as the literature review in the field of the subject study. The main results posit that, in the analyzed period, Poland was highly dependent on foreign energy sources, especially in the field of gas and crude oil. What is more, between 1993- 2020, a growing diversification of energy resources sources was noted.